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THE CARDIOTOXIC ACTION OF PREPARATIONS CONTAINING THE OXYGEN-LABILE HEMOLYSIN OF STREPTOCOCCUS PYOGENES

THE CARDIOTOXIC ACTION OF PREPARATIONS CONTAINING THE OXYGEN-LABILE HEMOLYSIN OF STREPTOCOCCUS... 1. The mechanism of sensitization of the isolated frog' heart to a product of the hemolytic streptococcus has been investigated. The sensitization depends upon the release from the isolated heart of a substance which inhibits the action of the cardiotoxin. The inhibitor is released upon the first (sensitizing) administration of cardiotoxin, but not upon the second (contracture-producing) administration. 2. The inhibitor released by the heart neutralizes the lethal factor present in the streptococcal preparation employed. 3. Some of the properties of the inhibitor have been investigated. Footnotes Submitted: 27 December 1944 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Experimental Medicine Rockefeller University Press

THE CARDIOTOXIC ACTION OF PREPARATIONS CONTAINING THE OXYGEN-LABILE HEMOLYSIN OF STREPTOCOCCUS PYOGENES

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Publisher
Rockefeller University Press
Copyright
© 1945 Rockefeller University Press
ISSN
0022-1007
eISSN
1540-9538
DOI
10.1084/jem.81.3.307
Publisher site
See Article on Publisher Site

Abstract

1. The mechanism of sensitization of the isolated frog' heart to a product of the hemolytic streptococcus has been investigated. The sensitization depends upon the release from the isolated heart of a substance which inhibits the action of the cardiotoxin. The inhibitor is released upon the first (sensitizing) administration of cardiotoxin, but not upon the second (contracture-producing) administration. 2. The inhibitor released by the heart neutralizes the lethal factor present in the streptococcal preparation employed. 3. Some of the properties of the inhibitor have been investigated. Footnotes Submitted: 27 December 1944

Journal

The Journal of Experimental MedicineRockefeller University Press

Published: Mar 1, 1945

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