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- Publisher
- Rockefeller University Press
- Copyright
- Copyright © 1962 by The Rockefeller University Press
- ISSN
- 0021-9525
- eISSN
- 1540-8140
- DOI
- 10.1083/jcb.12.2.433
- Publisher site
- See Article on Publisher Site
Abstract
W. THOENES. From the Department of Pathology, University of Wtirzburg, Germany In electron microscopic investigations on the proximal tubule of the mouse kidney, large osmiophilic granules in the cytoplasm of the epithelial cells have been found by various authors (2, 13, 14, 20). Rhodin (13) and Clark (2) have pointed out that the granules contain concentric lamellae, but there have been no further investigations on the fine structure of these granules so far. Recently Miller (10) described granules which show a regular pattern of layered dense and light bands with a repeating period of about 80 to 90 A. In our electron microscopic investigations on the proximal tubule cells of the k i d n e y / w e observed similar granules which show in some respects a different structure. The granules which will be described were found in almost every epithelial cell of the proximal tubule, chiefly in the apical and intermediate zones of the cell. In one of three animals examined, every cell in one section contained 3 to 15 granules; in the other two animals there were only 1 to 2 granules in each cell. This difference did not appear to be related to
Journal
The Journal of Cell Biology – Rockefeller University Press
Published: Feb 1, 1962