Loading next page...
/lp/rockefeller-university-press/mannose-receptor-and-its-putative-ligands-in-normal-murine-lymphoid-8dVmZ4QuSp
- Publisher
- Rockefeller University Press
- Copyright
- © 1999 Rockefeller University Press
- ISSN
- 0022-1007
- eISSN
- 1540-9538
- DOI
- 10.1084/jem.189.12.1961
- Publisher site
- See Article on Publisher Site
Abstract
The mannose receptor (MR) has established roles in macrophage (Mφ) phagocytosis of microorganisms and endocytic clearance of host-derived glycoproteins, and has recently been implicated in antigen capture by dendritic cells (DCs) in vitro. MR is the founder member of a family of homologous proteins, and its recognition properties differ according to its tissue of origin. Given this heterogeneity and our recent discovery of a soluble form of MR in mouse serum, we studied the sites of synthesis of MR mRNA and expression of MR protein in normal mouse tissues. We demonstrate that synthesis and expression occur at identical sites, and that mature Mφ and endothelium are heterogeneous with respect to MR expression, additionally describing MR on perivascular microglia and glomerular mesangial cells. However, MR was not detected on DCs in situ, or on marginal zone or subcapsular sinus Mφ, both of which have MR-like binding activities. We also compared expression of MR to the binding of a recombinant probe containing the cysteine-rich domain of MR. We show that MR and its putative ligand(s) are expressed at nonoverlapping sites within lymphoid organs, consistent with a transfer function for soluble MR. Therefore, in addition to endocytic and phagocytic roles, MR may play an important role in antigen recognition and transport within lymphoid organs. mannose receptor macrophage dendritic cell endothelium mesangial cell Footnotes Abbreviations used in this paper: CR cysteine-rich domain of MR DC dendritic cell ICC immunocytochemistry ISH in situ hybridization MHCII major histocompatibility complex class II Mφ macrophage(s) MR mannose receptor Sn sialoadhesin sMR soluble MR Submitted: 26 March 1999
Journal
The Journal of Experimental Medicine – Rockefeller University Press
Published: Jun 21, 1999
Recommended Articles
Loading...
References
-
Plasma clearance of glycoproteins with terminal mannose and N-acetylglucosamine by liver non-parenchymal cells. Studies with beta-glucuronidase, N-acetyl-beta-D-glucosamine, ribonuclease B and agalacto-orosomucoidSchlesinger
-
An electron microscope autoradiographic study of the carbohydrate recognition systems in rat liverHubbard
-
Evidence for receptor-mediated binding of glycoproteins, glycoconjugates, and lysosomal glycosidases by alveolar macrophagesStahl
-
Expression of a mannosyl-fucosyl receptor for endocytosis on cultured primary macrophages and their hybridsStahl
-
Characterization of the mannose/fucose receptor on human mononuclear phagocytesShepherd
-
Dexamethasone increases expression of mannose receptors and decreases extracellular lysosomal enzyme accumulation in macrophagesShepherd
-
Isolation and characterization of a mannose receptor from human pigment epitheliumShepherd
-
Human macrophage activation. Modulation of mannosyl, fucosyl receptor activity in vitro by lymphokines, gamma and alpha interferons, and dexamethasoneMokoena
-
IL-4 potently enhances macrophage mannose receptor (MMR) activity in mouse peritoneal macrophagesStein
-
Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor αSallusto
-
CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to granulocyte-macrophage colony-stimulating factor plus tumor necrosis factor alpha. II. Functional analysisCaux
-
Phagocytosis of antigens by Langerhans cells in vitroReis e Sousa
-
Human epidermal Langerhans cells express the mannose-fucose binding receptorCondaminet
-
Trypanosoma cruziamastigote adhesion to macrophage is facilitated by the mannose receptorKahn
-
Glycosyl receptors in macrophage subpopulations of rat spleen and lymph nodeHarms
-
Chemical definition of an epitope/adhesin molecule on Candida albicans.Li
-
Tissue plasminogen activator is endocytosed by mannose and galactose receptors of rat liver cellsSmedsrød
-
Characterization of the interaction both in vitro and in vivo of tissue-type plasminogen activator (t-PA) with rat liver cells. Effects of monoclonal antibodies to t-PAOtter
-
Nonopsonic phagocytosis of microorganismsOfek
-
Molecular characterization of the human macrophage mannose receptor: demonstration of multiple carbohydrate domains and phagocytosis of yeasts in Cos-1 cellsEzekowitz
-
Uptake of Pneumocystis cariniimediated by the macrophage mannose receptorEzekowitz
-
Modulation of macrophage mannosyl-specific receptors by cultivation on immobilized zymosan. Effects on superoxide-anion release and phagocytosisBerton
-
Involvement of mannose receptor in cytokine interleukin-1 (IL-1), IL-6, and granulocyte-macrophage colony-stimulating factor responses, but not in chemokine macrophage inflammatory protein 1 (MIP-1), MIP-2, and KC responses, caused by attachment of Candida albicansto macrophagesYamamoto
-
Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial productsSallusto
-
The mannose receptor functions as a high capacity and broad specificity antigen receptor in human dendritic cellsEngering
-
Mannose receptor-mediated uptake of antigens strongly enhances HLA class II-restricted antigen presentation by cultured dendritic cellsTan
-
The mannose receptor delivers lipoglycan antigens to endosomes for presentation to T cells by CD1b moleculesPrigozy
-
Structural requirements for high affinity binding of complex ligands by the mannose receptorTaylor
-
The exon-intron structure and chromosomal localization of the mouse macrophage mannose receptor gene Mrc1: identification of a Ricin-like domain at the N-terminus of the receptorHarris
-
Fc chimeric protein containing the cysteine-rich domain of the murine mannose receptor binds to macrophages from splenic marginal zone and lymph node subcapsular sinus and to germinal centersMartínez-Pomares
-
A functional soluble form of the murine mannose receptor is produced by macrophages in vitroand is present in mouse serumMartínez-Pomares
-
Isolation of the SO4-4-GalNAcβ1,4GlcNAcβ1,2Manα-specific receptor from rat liverFiete
-
The macrophage/endothelial cell mannose receptor cDNA encodes a protein that binds oligosaccharides terminating with SO4-4-GalNAcβ1,4GlcNAc or Man at independent sitesFiete
-
A cysteine-rich domain of the “mannose” receptor mediates GalNAc-4-SO4bindingFiete
-
Molecular cloning of pancreatic group I phospholipase A2 receptorIshizaki
-
The human 180 kDa receptor for secretory phospholipases A2Ancian
-
Langerhans cells, veiled cells, and interdigitating cells in the mouse recognized by a monoclonal antibodyKraal
-
The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processingJiang
-
Characterization of a novel member of the macrophage mannose receptor type C lectin familyWu
-
Kaposi's sarcoma cells express the macrophage-associated antigen mannose receptor and develop in peripheral blood cultures of Kaposi's sarcoma patientsUccini
-
Monoclonal antibodies against the human mannose receptor as a specific marker in flow cytometry and immunohistochemistry for macrophagesNoorman
-
Distribution of murine mannose receptor expression from early embryogenesis through to adulthoodTakahashi
-
Evidence that mannose recognition by splenic sinusoidal cells plays a role in the splenic entry of lymphocytesWeston
-
Control of thymus physiology by peptidic hormones and neuropeptidesDardenne
-
Involvement of specific macrophage-lineage cells surrounding arterioles in barrier and scavenger function in brain cortexMato
-
Liposome targeting to mouse brain: mannose as a recognition markerUmezawa
-
Mannose dependent tightening of the rat ependymal cell barrier. In vivo and in vitrostudy using neoglycoproteinsKuchler
-
TNF-α and IL-1α induce mannose receptors and apoptosis in glomerular mesangial but not endothelial cellsLiu
-
Circulating C-terminal propeptide of type I procollagen is cleared mainly via the mannose receptor in liver endothelial cellsSmedsrød
-
Glomerular mesangial cells and inflammatory macrophages ingest neutrophils undergoing apoptosisSavill
-
The activated mesangial cell: a glomerular “myofibroblast”?Johnson
-
Functional expression of NADPH oxidase components (α- and β-subunits of cytochrome b558 and 45-kDa flavoprotein) by intrinsic human glomerular mesangial cellsRadeke
-
Intrinsic human glomerular mesangial cells can express receptors for IgG complexes (FcγRIII-A) and the associated FcεRI γ-chainRadeke
-
Failure of blood-island formation and vasculogenesis in Flk-1-deficient miceShalaby
-
Ligand-dependent development of the endothelial and hemopoietic lineages from embryonic mesodermal cells expressing vascular endothelial growth factor 2Eichmann
-
Murine macrophage mannose receptor is regulated by the transcription factors PU.1 and SP1Eichbaum
-
Marginal zone macrophages in the mouse spleen identified by a monoclonal antibody. Anatomical correlation with a B cell subpopulationVan Vliet
-
Differential expression of murine macrophage surface glycoprotein antigens in intra-cellular membranesSmith
-
F4/80, a monoclonal antibody directed specifically against the mouse macrophageAustyn
-
A shared alloantigenic determinant on Ia antigens encoded by the I-A and I-E subregions: evidence for I region gene duplicationBhattacharya
-
Purification and characterization of the D-mannose receptor from J774 mouse macrophage cellsBlum
-
The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodiesMetlay
-
Properties and distribution of a lectin-like haemagglutinin differentially expressed by stromal tissue macrophagesCrocker
@Phil_Robichaud
@deepthiw
@JoseServera