Access the full text.
Sign up today, get DeepDyve free for 14 days.
Luciana Verde, Guiomar Lopes, S.S. Ihara, Neide Jurkiewicz, A. Jurkiewicz (2014)
Acute treatment with alcohol affects calcium signaling and contraction associated with apoptosis in vas deferens of periadolescent rats.European journal of pharmacology, 735
A. Llorens, E. Lloret, P. Picouet, R. Trbojevich, Avelina Fernández (2012)
Metallic-based micro and nanocomposites in food contact materials and active food packagingTrends in Food Science and Technology, 24
Shoshi Keynan, B. Kanner (1988)
gamma-Aminobutyric acid transport in reconstituted preparations from rat brain: coupled sodium and chloride fluxes.Biochemistry, 27 1
T. Duncan (2011)
The communication challenges presented by nanofoods.Nature nanotechnology, 6 11
J. Mckim (2014)
Food additive carrageenan: Part I: A critical review of carrageenan in vitro studies, potential pitfalls, and implications for human health and safetyCritical Reviews in Toxicology, 44
Claudia Andreini, L. Banci, I. Bertini, A. Rosato (2006)
Counting the zinc-proteins encoded in the human genome.Journal of proteome research, 5 1
S. Gratton, P. Ropp, P. Pohlhaus, J. Luft, V. Madden, M. Napier, J. Desimone (2008)
The effect of particle design on cellular internalization pathwaysProceedings of the National Academy of Sciences, 105
F. Wei, C. Qu, T. Song, G. Ding, Z. Fan, Dayong Liu, Yi Liu, Chunmei Zhang, S. Shi, Songlin Wang (2012)
Vitamin C treatment promotes mesenchymal stem cell sheet formation and tissue regeneration by elevating telomerase activityJournal of Cellular Physiology, 227
K. Kasemets, A. Ivask, H. Dubourguier, A. Kahru (2009)
Toxicity of nanoparticles of ZnO, CuO and TiO2 to yeast Saccharomyces cerevisiae.Toxicology in vitro : an international journal published in association with BIBRA, 23 6
B. Chithrani, W. Chan (2007)
Elucidating the mechanism of cellular uptake and removal of protein-coated gold nanoparticles of different sizes and shapes.Nano letters, 7 6
Xin-xin Chen, Bin Cheng, Yi-Xin Yang, Aoneng Cao, Jia-Hui Liu, Li-Jing Du, Yuanfang Liu, Yuliang Zhao, Haifang Wang (2013)
Characterization and preliminary toxicity assay of nano-titanium dioxide additive in sugar-coated chewing gum.Small, 9 9-10
J. Moreau, P. Weber, Michael Martin, B. Gilbert, I. Hutcheon, J. Banfield (2007)
Extracellular Proteins Limit the Dispersal of Biogenic NanoparticlesScience, 316
Bing Wu, Yin Wang, Yi-Hsuan Lee, A. Horst, Zhipeng Wang, Da-Ren Chen, R. Sureshkumar, Yinjie Tang (2010)
Comparative eco-toxicities of nano-ZnO particles under aquatic and aerosol exposure modes.Environmental science & technology, 44 4
T. Xia, M. Kovochich, M. Liong, L. Mädler, B. Gilbert, Haibin Shi, Joanne Yeh, J. Zink, A. Nel (2008)
Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties.ACS nano, 2 10
Nadine Kam, T. Jessop, P. Wender, H. Dai (2004)
Nanotube molecular transporters: internalization of carbon nanotube-protein conjugates into Mammalian cells.Journal of the American Chemical Society, 126 22
B. Frei, R. Stocker, L. England, B. Ames (1990)
Ascorbate: the most effective antioxidant in human blood plasma.Advances in experimental medicine and biology, 264
Oda, Suzuki, Wakayama, Yoshida (2000)
Apolipoprotein A-I gene expression is upregulated by polychlorinated biphenyls in rat liver.The Journal of nutritional biochemistry, 11 11-12
A. Prasad (2008)
Clinical, immunological, anti-inflammatory and antioxidant roles of zincExperimental Gerontology, 43
Jun Cai, C. Lücke, Zhongjing Chen, Ye Qiao, E. Klimtchuk, J. Hamilton (2012)
Solution structure and backbone dynamics of human liver fatty acid binding protein: fatty acid binding revisited.Biophysical journal, 102 11
Feng Zhao, Ying‐tong Zhao, Y. Liu, Xueling Chang, Chunying Chen, Yuliang Zhao (2011)
Cellular uptake, intracellular trafficking, and cytotoxicity of nanomaterials.Small, 7 10
Morin Christophe, Simon Nicolas (2006)
Mitochondria: a target for neuroprotective interventions in cerebral ischemia-reperfusion.Current pharmaceutical design, 12 6
B. Guo, Rema Zebda, S. Drake, C. Sayes (2009)
Synergistic effect of co-exposure to carbon black and Fe2O3 nanoparticles on oxidative stress in cultured lung epithelial cellsParticle and Fibre Toxicology, 6
S. Hansen, Evan Michelson, A. Kamper, P. Borling, F. Stuer-Lauridsen, A. Baun (2008)
Categorization framework to aid exposure assessment of nanomaterials in consumer productsEcotoxicology, 17
B. Frei, L. England, B. Ames (1989)
Ascorbate is an outstanding antioxidant in human blood plasma.Proceedings of the National Academy of Sciences of the United States of America, 86 16
S. Sohaebuddin, P. Thevenot, David Baker, J. Eaton, Liping Tang (2010)
Nanomaterial cytotoxicity is composition, size, and cell type dependentParticle and Fibre Toxicology, 7
W. Tatton, C. Olanow (1999)
Apoptosis in neurodegenerative diseases: the role of mitochondria.Biochimica et biophysica acta, 1410 2
J. Meeusen, H. Tomasiewicz, Andrew Nowakowski, D. Petering (2011)
TSQ (6-methoxy-8-p-toluenesulfonamido-quinoline), a common fluorescent sensor for cellular zinc, images zinc proteins.Inorganic chemistry, 50 16
Kuang‐Kai Liu, Chi-Ching Wang, Chia‐Liang Cheng, Jui‐I Chao (2009)
Endocytic carboxylated nanodiamond for the labeling and tracking of cell division and differentiation in cancer and stem cells.Biomaterials, 30 26
Hongbo Shi, R. Magaye, V. Castranova, Jinshun Zhao (2013)
Titanium dioxide nanoparticles: a review of current toxicological dataParticle and Fibre Toxicology, 10
A. Suresh, D. Pelletier, Wei Wang, J. Morrell-Falvey, B. Gu, M. Doktycz (2012)
Cytotoxicity induced by engineered silver nanocrystallites is dependent on surface coatings and cell types.Langmuir : the ACS journal of surfaces and colloids, 28 5
Oshrat Harush-Frenkel, Eva Rozentur, S. Benita, Y. Altschuler (2008)
Surface charge of nanoparticles determines their endocytic and transcytotic pathway in polarized MDCK cells.Biomacromolecules, 9 2
Roslyn Tedja, M. Lim, R. Amal, C. Marquis (2012)
Effects of serum adsorption on cellular uptake profile and consequent impact of titanium dioxide nanoparticles on human lung cell lines.ACS nano, 6 5
Mingshen Xu, D. Fujita, Shoko Kajiwara, T. Minowa, Xianglan Li, Taro Takemura, H. Iwai, N. Hanagata (2010)
Contribution of physicochemical characteristics of nano-oxides to cytotoxicity.Biomaterials, 31 31
B. Halliwell (1996)
Vitamin C: antioxidant or pro-oxidant in vivo?Free radical research, 25 5
Yu Pan, S. Neuss, Annika Leifert, M. Fischler, Fei Wen, U. Simon, G. Schmid, W. Brandau, W. Jahnen-Dechent (2007)
Size-dependent cytotoxicity of gold nanoparticles.Small, 3 11
Yanli Wang, Qiuxia Wu, K. Sui, Xin-xin Chen, Jie Fang, Xuefeng Hu, Minghong Wu, Yuanfang Liu (2013)
A quantitative study of exocytosis of titanium dioxide nanoparticles from neural stem cells.Nanoscale, 5 11
Sheng-Tao Yang, Jia-Hui Liu, Jing Wang, Yuan Yuan, Aoneng Cao, Haifang Wang, Yuanfang Liu, Yuliang Zhao (2010)
Cytotoxicity of zinc oxide nanoparticles: importance of microenvironment.Journal of nanoscience and nanotechnology, 10 12
Karen Lau, W. Mclean, Dominic Williams, C. Howard (2006)
Synergistic interactions between commonly used food additives in a developmental neurotoxicity test.Toxicological sciences : an official journal of the Society of Toxicology, 90 1
A. Weir, P. Westerhoff, L. Fabricius, Kiril Hristovski, N. Goetz (2012)
Titanium dioxide nanoparticles in food and personal care products.Environmental science & technology, 46 4
P. Espitia, N. Soares, J. Coimbra, N. Andrade, R. Cruz, E. Medeiros (2012)
Zinc Oxide Nanoparticles: Synthesis, Antimicrobial Activity and Food Packaging ApplicationsFood and Bioprocess Technology, 5
Weisheng Lin, Yi Xu, Chuan-Chin Huang, Yinfa Ma, Katie Shannon, Da-Ren Chen, Yue-Wern Huang (2009)
Toxicity of nano- and micro-sized ZnO particles in human lung epithelial cellsJournal of Nanoparticle Research, 11
L. Shao, L. Young, Jun-Feng Wang (2005)
Chronic Treatment with Mood Stabilizers Lithium and Valproate Prevents Excitotoxicity by Inhibiting Oxidative Stress in Rat Cerebral Cortical CellsBiological Psychiatry, 58
U. Aksu, R. Bezemer, B. Yavuz, A. Kandil, C. Demirci, C. Ince (2012)
Balanced vs unbalanced crystalloid resuscitation in a near-fatal model of hemorrhagic shock and the effects on renal oxygenation, oxidative stress, and inflammation.Resuscitation, 83 6
M. Heinlaan, A. Ivask, I. Blinova, H. Dubourguier, A. Kahru (2008)
Toxicity of nanosized and bulk ZnO, CuO and TiO2 to bacteria Vibrio fischeri and crustaceans Daphnia magna and Thamnocephalus platyurus.Chemosphere, 71 7
J. Ricci, R. Gottlieb, D. Green (2003)
Caspase-mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosisThe Journal of Cell Biology, 160
Huanhua Wang, R. Wick, B. Xing (2009)
Toxicity of nanoparticulate and bulk ZnO, Al2O3 and TiO2 to the nematode Caenorhabditis elegans.Environmental pollution, 157 4
Yanli Wang, Lulu Yuan, Chenjie Yao, L. Ding, Chenchen Li, Jie Fang, Minghong Wu (2014)
Caseinophosphopeptides cytoprotect human gastric epithelium cells against the injury induced by zinc oxide nanoparticlesRSC Advances, 4
Ajay Kumar, A. Rahal, R. Mandil, A. Prakash (2013)
In vivo antioxidant potential of ascorbic acid against lead and/or cypermethrin-induced oxidative tissue damageToxicological & Environmental Chemistry, 95
A. Martirosyan, A. Bazes, Y. Schneider (2014)
In vitro toxicity assessment of silver nanoparticles in the presence of phenolic compounds – preventive agents against the harmful effect?Nanotoxicology, 8
M. Rincker, G. Hill, J. Link, A. Meyer, J. Rowntree (2005)
Effects of dietary zinc and iron supplementation on mineral excretion, body composition, and mineral status of nursery pigs.Journal of animal science, 83 12
Güunter Oberdürster (2000)
Toxicology of ultrafine particles: in vivo studiesPhilosophical Transactions of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences, 358
Davide Pantarotto, Ravi Singh, D. McCarthy, M. Erhardt, J. Briand, M. Prato, Kostas Kostarelos, A. Bianco (2004)
Functionalized carbon nanotubes for plasmid DNA gene delivery.Angewandte Chemie, 43 39
M. Mortimer, K. Kasemets, A. Kahru (2010)
Toxicity of ZnO and CuO nanoparticles to ciliated protozoa Tetrahymena thermophila.Toxicology, 269 2-3
T. Siegel, D. Hekstra, George Cross (2008)
Analysis of the Trypanosoma brucei cell cycle by quantitative DAPI imaging.Molecular and biochemical parasitology, 160 2
Claudia Andreini, L. Banci, I. Bertini, A. Rosato (2006)
Zinc through the three domains of life.Journal of proteome research, 5 11
At present, safety evaluation standards for nanofood additives are made based on the toxic effects of a single additive. Since the size, surface properties and chemical nature influence the toxicity of nanomaterials, the toxicity may have dramatically changed when nanomaterials are used as food additives in a complex system. Herein, we investigated the combined toxicity of zinc oxide nanoparticles (ZnO NPs) and vitamin C (Vc, ascorbic acid). The results showed that Vc increased the cytotoxicity significantly compared with that of the ZnO only NPs. When the cells were exposed to ZnO NPs at a concentration less than 15 mg L −1 , or to Vc at a concentration less than 300 mg L −1 , there was no significant cytotoxicity, both in the case of gastric epithelial cell line (GES-1) and neural stem cells (NSCs). However, when 15 mg L −1 of ZnO NPs and 300 mg L −1 of Vc were introduced to cells together, the cell viability decreased sharply indicating significant cytotoxicity. Moreover, the significant increase in toxicity was also shown in the in vivo experiments. The dose of the ZnO NPs and Vc used in the in vivo study was calculated according to the state of food and nutrition enhancer standard. After repeated oral exposure to ZnO NPs plus Vc, the injury of the liver and kidneys in mice has been indicated by the change of these indices. These findings demonstrate that the synergistic toxicity presented in a complex system is essential for the toxicological evaluation and safety assessment of nanofood.
Nanoscale – Royal Society of Chemistry
Published: Oct 26, 2014
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.