COMMENTARY meta-analysis of 4 hypertension Launching APOLLO: trials, subjects with 1 or 2 APOL1 The Role of APOL1 Genetic risk alleles and mild to moderate hypertension had a greater fall in Variants in Live- and Deceased-Donor systolic blood pressure with can- desartan (12 vs. 8 mg Hg) and a Kidney Transplantation greater decline in albuminuria (8 1 1 vs. 4 mg/d), compared with those Federico Fuentes and Jeffrey B. Kopp with zero APOL1 risk alleles, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Dis- whereas there were no differences eases, National Institutes of Health, Bethesda, Maryland, USA by genotype for thiazides or beta blockers. Candesartan is a high- Kidney Int Rep (2020) 5, 252–254; https://doi.org/10.1016/j.ekir.2019.12.014 potency angiotensin receptor Published by Elsevier Inc. on behalf of the International Society of Nephrology. This is blocker with a long duration of an open access article under the CC BY-NC-ND license (http://creativecommons.org/ action. It is more effective at blood licenses/by-nc-nd/4.0/). pressure lowering than losartan and comparable to telmisartan and See Clinical Research on Page 278 S1 valsartan. Whether the effect observed in APOL1 risk allele nthis issue of Kidney Interna- To date, there has not been a carriers is a
Kidney International Reports – Pubmed Central
Published: Dec 27, 2019
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