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H 2 O 2 formation by Streptococcus mitis was measured by the catalase-dependent conversion of 14 Cformate to 14 CO 2 ; it was optimal at pH 6.0–6.5 and required glucose. The H 2 O 2 formed by S. mitis could be employed as a component of an antimicrobial system that also included lactoperoxidase (LPO) and either iodide or thiocyanate ions in the concentrations present in saliva. The antimicrobial effect of the LPO-iodide- S. mitis system was measured by the decrease in the viable cell count of the target organisms ( Escherichia coli, Staphylococcus aureus, Candida tropicalis ). The antimicrobial effect of the LPO-thiocyanate- S. mitis system was measured by the decrease in the rate of growth or the rate of uptake of 14 Cvaline by the target organisms ( E. coli, S. aureus ). Mixed or parotid saliva could replace LPO and thiocyanate ions in the S. mitis -dependent inhibition of bacterial growth and valine uptake. The presence in saliva of a peroxidase-mediated, antimicrobial system dependent on microbial metabolism for H 2 O 2 and its role as a natural host defense mechanism are considered. Footnotes Submitted: 5 September 1972
The Journal of Experimental Medicine – Rockefeller University Press
Published: Feb 1, 1973
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