B R I E r N O â¢ ~ S merely d o r m a n t myoblasts that failed to fuse with other myoblasts and are ready to recapitulate the embryonic development of skeletal muscle fiber when the main multinucleate cell is damaged. O f course, t h a t b o t h mechanisms m i g h t be operating simultaneously as the source of the "free" cells is, indeed, a further possibility since one mechanism need not preclude the other. A third possibility is that the satellite cells are " w a n d e r i n g " cells that have penetrated the basem e n t m e m b r a n e and are lying u n d e r n e a t h it ready to be mobilized into activity u n d e r the proper conditions. T h e correct explanation of the origin and role of the satellite cells must await the outcome of further studies3 1 A thorough search of both Dr. Palade's and Dr. Moore's collection of electron micrographs of cardiac muscle have not revealed either peripheral nuclei or satellite cells.
The Journal of Cell Biology – Rockefeller University Press
Published: Feb 1, 1961
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