Iron Hydride Radical Reductive Alkylation of Unactivated Alkenes.

Iron Hydride Radical Reductive Alkylation of Unactivated Alkenes. Iron-catalyzed hydrogen atom transfer-mediated intermolecular C-C coupling reactions between alkenes and tosylhydrazones, followed by in situ cleavage of the tosylhydrazine intermediates using Et3N, are described. The process involves a new strategic bond disconnection resulting in the reductive alkylation of nonactivated alkenes. The reaction is operationally simple, proceeds under mild conditions, and has a wide substrate scope. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Organic letters Pubmed

Iron Hydride Radical Reductive Alkylation of Unactivated Alkenes.

Organic letters, Volume 22 (2): 5 – Mar 4, 2020
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Iron Hydride Radical Reductive Alkylation of Unactivated Alkenes.

Organic letters, Volume 22 (2): 5 – Mar 4, 2020

Abstract

Iron-catalyzed hydrogen atom transfer-mediated intermolecular C-C coupling reactions between alkenes and tosylhydrazones, followed by in situ cleavage of the tosylhydrazine intermediates using Et3N, are described. The process involves a new strategic bond disconnection resulting in the reductive alkylation of nonactivated alkenes. The reaction is operationally simple, proceeds under mild conditions, and has a wide substrate scope.
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DOI
10.1021/acs.orglett.9b04459
pmid
31887044

Abstract

Iron-catalyzed hydrogen atom transfer-mediated intermolecular C-C coupling reactions between alkenes and tosylhydrazones, followed by in situ cleavage of the tosylhydrazine intermediates using Et3N, are described. The process involves a new strategic bond disconnection resulting in the reductive alkylation of nonactivated alkenes. The reaction is operationally simple, proceeds under mild conditions, and has a wide substrate scope.

Journal

Organic lettersPubmed

Published: Mar 4, 2020

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