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DIFFERENT LETHAL EFFECTS OF MITOMYCIN C AND ACTINOMYCIN D DURING THE DIVISION CYCLE OF HELA CELLS

DIFFERENT LETHAL EFFECTS OF MITOMYCIN C AND ACTINOMYCIN D DURING THE DIVISION CYCLE OF HELA CELLS The lethal actions of mitomycin C and actinomycin D were followed during the division cycle of HeLa cells. The cells were most susceptible to a 2 hr pulse of mitomycin C during the G 1 phase, whereas their sensitivity to actinomycin D was most pronounced in the S phase. Posttreatment of the cells with acetoxycycloheximide, a potent inhibitor of protein synthesis, increased the survival (colony-forming ability) of cells treated with mitomycin C but had very little effect on the survival of cells treated with actinomycin D. The significance of these findings is discussed. Footnotes Submitted: 8 January 1968 Revision received 3 May 1968 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Cell Biology Rockefeller University Press

DIFFERENT LETHAL EFFECTS OF MITOMYCIN C AND ACTINOMYCIN D DURING THE DIVISION CYCLE OF HELA CELLS

The Journal of Cell Biology , Volume 38 (3): 477 – Sep 1, 1968

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Publisher
Rockefeller University Press
Copyright
© 1968 Rockefeller University Press
ISSN
0021-9525
eISSN
1540-8140
DOI
10.1083/jcb.38.3.477
Publisher site
See Article on Publisher Site

Abstract

The lethal actions of mitomycin C and actinomycin D were followed during the division cycle of HeLa cells. The cells were most susceptible to a 2 hr pulse of mitomycin C during the G 1 phase, whereas their sensitivity to actinomycin D was most pronounced in the S phase. Posttreatment of the cells with acetoxycycloheximide, a potent inhibitor of protein synthesis, increased the survival (colony-forming ability) of cells treated with mitomycin C but had very little effect on the survival of cells treated with actinomycin D. The significance of these findings is discussed. Footnotes Submitted: 8 January 1968 Revision received 3 May 1968

Journal

The Journal of Cell BiologyRockefeller University Press

Published: Sep 1, 1968

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