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Ion-channel engineering

Ion-channel engineering The channel-mediated transport of ions through a membrane is of great importance in biological systems and holds a considerable potential for sensing applications. Ion-channel engineering follows two approaches. The first is the engineering of biological channels with the goal to control existing functionality. Currently, this area benefits from progress in structural information of ion channels, new methods in protein engineering (protein semi-synthesis), and the inclusion of chemical synthesis to obtain hybrid ion channels. The second approach in ion channel engineering is the de novo design. Here, progress emerges from self-assembly concepts to prepare β-barrel and π-barrel pores. This review focuses on contributions published in the year 2007 with inclusion of selected work of the time span 2005–2006. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Reports Section "C" (Physical Chemistry) Royal Society of Chemistry

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Publisher
Royal Society of Chemistry
Copyright
This journal is © The Royal Society of Chemistry
ISSN
0260-1826
eISSN
1460-4787
DOI
10.1039/b703980h
Publisher site
See Article on Publisher Site

Abstract

The channel-mediated transport of ions through a membrane is of great importance in biological systems and holds a considerable potential for sensing applications. Ion-channel engineering follows two approaches. The first is the engineering of biological channels with the goal to control existing functionality. Currently, this area benefits from progress in structural information of ion channels, new methods in protein engineering (protein semi-synthesis), and the inclusion of chemical synthesis to obtain hybrid ion channels. The second approach in ion channel engineering is the de novo design. Here, progress emerges from self-assembly concepts to prepare β-barrel and π-barrel pores. This review focuses on contributions published in the year 2007 with inclusion of selected work of the time span 2005–2006.

Journal

Annual Reports Section "C" (Physical Chemistry)Royal Society of Chemistry

Published: Mar 7, 2008

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