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- Publisher
- Rockefeller University Press
- Copyright
- © 2015 Good-Jacobson et al.
- ISSN
- 0022-1007
- eISSN
- 1540-9538
- DOI
- 10.1084/jem.20150191
- pmid
- 26077717
- Publisher site
- See Article on Publisher Site
Abstract
Plasma cell migration is crucial to immunity, but little is known about the molecular regulators of their migratory programs. Here, we detail the critical role of the transcription factor c-Myb in determining plasma cell location. In the absence of c-Myb, no IgG + antigen-specific plasma cells were detected in the bone marrow after immunization or virus infection. This was correlated with a dramatic reduction of plasma cells in peripheral blood, mislocalization in spleen, and an inability of c-Myb–deficient plasma cells to migrate along a CXCL12 gradient. Therefore, c-Myb plays an essential, novel role in establishing the long-lived plasma cell population in the BM via responsiveness to chemokine migration cues. Submitted: 30 January 2015 Accepted: 19 May 2015 This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms ). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/ ).
Journal
The Journal of Experimental Medicine – Rockefeller University Press
Published: Jun 29, 2015