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J. Kimura, A. Noma, H. Irisawa (1986)
Na-Ca exchange current in mammalian heart cellsNature, 319
D. Bers (1985)
Ca influx and sarcoplasmic reticulum Ca release in cardiac muscle activation during postrest recovery.The American journal of physiology, 248 3 Pt 2
(1984)
Excitation-contraction coupling in rested-state contractions of guinea-pig ventricular myocardium. Naunya-Schmiedeberg's Archives of Pharmacology
A. Fabiato (1981)
Myoplasmic free calcium concentration reached during the twitch of an intact isolated cardiac cell and during calcium-induced release of calcium from the sarcoplasmic reticulum of a skinned cardiac cell from the adult rat or rabbit ventricleThe Journal of General Physiology, 78
A. Fabiato, F. Fabiato (1975)
Contractions induced by a calcium‐triggered release of calcium from the sarcoplasmic reticulum of single skinned cardiac cells.The Journal of Physiology, 249
M. Schneider (1986)
Voltage-dependent mobilization of intracellular calcium in skeletal muscle.Ciba Foundation symposium, 122
I. Josephson, J. Sánchez-Chapula, A. Brown (1984)
Early Outward Current in Rat Single Ventricular CellsCirculation Research, 54
E. Ríos, G. Brum (1987)
Involvement of dihydropyridine receptors in excitation–contraction coupling in skeletal muscleNature, 325
A. Wong, A. Fabiato, J. Bassingthwaighte (1987)
Model of Ca release mechanism from the sarcoplasmic reticulum: Ca-mediated activation, inactivation and reactivation
N. Cohen, W. Lederer (1988)
Changes in the calcium current of rat heart ventricular myocytes during development.The Journal of Physiology, 406
(1988)
Electromechanical properties of isolated feline myocytes
B. London, J. Krueger (1986)
Contraction in voltage-clamped, internally perfused single heart cellsThe Journal of General Physiology, 88
(1988)
The relationship of calcium current , sarcoplasmic reticulum function and contraction in single rat ventricular myocytes excited in the rested state
D. Bers (1987)
Ryanodine and the calcium content of cardiac SR assessed by caffeine and rapid cooling contractures.The American journal of physiology, 253 3 Pt 1
L. Bárcenas-Ruiz, W. Wier (1987)
Voltage dependence of intracellular [Ca2+]i transients in guinea pig ventricular myocytes.Circulation research, 61 1
A. Fabiato (1985)
Time and calcium dependence of activation and inactivation of calcium- induced release of calcium from the sarcoplasmic reticulum of a skinned canine cardiac Purkinje cellThe Journal of General Physiology, 85
(1988)
Calcium current couples
A. Fabiato (1985)
Rapid ionic modifications during the aequorin-detected calcium transient in a skinned canine cardiac Purkinje cellThe Journal of General Physiology, 85
F. Lai, H. Erickson, É. Rousseau, Qi-Yi Liu, G. Meissner (1988)
Purification and reconstitution of the calcium release channel from skeletal muscleNature, 331
M. Inui, A. Saito, S. Fleischer (1987)
Purification of the ryanodine receptor and identity with feet structures of junctional terminal cisternae of sarcoplasmic reticulum from fast skeletal muscle.The Journal of biological chemistry, 262 4
L. Bárcenas-Ruiz, D. Beuckelmann, W. Wier (1987)
Sodium-calcium exchange in heart: membrane currents and changes in [Ca2+]i.Science, 238 4834
W. Gibbons, H. Fozzard (1975)
Relationships between voltage and tension in sheep cardiac Purkinje fibersThe Journal of General Physiology, 65
Geert Callewaert, L. Cleemann, Martin Morad (1988)
Epinephrine enhances Ca2+ current-regulated Ca2+ release and Ca2+ reuptake in rat ventricular myocytes.Proceedings of the National Academy of Sciences of the United States of America, 85 6
M. Mitchell, T. Powell, D. Terrar, V. Twist (1987)
Calcium‐activated inward current and contraction in rat and guinea‐pig ventricular myocytes.The Journal of Physiology, 391
P. Anderson, A. Manring, J. Sommer, E. Johnson (1976)
Cardiac muscle: an attempt to relate structure to function.Journal of molecular and cellular cardiology, 8 2
(1988)
Epinephrine enhances Ca ~+ current-regulated
M. Mitchell, T. Powell, D. Terrar, V. Twist (1987)
Electrical activity and contraction in cells isolated from rat and guinea‐pig ventricular muscle: a comparative study.The Journal of Physiology, 391
(1970)
1970b. The relation between potential, membrane currents
S. Sheu, V. Sharma, A. Uglesity (1986)
Na+-Ca2+ exchange contributes to increase of cytosolic Ca2+ concentration during depolarization in heart muscle.The American journal of physiology, 250 4 Pt 1
R. Hansford, E. Lakatta (1987)
Ryanodine releases calcium from sarcoplasmic reticulum in calcium‐tolerant rat cardiac myocytes.The Journal of Physiology, 390
M. Mitchell, T. Powell, D. Terrar, V. Twist (1983)
Characteristics of the second inward current in cells isolated from rat ventricular muscleProceedings of the Royal Society of London. Series B. Biological Sciences, 219
(1981)
Improved patch-damp techniques for high-resolution current recording from cells and cell-free membrane patches. Pfl~gers Archly
M. Nabauer, G. Callewaert, L. Cleemann, M. Morad (1989)
Regulation of calcium release is gated by calcium current, not gating charge, in cardiac myocytes.Science, 244 4906
M. Capogrossi, A. Kort, H. Spurgeon, E. Lakatta (1986)
Single adult rabbit and rat cardiac myocytes retain the Ca2+- and species-dependent systolic and diastolic contractile properties of intact muscleThe Journal of General Physiology, 88
M. Cannell, Berlin, W. Lederer (1987)
Effect of membrane potential changes on the calcium transient in single rat cardiac muscle cells.Science, 238 4832
I. Josephson, J. Sánchez-Chapula, A. Brown (1984)
A Comparison of Calcium Currents in Rat and Guinea Pig Single Ventricular CellsCirculation Research, 54
N. Cohen, W. Lederer (1987)
Calcium current in isolated neonatal rat ventricular myocytes.The Journal of Physiology, 391
K. Lee, R. Tsein (1982)
Reversal of current through calcium channels in dialysed single heart cellsNature, 297
The relationship between the cytosolic Ca 2 + transient and cell length during the twitch in single adult cardiac myocytes
G. Langer (1982)
Sodium-calcium exchange in the heart.Annual review of physiology, 44
J. Sutko, K. Ito, J. Kenyon (1985)
Ryanodine: a modifier of sarcoplasmic reticulum calcium release in striated muscle.Federation proceedings, 44 15
B. Block, T. Imagawa, K. Campbell, C. Franzini-armstrong (1988)
Structural evidence for direct interaction between the molecular components of the transverse tubule/sarcoplasmic reticulum junction in skeletal muscleThe Journal of Cell Biology, 107
D. Beuckelmann, W. Wier (1988)
Mechanism of release of calcium from sarcoplasmic reticulum of guinea‐pig cardiac cells.The Journal of Physiology, 405
G. Beeler, H. Reuter (1970)
The relation between membrane potential, membrane currents and activation of contraction in ventricular myocardial fibresThe Journal of Physiology, 207
(1985)
1985b. Time and calcium dependence of activation ancl inactivation of calcium-induced
M. Poenie, J. Alderton, R. Steinhardt, R. Tsien (1986)
Calcium rises abruptly and briefly throughout the cell at the onset of anaphase.Science, 233 4766
BY Beeler, H. Reuter (1970)
Membrane calcium current in ventricular myocardial fibresThe Journal of Physiology, 207
F. Lai, H. Erickson, B. Block, G. Meissner (1987)
Evidence for a junctional feet-ryanodine receptor complex from sarcoplasmic reticulum.Biochemical and biophysical research communications, 143 2
G. Isenberg (1982)
Ca Entry and Contraction as Studied in Isolated Bovine Ventricular MyocytesZeitschrift für Naturforschung C, 37
Single rat ventricular myocytes, voltage-clamped at -50 to -40 mV, were depolarized in small steps in order to define the mechanisms that govern the increase in cytosolic Ca2+ (Cai) and contraction, measured as a reduction in myocyte length. Small (3-5 mV), sustained (seconds) depolarizations that caused a small inward or no detectable change in current were followed after a delay by small (less than 2% of the resting length), steady reductions in cell length measured via a photodiode array, and small, steady increases in Cai measured by changes in Indo-1 fluorescence. Larger (greater than -30 and less than -20 mV), sustained depolarizations produced phasic Ca2+ currents, Cai transients, and twitch contractions, followed by a steady current and a steady increase in Cai and contraction. Nitrendipine (or Cd, verapamil, or Ni) abolished the steady contraction and always produced an outward shift in steady current. The steady, nitrendipine-sensitive current and sustained increase in Cai and contraction exhibited a similar voltage dependence over the voltage range between -40 and -20 mV. 2 microM ryanodine in the presence of intact Ca2+ channel activity also abolished the steady increase in Cai and contraction over this voltage range. We conclude that when a sustained depolarization does not exceed about -20 mV, the resultant steady, graded contraction is due to SR Ca2+ release graded by a steady ("window") Ca2+ current. The existence of appreciable, sustained, graded Ca2+ release in response to Ca2+ current generated by arbitrarily small depolarizations is not compatible with any model of Ca2(+)-induced Ca2+ release in which the releasing effect of the Ca2+ channel current is mediated solely by Ca2+ entry into a common cytosolic pool. Our results therefore imply a distinction between the triggering and released Ca2+ pools.
The Journal of General Physiology – Rockefeller University Press
Published: Nov 1, 1990
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