Showcasing research from Professor Chun-yang Zhang’s As featured in: laboratory, College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan, China. Controllable fabrication of bio-bar codes for dendritically ampliﬁ ed sensing of human T-lymphotropic viruses We demonstrate for the ﬁ rst time the controllable fabrication of bio-bar codes for dendritically ampliﬁ ed sensing of low-abundant HTLV-II DNA by the integration of terminal deoxynucleotidyl transferase-catalyzed template-free polymerization extension with bio-bar-code ampliﬁ cation. This method exhibits ultrahigh sensitivity with a limit of detection of as low as 0.50 aM and a large dynamic range of 9 orders of magnitude from 1 aM to 1 nM, and it can be applied for the discrimination of a single-base See Chun-yang Zhang et al., Chem. Sci., 2018, 9, 4942. mismatch and the measurement of HTLV-II DNA in both human serum and human T-lymphocytic leukemia cells. rsc.li/chemical-science Registered charity number: 207890
Chemical Science – Royal Society of Chemistry
Published: Jun 6, 2018
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