Properties o f Fibronectins The basic properties of fibronectins are listed in Table II. The molecule is asymmetric and consists of two similar or identical subunits of molecular weight 220,000 +__20,000 daltons held together by disulfide-bonding near their carboxyl termini. Biophysical measurements indicate that, although the molecule as a whole is flexible, it contains compact globular domains (23, 24). Electron microscopic results confirm the idea that the molecule is extended and flexible (25-27), although the globular domains have not yet been observed by this technique. One important characteristic of fibronectins is that they are capable of interacting specifically with a wide variety of other macromolecules. Table III lists the various interactions, some of which have been studied in more detail than others. The best-established interactions, for which evidence exists both for their occurrence in vivo and for their specificity in vitro, are the interactions with gelatin and collagens, fibrin, factor XIIIa transglutaminase, heparin, and proteoglycans. In addition, it is clear that fibronectins interact with many cells; however, the molecular basis for this interaction remains unclear and is one of the major unanswered questions concerning fibronectins. The binding sites on fibronectins involved in many of these interactions have been
The Journal of Cell Biology – Rockefeller University Press
Published: Oct 1, 1982
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera