Reaction-based selections and catalysis-based selections have allowed development of catalytic antibodies with high catalytic activities. Fluorogenic substrates for monitoring bond-forming reactions, which are useful for catalysis-based selections of catalytic antibodies, have been developed recently; substrates for monitoring of cleavage reactions have been employed for some time. Together with dissection of antibody-catalyzed reactions and structures of catalytic antibodies, development of strategies for selection of antibody catalysts with higher catalytic activities should provide desired catalytic antibodies with high catalytic activities.
Annual Reports Section "C" (Physical Chemistry) – Royal Society of Chemistry
Published: Apr 7, 2005