A base editing resource for functional annotation of DNA repair variants in breast-derived cell models.

Masud, Wardah; Russo, Ludovica; Chapdelaine-Trépanier, Vincent; Hayward, Samuel B; He, Wei; Cirò, Marco; Mercurio, Ciro; Xu, Han; Ciccia, Alberto; Cuella-Martin, Raquel; Leuzzi, Giuseppe

Frontiers in Cell and Developmental BiologyApr 13, 2026

A base editing resource for functional annotation of DNA repair variants in breast-derived cell models.

Abstract

The DNA damage response (DDR) safeguards genome integrity, and its disruption contributes to cancer development, therapy response, and resistance. Large-scale sequencing has identified thousands of DDR gene variants in tumors, but the functional consequences of most remain unclear, limiting their clinical interpretation and application.

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