The green synthesis of nanomaterials has emerged as a sustainable and environmentally friendly approach, gaining significant attention in recent years for its potential in a wide range of multifunctional applications. Among these materials, zinc oxide nanoparticles (ZnO NPs) stand out due to their remarkable versatility and effectiveness in fields such as industry (food, chemistry, and cosmetics), nanomedicine, cancer therapy, drug delivery, optoelectronics, sensors, and environmental remediation. This study focuses on bioinspired strategies for the facile synthesis of ZnO NPs, employing natural polysaccharide gums as mediators. Acting as both reducing and stabilizing agents, natural gums not only facilitate the eco-friendly production of ZnO NPs but also enhance their stability and functionality. Natural gum-mediated green synthesis typically yields stable, spherical ZnO particles, often in the 10-100 nm range. Typical reaction conditions are the use of zinc acetate dihydrate or zinc nitrate (0.01-0.5 M) as precursors, with low gum concentrations of 0.1-1.0% (w/v) in distilled water, alkaline conditions (pH from 8 to 12), often achieved by adding NaOH, which aids in the reduction and capping by the gum, at reaction temperature between 60 °C and 80 °C, under continuous stirring. The dried precipitate is often calcined at 400 °C to 600 °C to remove organic residues and enhance crystallinity. This approach underscores the potential of biopolymer-assisted synthesis in advancing green nanotechnology for sustainable and practical applications. Utilizing environmentally benign materials such as natural gums for the synthesis of ZnO NPs offers significant advantages, including enhanced eco-friendliness and biocompatibility, making them suitable for a wide range of applications without the involvement of toxic reagents. This review provides an in-depth analysis of the synthesis and characterization techniques employed in the eco-friendly production of ZnO NPs using different natural gums from biological sources and its environmental applications (e.g., pollutant removal and increased agriculture sustainability).