PCSK9 Inhibitors: From Nature's Lessons to Clinical Utility.

PCSK9 Inhibitors: From Nature's Lessons to Clinical Utility. Proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors are a novel class of non-statin lipid lowering therapy that reduce LDL-cholesterol by 50 - 60%. PCSK9 inhibitors decrease LDL-cholesterol by preventing intracellular degradation of LDL receptors; subsequently, a greater number of LDL-receptors are available on the cell surface to extract circulating LDL. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Endocrine, metabolic & immune disorders drug targets Pubmed

PCSK9 Inhibitors: From Nature's Lessons to Clinical Utility.

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PCSK9 Inhibitors: From Nature's Lessons to Clinical Utility.

Endocrine, metabolic & immune disorders drug targets: 1 – Feb 13, 2020

Abstract

Proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors are a novel class of non-statin lipid lowering therapy that reduce LDL-cholesterol by 50 - 60%. PCSK9 inhibitors decrease LDL-cholesterol by preventing intracellular degradation of LDL receptors; subsequently, a greater number of LDL-receptors are available on the cell surface to extract circulating LDL.
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DOI
10.2174/1871530320666200213114138
pmid
32053090

Abstract

Proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors are a novel class of non-statin lipid lowering therapy that reduce LDL-cholesterol by 50 - 60%. PCSK9 inhibitors decrease LDL-cholesterol by preventing intracellular degradation of LDL receptors; subsequently, a greater number of LDL-receptors are available on the cell surface to extract circulating LDL.

Journal

Endocrine, metabolic & immune disorders drug targetsPubmed

Published: Feb 13, 2020

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