Different absorption and metabolism of ginsenosides after administrations of total ginsenosides and decoction of Panax Ginseng.
AbstractPanax Ginseng C.A. Meyer (PG), which has major bioactive components of polysaccharides and ginsenosides, has been used to promote health and treat diseases for thousands of years in China. Total ginsenosides were extracted from a decoction of Panax Ginseng (GD), that included both ginsenosides and polysaccharides, and dissolved in water to obtain a total ginsenosides aqueous solution (TGAS), that contained ginsenosides only. With the aim of exploring their absorption and metabolic, the pharmacokinetics and metabolites of ginsenosides in vivo were investigated after administrations of GD and TGAS.