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STUDIES ON PATHOGENIC B. COLI FROM BOVINE SOURCES

STUDIES ON PATHOGENIC B. COLI FROM BOVINE SOURCES On agar plates certain strains of B. coli from the ileum of calves suffering from diarrhea or scours promptly mutate and give rise to forms which have lost capsular substance, whose virulence has been greatly reduced, and which have gained very greatly in agglutinability and in being taken up by leucocytes. The original characters are not regained in cultures kept in the cold after development, nor in rapid transfers in bouillon, nor in passages through the peritoneal cavity of guinea pigs. Filtrates of 48 hour bouillon cultures contain as much toxin in the (b) as in the (a) form indicating no loss in this function. Footnotes Submitted: 17 March 1927 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Experimental Medicine Rockefeller University Press

STUDIES ON PATHOGENIC B. COLI FROM BOVINE SOURCES

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Publisher
Rockefeller University Press
Copyright
© 1927 Rockefeller University Press
ISSN
0022-1007
eISSN
1540-9538
DOI
10.1084/jem.46.1.133
Publisher site
See Article on Publisher Site

Abstract

On agar plates certain strains of B. coli from the ileum of calves suffering from diarrhea or scours promptly mutate and give rise to forms which have lost capsular substance, whose virulence has been greatly reduced, and which have gained very greatly in agglutinability and in being taken up by leucocytes. The original characters are not regained in cultures kept in the cold after development, nor in rapid transfers in bouillon, nor in passages through the peritoneal cavity of guinea pigs. Filtrates of 48 hour bouillon cultures contain as much toxin in the (b) as in the (a) form indicating no loss in this function. Footnotes Submitted: 17 March 1927

Journal

The Journal of Experimental Medicine – Rockefeller University Press

Published: Jul 1, 1927

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