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- Publisher
- Rockefeller University Press
- Copyright
- © 1973 Rockefeller University Press
- ISSN
- 0022-1295
- eISSN
- 1540-7748
- DOI
- 10.1085/jgp.61.3.385
- Publisher site
- See Article on Publisher Site
Abstract
K + -sensitive liquid ion-exchanger microelectrodes are shown to be capable of measuring concentration changes which occur on a millisecond time scale. However, some quaternary ammonium ions, such as tetraethylammonium and acetylcholine, are able to block electrode function when present in concentrations as low as 10 -4 to 10 -3 M. Changes in extracellular potassium concentration caused by spike activity or voltage clamp pulses of exposed single neurons of the snail Helix pomatia may be measured by these electrodes. Quantitative analysis shows that the total amount of excess potassium found in the vicinity of the cell a short time after a clamp pulse, is in relatively good agreement with the amount of potassium carried by the membrane current. Footnotes Submitted: 7 September 1972
Journal
The Journal of General Physiology – Rockefeller University Press
Published: Mar 1, 1973