Identification of Dual negative allosteric modulators of Group I mGluR family: A shape based screening, ADME Prediction, Induced Fit Docking and Molecular Dynamics approach against Neurodegenerative Diseases.

Identification of Dual negative allosteric modulators of Group I mGluR family: A shape based... Glutamate is principal neurotransmitter in human brain that exerts its effects through iGlu and mGlu receptors. The mGluRs are the class C GPCRs play vital role in various neurobiological functions, mGluR1 and mGluR5 are the two receptors distributed throughout the brain involved in cognition, learning, memory and other important neurological process. Dysfunction of these receptors can cause neurodegenerative diseases such as Alzheimer's disease, Parkinson Disease, X-fragile syndrome, anxiety, depression etc., hence these receptors are high profile targets for pharmaceutical industries. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current topics in medicinal chemistry Pubmed

Identification of Dual negative allosteric modulators of Group I mGluR family: A shape based screening, ADME Prediction, Induced Fit Docking and Molecular Dynamics approach against Neurodegenerative Diseases.

Current topics in medicinal chemistry: 1 – Nov 8, 2019
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Identification of Dual negative allosteric modulators of Group I mGluR family: A shape based screening, ADME Prediction, Induced Fit Docking and Molecular Dynamics approach against Neurodegenerative Diseases.

Current topics in medicinal chemistry: 1 – Nov 8, 2019

Abstract

Glutamate is principal neurotransmitter in human brain that exerts its effects through iGlu and mGlu receptors. The mGluRs are the class C GPCRs play vital role in various neurobiological functions, mGluR1 and mGluR5 are the two receptors distributed throughout the brain involved in cognition, learning, memory and other important neurological process. Dysfunction of these receptors can cause neurodegenerative diseases such as Alzheimer's disease, Parkinson Disease, X-fragile syndrome, anxiety, depression etc., hence these receptors are high profile targets for pharmaceutical industries.
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DOI
10.2174/1568026619666191105112800

Abstract

Glutamate is principal neurotransmitter in human brain that exerts its effects through iGlu and mGlu receptors. The mGluRs are the class C GPCRs play vital role in various neurobiological functions, mGluR1 and mGluR5 are the two receptors distributed throughout the brain involved in cognition, learning, memory and other important neurological process. Dysfunction of these receptors can cause neurodegenerative diseases such as Alzheimer's disease, Parkinson Disease, X-fragile syndrome, anxiety, depression etc., hence these receptors are high profile targets for pharmaceutical industries.

Journal

Current topics in medicinal chemistryPubmed

Published: Nov 8, 2019

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