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EXCITATION THEORIES OF RASHEVSKY AND HILL

EXCITATION THEORIES OF RASHEVSKY AND HILL (Accepted for publication, April 23, 1937) Blair (1932) proposed the equation dp/dt = KZ - kp (1) to describe the change of the excitatory process of nerve, p, under the action of a current I. K and k are constants, and action results when p exceeds some threshold value h. The equation fits extensive experimental data but is quite unable to account for the anodic excitation at break and for non-excitation by slowly rising currents. Rashevsky (1933) added a parallel equation for an inhibitory process, or threshold rise, ~e/dt = KZ k(e Co) (2) ~ilgt Mx - m(i - io) (3) where K, k, M, and m are constants, e the excitatory process, and i the inhibitory one. Action results when e _>- i; and for m < < k and K / k < M / m ( . ' . M < < K ) , the negative process, t h a t is, slower than the positive one, these equations satisfy the two phenomena not covered by Blair's treatment as well as those which are. These equations can also be given a physical interpretation in terms of the migration of two antagonistic ions, e and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of General Physiology Rockefeller University Press

EXCITATION THEORIES OF RASHEVSKY AND HILL

Franklin Offner
The Journal of General Physiology , Volume 21 (1): 89 – Sep 1, 1937
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Publisher
Rockefeller University Press
Copyright
Copyright © 1937 by The Rockefeller University Press
ISSN
0022-1295
eISSN
1540-7748
DOI
10.1085/jgp.21.1.89
Publisher site
See Article on Publisher Site

Abstract

(Accepted for publication, April 23, 1937) Blair (1932) proposed the equation dp/dt = KZ - kp (1) to describe the change of the excitatory process of nerve, p, under the action of a current I. K and k are constants, and action results when p exceeds some threshold value h. The equation fits extensive experimental data but is quite unable to account for the anodic excitation at break and for non-excitation by slowly rising currents. Rashevsky (1933) added a parallel equation for an inhibitory process, or threshold rise, ~e/dt = KZ k(e Co) (2) ~ilgt Mx - m(i - io) (3) where K, k, M, and m are constants, e the excitatory process, and i the inhibitory one. Action results when e _>- i; and for m < < k and K / k < M / m ( . ' . M < < K ) , the negative process, t h a t is, slower than the positive one, these equations satisfy the two phenomena not covered by Blair's treatment as well as those which are. These equations can also be given a physical interpretation in terms of the migration of two antagonistic ions, e and

Journal

The Journal of General Physiology – Rockefeller University Press

Published: Sep 1, 1937

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