Effective loading of cisplatin into a nanoscale UiO-66 metalorganic framework with preformed defects

Effective loading of cisplatin into a nanoscale UiO-66 metalorganic framework with preformed defects Defects within the nanoscale UiO-66 metalorganic framework (MOF) are created to lock a hybrid phosphonoacetate ligand through ZrOP linkages, leaving the carboxyl group free to anchor cisplatin prodrug cis, cis, trans-[Pt(NH3)2Cl2(OH)2]. A drug loading of 256.5 mg g1 (25.7 wt% based on cisplatin) was achieved with a Zr6:Pt:P ratio of 1.5:1:1, which surpasses defect-free UiO-66 and several other MOF carriers. This framework exhibited a burst release of its payload in PBS solution in the first 2 h, releasing 71% of the drug, including a 50% payload release in less than 1 h. This work demonstrates that MOF defects can be intentionally engineered to achieve a high drug loading, and serves as an alternative to drug encapsulation using the pore void and through the association of the functionalized ligand. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Dalton Transactions Royal Society of Chemistry

Effective loading of cisplatin into a nanoscale UiO-66 metalorganic framework with preformed defects

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Publisher
Royal Society of Chemistry
Copyright
This journal is © The Royal Society of Chemistry
ISSN
1477-9226
eISSN
1477-9234
D.O.I.
10.1039/c9dt00719a
Publisher site
See Article on Publisher Site

Abstract

Defects within the nanoscale UiO-66 metalorganic framework (MOF) are created to lock a hybrid phosphonoacetate ligand through ZrOP linkages, leaving the carboxyl group free to anchor cisplatin prodrug cis, cis, trans-[Pt(NH3)2Cl2(OH)2]. A drug loading of 256.5 mg g1 (25.7 wt% based on cisplatin) was achieved with a Zr6:Pt:P ratio of 1.5:1:1, which surpasses defect-free UiO-66 and several other MOF carriers. This framework exhibited a burst release of its payload in PBS solution in the first 2 h, releasing 71% of the drug, including a 50% payload release in less than 1 h. This work demonstrates that MOF defects can be intentionally engineered to achieve a high drug loading, and serves as an alternative to drug encapsulation using the pore void and through the association of the functionalized ligand.

Journal

Dalton TransactionsRoyal Society of Chemistry

Published: Apr 2, 2019

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