Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

BACTERICIDAL ACTIVITY OF RAT LEUCOCYTIC EXTRACTS

BACTERICIDAL ACTIVITY OF RAT LEUCOCYTIC EXTRACTS The bactericidal substance present in mitochondrial extracts from rat leucocytes was found to be non-dialyzable, fractionated at 30 per cent (NH 4 SO 4 saturation and was able to withstand temperatures up to 100°C. The tentative identification of a lipoprotein as the responsible bactericidal substance is based on various observations; an ultraviolet absorption at a peak associated with alpha, beta unsaturated fatty acids, 205 to 208 mµ, inactivation of the bactericidal substance by ether treatment at –70°C. but not at 0°C. and inhibition of the bactericidal activity with lipase treatment as well as with trypsin. Footnotes Submitted: 27 January 1957 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Experimental Medicine Rockefeller University Press

BACTERICIDAL ACTIVITY OF RAT LEUCOCYTIC EXTRACTS

Loading next page...
 
/lp/rockefeller-university-press/bactericidal-activity-of-rat-leucocytic-extracts-vgniqKiRVf

References (2)

Publisher
Rockefeller University Press
Copyright
© 1957 Rockefeller University Press
ISSN
0022-1007
eISSN
1540-9538
DOI
10.1084/jem.105.6.529
Publisher site
See Article on Publisher Site

Abstract

The bactericidal substance present in mitochondrial extracts from rat leucocytes was found to be non-dialyzable, fractionated at 30 per cent (NH 4 SO 4 saturation and was able to withstand temperatures up to 100°C. The tentative identification of a lipoprotein as the responsible bactericidal substance is based on various observations; an ultraviolet absorption at a peak associated with alpha, beta unsaturated fatty acids, 205 to 208 mµ, inactivation of the bactericidal substance by ether treatment at –70°C. but not at 0°C. and inhibition of the bactericidal activity with lipase treatment as well as with trypsin. Footnotes Submitted: 27 January 1957

Journal

The Journal of Experimental MedicineRockefeller University Press

Published: Jun 1, 1957

There are no references for this article.