Molecular Imaging and In Situ Quantitative Profiling of Fatty Acid Synthase with a Chemical Probe.

Molecular Imaging and In Situ Quantitative Profiling of Fatty Acid Synthase with a Chemical Probe. Cancer cells rely on fatty acid synthase (FASN), a key enzyme for de novo biosynthesis of long chain fatty acids, to sustain their proliferative potential and drive invasion. Unfortunately, conventional FASN assays are technically inadequate for discerning otherwise elusive FASN activity in complex biological milieux, which has hindered progress in the functional study of FASN and development of its inhibitors. Here, we describe a chemical probe with unprecedented selectivity and sensitivity for the labeling of active FASN in living cells, thus demonstrating a new analytical modality for visualizing endogenous FASN activity and exploring opportunities for drug discovery. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Analytical chemistry Pubmed

Molecular Imaging and In Situ Quantitative Profiling of Fatty Acid Synthase with a Chemical Probe.

Analytical chemistry, Volume 92 (6): 8 – Mar 17, 2020
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Molecular Imaging and In Situ Quantitative Profiling of Fatty Acid Synthase with a Chemical Probe.

Analytical chemistry, Volume 92 (6): 8 – Mar 17, 2020

Abstract

Cancer cells rely on fatty acid synthase (FASN), a key enzyme for de novo biosynthesis of long chain fatty acids, to sustain their proliferative potential and drive invasion. Unfortunately, conventional FASN assays are technically inadequate for discerning otherwise elusive FASN activity in complex biological milieux, which has hindered progress in the functional study of FASN and development of its inhibitors. Here, we describe a chemical probe with unprecedented selectivity and sensitivity for the labeling of active FASN in living cells, thus demonstrating a new analytical modality for visualizing endogenous FASN activity and exploring opportunities for drug discovery.
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DOI
10.1021/acs.analchem.9b05327
pmid
32053360

Abstract

Cancer cells rely on fatty acid synthase (FASN), a key enzyme for de novo biosynthesis of long chain fatty acids, to sustain their proliferative potential and drive invasion. Unfortunately, conventional FASN assays are technically inadequate for discerning otherwise elusive FASN activity in complex biological milieux, which has hindered progress in the functional study of FASN and development of its inhibitors. Here, we describe a chemical probe with unprecedented selectivity and sensitivity for the labeling of active FASN in living cells, thus demonstrating a new analytical modality for visualizing endogenous FASN activity and exploring opportunities for drug discovery.

Journal

Analytical chemistryPubmed

Published: Mar 17, 2020

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