DNA interactions of non-chelating tinidazole-based coordination compounds and their structural, redox and cytotoxic propertiesElectronic supplementary information (ESI) available: X-ray crystallographic data, electrochemical data, copper(ii) solution electronic spectra, and in vitro cytotoxicity data. CCDC 18208331820836. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c8dt00716k

DNA interactions of non-chelating tinidazole-based coordination compounds and their structural,... Novel tinidazole (tnz) coordination compounds of different geometries were synthesised, whose respective solid-state packing appears to be driven by inter- and intramolecular lone pair interactions. The copper(ii) compounds exhibit interesting redox properties originating from both the tnz and the metal ions. These complexes interact with DNA through two distinct ways, namely via electrostatic interactions or/and groove binding, and they can mediate the generation of ROS that damage the biomolecule. Cytotoxic studies revealed an interesting activity of the dinuclear compound [Cu(tnz)2(-Cl)Cl]27, which is further more efficient towards cancer cells, compared with normal cells. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Dalton Transactions Royal Society of Chemistry

DNA interactions of non-chelating tinidazole-based coordination compounds and their structural, redox and cytotoxic propertiesElectronic supplementary information (ESI) available: X-ray crystallographic data, electrochemical data, copper(ii) solution electronic spectra, and in vitro cytotoxicity data. CCDC 18208331820836. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c8dt00716k

Loading next page...
 
/lp/rsc/dna-interactions-of-non-chelating-tinidazole-based-coordination-ZF3C2l4Dmy
Publisher
The Royal Society of Chemistry
Copyright
This journal is © The Royal Society of Chemistry
ISSN
1477-9226
eISSN
1477-9234
D.O.I.
10.1039/c8dt00716k
Publisher site
See Article on Publisher Site

Abstract

Novel tinidazole (tnz) coordination compounds of different geometries were synthesised, whose respective solid-state packing appears to be driven by inter- and intramolecular lone pair interactions. The copper(ii) compounds exhibit interesting redox properties originating from both the tnz and the metal ions. These complexes interact with DNA through two distinct ways, namely via electrostatic interactions or/and groove binding, and they can mediate the generation of ROS that damage the biomolecule. Cytotoxic studies revealed an interesting activity of the dinuclear compound [Cu(tnz)2(-Cl)Cl]27, which is further more efficient towards cancer cells, compared with normal cells.

Journal

Dalton TransactionsRoyal Society of Chemistry

Published: May 23, 2018

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off