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STUDIES ON THE DENATURATION OF ANTIBODY

STUDIES ON THE DENATURATION OF ANTIBODY The specific rate of inactivation of antitoxin in urea solutions, as measured by the Römer neutralization test with toxin, has been shown to be independent of the concentration of protein under the conditions studied. The amount of precipitate obtained in the quantitative precipitation test with toxin, however, increases greatly with increasing protein concentration during denaturation. The time during which the protein concentration is important in this respect has been shown to be the interval in which the urea is being dialyzed from the solutions. The meaning of the results is discussed. Footnotes Submitted: 2 April 1945 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Experimental Medicine Rockefeller University Press

STUDIES ON THE DENATURATION OF ANTIBODY

The Journal of Experimental Medicine , Volume 81 (6): 647 – Jun 1, 1945

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References (12)

Publisher
Rockefeller University Press
Copyright
© 1945 Rockefeller University Press
ISSN
0022-1007
eISSN
1540-9538
DOI
10.1084/jem.81.6.647
Publisher site
See Article on Publisher Site

Abstract

The specific rate of inactivation of antitoxin in urea solutions, as measured by the Römer neutralization test with toxin, has been shown to be independent of the concentration of protein under the conditions studied. The amount of precipitate obtained in the quantitative precipitation test with toxin, however, increases greatly with increasing protein concentration during denaturation. The time during which the protein concentration is important in this respect has been shown to be the interval in which the urea is being dialyzed from the solutions. The meaning of the results is discussed. Footnotes Submitted: 2 April 1945

Journal

The Journal of Experimental MedicineRockefeller University Press

Published: Jun 1, 1945

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