Cell Death Regulation in Drosophila <h3>Conservation of Mechanism and Unique Insights</h3> Stephanie Y. Vernooy a , Jeffrey Copeland a , Nazli Ghaboosi a , Erik E. Griffin a , Soon Ji Yoo a , and Bruce A. Hay a Division of Biology, MC156-29, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125. Fax: (626) 449-0756 Phone: (626) 395-3399 Email: firstname.lastname@example.org a Division of Biology, MC156-29, California Institute of Technology, Pasadena, California 91125 Programmed cell death, or apoptosis, is a genetically encoded form of cell suicide that results in the orderly death and phagocytic removal of excess, damaged, or dangerous cells during normal development and in the adult. The cellular machinery required to carry out apoptosis is present in most, if not all cells, but is only activated in cells instructed to die (for review see Jacobson et al. 1997 ). Here, we review cell death regulation in the fly in the context of a first pass look at the complete Drosophila genome and what is known about death regulation in other organisms, particularly worms and vertebrates. Next Section <h3>Caspases: The Core of the Cell Death Machine</h3> The caspase family of cysteine proteases is central to apoptotic
The Journal of Cell Biology – Rockefeller University Press
Published: Jul 24, 2000
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