Synthesis of TiO 2 nanotubes with ZnO nanoparticles to achieve antibacterial properties and stem cell compatibility

Synthesis of TiO 2 nanotubes with ZnO nanoparticles to achieve antibacterial properties and stem... To endow titanium (Ti) with antibacterial properties, different concentrations of zinc oxide (ZnO) nanoparticles were decorated on anodized titanium dioxide (TiO 2 ) nanotubes by a simple hydrothermal treatment method. The particle sizes of ZnO, which were evenly distributed and tightly adherent to the walls of the Ti nanotubes, ranged from 20–50 nm. Results from this study showed that Zn was released from the TiO 2 nanotubes in a constant, slow, and biologically inspired manner. Importantly, the results showed that the ZnO decorated TiO 2 nanotubular samples inhibited Streptococcus mutants and Porphyromonas gingivalis growth compared to control unmodified Ti samples. Specifically, S. mutants and P. gingivalis growth were both reduced 45–85% on the ZnO decorated Ti samples compared to Ti controls after 7 days of culture. When examining the mechanism of action, it has been further found for the first time that the ZnO decorated Ti samples inhibited the expression of Streptococcus mutans bacterial adhesion genes. Lastly, the results showed that the same samples which decreased bacterial growth the most (0.015 M precursor Zn(NO 3 ) 2 samples) did not inhibit mesenchymal stem cell growth compared to Ti controls for up to 7 days. In summary, results from this study showed that compared to plain TiO 2 nanotubes, TiO 2 decorated with 0.015 M ZnO provided unprecedented antibacterial properties while maintaining the stem cell proliferation capacity necessary for enhancing the use of Ti in numerous medical applications, particularly in dentistry. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nanoscale Royal Society of Chemistry

Synthesis of TiO 2 nanotubes with ZnO nanoparticles to achieve antibacterial properties and stem cell compatibility

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Publisher
The Royal Society of Chemistry
Copyright
This journal is © the Partner Organisations 2014
ISSN
2040-3364
eISSN
2040-3372
D.O.I.
10.1039/c4nr01531b
Publisher site
See Article on Publisher Site

Abstract

To endow titanium (Ti) with antibacterial properties, different concentrations of zinc oxide (ZnO) nanoparticles were decorated on anodized titanium dioxide (TiO 2 ) nanotubes by a simple hydrothermal treatment method. The particle sizes of ZnO, which were evenly distributed and tightly adherent to the walls of the Ti nanotubes, ranged from 20–50 nm. Results from this study showed that Zn was released from the TiO 2 nanotubes in a constant, slow, and biologically inspired manner. Importantly, the results showed that the ZnO decorated TiO 2 nanotubular samples inhibited Streptococcus mutants and Porphyromonas gingivalis growth compared to control unmodified Ti samples. Specifically, S. mutants and P. gingivalis growth were both reduced 45–85% on the ZnO decorated Ti samples compared to Ti controls after 7 days of culture. When examining the mechanism of action, it has been further found for the first time that the ZnO decorated Ti samples inhibited the expression of Streptococcus mutans bacterial adhesion genes. Lastly, the results showed that the same samples which decreased bacterial growth the most (0.015 M precursor Zn(NO 3 ) 2 samples) did not inhibit mesenchymal stem cell growth compared to Ti controls for up to 7 days. In summary, results from this study showed that compared to plain TiO 2 nanotubes, TiO 2 decorated with 0.015 M ZnO provided unprecedented antibacterial properties while maintaining the stem cell proliferation capacity necessary for enhancing the use of Ti in numerous medical applications, particularly in dentistry.

Journal

NanoscaleRoyal Society of Chemistry

Published: May 15, 2014

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