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Gut bacteria side-step lymph nodes

Gut bacteria side-step lymph nodes <h2>Gut bacteria side-step lymph nodes</h2> Dissemination of gut bacteria to the liver and spleen of mice is comparable in the presence (closed triangles) and absence (open triangles) of Peyer's patches. Invasive bacteria can take more than one route from the gut to distant organs, say Barnes and colleagues on page 1591 . According to conventional wisdom, pathogenic gut bacteria spread to distant tissues via an orderly march from gut to local lymph nodes (LNs) and then on to distant organs. But some mutant bugs that cannot invade the lymphoid tissues of the gut can still spread, hinting at the existence of an alternative route. Barnes and colleagues infected mice orally with Yersinia pseudotuberculosis. They noted two waves of bacteria that spread to both the spleen and liver in the infected mice. The first wave occurred within 30 minutes of infection and was rapidly cleared from these distant organs. The second began later and stuck around. Only the second wave of bacteria side-stepped the LNs, as mice lacking Peyer's patches—the gut lymphoid tissue that bacteria traverse to reach the LNs—developed only late-stage infections in the liver and spleen. Marking individual bacteria with unique oligonucleotide tags revealed that the bugs http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Experimental Medicine Rockefeller University Press

Gut bacteria side-step lymph nodes

The Journal of Experimental Medicine , Volume 203 (6): 1387 – Jun 12, 2006

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Publisher
Rockefeller University Press
Copyright
© 2006 Rockefeller University Press
ISSN
0022-1007
eISSN
1540-9538
DOI
10.1084/jem.2036iti5
Publisher site
See Article on Publisher Site

Abstract

<h2>Gut bacteria side-step lymph nodes</h2> Dissemination of gut bacteria to the liver and spleen of mice is comparable in the presence (closed triangles) and absence (open triangles) of Peyer's patches. Invasive bacteria can take more than one route from the gut to distant organs, say Barnes and colleagues on page 1591 . According to conventional wisdom, pathogenic gut bacteria spread to distant tissues via an orderly march from gut to local lymph nodes (LNs) and then on to distant organs. But some mutant bugs that cannot invade the lymphoid tissues of the gut can still spread, hinting at the existence of an alternative route. Barnes and colleagues infected mice orally with Yersinia pseudotuberculosis. They noted two waves of bacteria that spread to both the spleen and liver in the infected mice. The first wave occurred within 30 minutes of infection and was rapidly cleared from these distant organs. The second began later and stuck around. Only the second wave of bacteria side-stepped the LNs, as mice lacking Peyer's patches—the gut lymphoid tissue that bacteria traverse to reach the LNs—developed only late-stage infections in the liver and spleen. Marking individual bacteria with unique oligonucleotide tags revealed that the bugs

Journal

The Journal of Experimental MedicineRockefeller University Press

Published: Jun 12, 2006

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