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Manon Winter, V. Cirulli, I. Bruijn, S. Litvinov (2007)
Cadherins are regulated by Ep-CAM via phosphaditylinositol-3 kinaseMolecular and Cellular Biochemistry, 302
B. Harris, Isabel Pereira, E. Parkin (2009)
Targeting ADAM10 to lipid rafts in neuroblastoma SH-SY5Y cells impairs amyloidogenic processing of the amyloid precursor proteinBrain Research, 1296
Anne-Kathleen Rupp, C. Rupp, Sascha Keller, J. Brase, R. Ehehalt, M. Fogel, G. Moldenhauer, F. Marmé, H. Sültmann, P. Altevogt (2011)
Loss of EpCAM expression in breast cancer derived serum exosomes: role of proteolytic cleavage.Gynecologic oncology, 122 2
Sabrina Desbordes, L. Studer (2012)
Adapting human pluripotent stem cells to high-throughput and high-content screeningNature Protocols, 8
Joann Strnad, Amy Hamilton, Lisa Beavers, Gary Gamboa, L. Apelgren, Larry Taber, J. Sportsman, T. Bumol, John Sharp, R. Gadski (1989)
Molecular cloning and characterization of a human adenocarcinoma/epithelial cell surface antigen complementary DNA.Cancer research, 49 2
Peer-Hendrik Kuhn, Huanhuan Wang, B. Dislich, A. Colombo, U. Zeitschel, J. Ellwart, E. Kremmer, S. Roßner, S. Lichtenthaler (2010)
ADAM10 is the physiologically relevant, constitutive α‐secretase of the amyloid precursor protein in primary neuronsThe EMBO Journal, 29
J. Cordy, I. Hussain, C. Dingwall, N. Hooper, A. Turner (2003)
Exclusively targeting beta-secretase to lipid rafts byGPI-anchor addition up-regulates beta-site processing ofthe amyloid precursor protein
J. Cordy, I. Hussain, C. Dingwall, N. Hooper, A. Turner (2003)
Exclusively targeting β-secretase to lipid rafts by GPI-anchor addition up-regulates β-site processing of the amyloid precursor proteinProceedings of the National Academy of Sciences of the United States of America, 100
R. Tuteja (2005)
Type I signal peptidase: an overview.Archives of biochemistry and biophysics, 441 2
H. Neurath, K. Walsh (1976)
Role of proteolytic enzymes in biological regulation (a review).Proceedings of the National Academy of Sciences of the United States of America, 73 11
V. Cirulli, L. Crisá, G. Beattie, M. Mally, A. López, A. Fannon, A. Ptasznik, L. Inverardi, C. Ricordi, T. Deerinck, Mark Ellisman, R. Reisfeld, A. Hayek (1998)
KSA Antigen Ep-CAM Mediates Cell–Cell Adhesion of Pancreatic Epithelial Cells: Morphoregulatory Roles in Pancreatic Islet DevelopmentThe Journal of Cell Biology, 140
Sonya Craig, S. Brady-Kalnay (2011)
Cancer cells cut homophilic cell adhesion molecules and run.Cancer research, 71 2
Michael Brown, Jin Ye, R. Rawson, J. Goldstein (2000)
Regulated Intramembrane Proteolysis A Control Mechanism Conserved from Bacteria to HumansCell, 100
K. Arnold, L. Bordoli, J. Kopp, T. Schwede (2006)
The SWISS-MODEL workspace: a web-based environment for protein structure homology modellingBioinformatics, 22 2
L. Leij, Wijnand Helrich, R. Stein, M. Mattes (1994)
SCLC‐cluster‐2 antibodies detect the pancarcinoma/epithelial glycoprotein EGP‐2International Journal of Cancer, 57
F. Naour, M. André, C. Boucheix, E. Rubinstein (2006)
Membrane microdomains and proteomics: Lessons from tetraspanin microdomains and comparison with lipid raftsPROTEOMICS, 6
H. Kimura, H. Kato, A. Faried, M. Sohda, M. Nakajima, Y. Fukai, T. Miyazaki, N. Masuda, M. Fukuchi, H. Kuwano (2007)
Prognostic significance of EpCAM expression in human esophageal cancer.International journal of oncology, 30 1
C. Patriarca, R. Macchi, Anja Marschner, H. Mellstedt (2012)
Epithelial cell adhesion molecule expression (CD326) in cancer: a short review.Cancer treatment reviews, 38 1
S. Denzel, D. Maetzel, B. Mack, Carola Eggert, Gabriele Bärr, O. Gires (2009)
Initial activation of EpCAM cleavage via cell-to-cell contactBMC Cancer, 9
D. Maetzel, S. Denzel, B. Mack, M. Canis, P. Went, Michaela Benk, C. Kieu, Peer Papior, P. Baeuerle, Markus Munz, O. Gires (2009)
Nuclear signalling by tumour-associated antigen EpCAMNature Cell Biology, 11
J. Chong, D. Speicher (2001)
Determination of Disulfide Bond Assignments andN-Glycosylation Sites of the Human Gastrointestinal Carcinoma Antigen GA733-2 (CO17-1A, EGP, KS1-4, KSA, and Ep-CAM)*The Journal of Biological Chemistry, 276
Sebastian Kuhn, M. Koch, T. Nübel, Markus Ladwein, D. Antolovic, P. Klingbeil, D. Hildebrand, G. Moldenhauer, L. Langbein, W. Franke, J. Weitz, M. Zöller (2007)
A Complex of EpCAM, Claudin-7, CD44 Variant Isoforms, and Tetraspanins Promotes Colorectal Cancer ProgressionMolecular Cancer Research, 5
C. Boer, J. Krieken, Connie Rhijn, S. Litvinov (1999)
Expression of Ep‐CAM in normal, regenerating, metaplastic, and neoplastic liverThe Journal of Pathology, 188
J. Arribas, A. Borroto (2002)
Protein ectodomain shedding.Chemical reviews, 102 12
D. Edwards, M. Handsley, C. Pennington (2008)
The ADAM metalloproteinasesMolecular Aspects of Medicine, 29
David Kim, D. Chivian, Lars Malmström, David Baker (2005)
Automated prediction of domain boundaries in CASP6 targets using Ginzu and RosettaDOMProteins: Structure, 61
Andrew Beel, C. Sanders (2008)
Substrate specificity of γ-secretase and other intramembrane proteasesCellular and Molecular Life Sciences, 65
M. Sundberg, L. Jansson, Johanna Ketolainen, H. Pihlajamäki, R. Suuronen, H. Skottman, J. Inzunza, O. Hovatta, S. Narkilahti (2009)
CD marker expression profiles of human embryonic stem cells and their neural derivatives, determined using flow-cytometric analysis, reveal a novel CD marker for exclusion of pluripotent stem cells.Stem cell research, 2 2
M. Balzar, Manon Winter, C. Boer, S. Litvinov (1999)
The biology of the 17–1A antigen (Ep-CAM)Journal of Molecular Medicine, 77
Ulrike Schnell, J. Kuipers, James Mueller, Anneke Veenstra-Algra, Mamata Sivagnanam, B. Giepmans (2013)
Absence of cell-surface EpCAM in congenital tufting enteropathy.Human molecular genetics, 22 13
M. Mihelič, D. Turk (2007)
Two decades of thyroglobulin type-1 domain research, 388
(2012)
art:e00030 / doi 10.1042/BSR20120128 SUPPLEMENTARY DATA EpCAM proteolysis: new fragments with distinct functions
Jeroen Kilsdonk, L. Kempen, G. Muijen, D. Ruiter, G. Swart (2010)
Soluble adhesion molecules in human cancers: sources and fates.European journal of cell biology, 89 6
J. Hageman, M. Vos, M. Waarde, H. Kampinga (2007)
Comparison of Intra-organellar Chaperone Capacity for Dealing with Stress-induced Protein Unfolding*Journal of Biological Chemistry, 282
R. Ralhan, H. He, A. So, Satyendra Tripathi, Manish Kumar, Md. Hasan, J. Kaur, Lawrence Kashat, C. Macmillan, S. Chauhan, J. Freeman, P. Walfish (2010)
Nuclear and Cytoplasmic Accumulation of Ep-ICD Is Frequently Detected in Human Epithelial CancersPLoS ONE, 5
S. Petsch, O. Gires, D. Rüttinger, S. Denzel, S. Lippold, P. Baeuerle, A. Wolf (2011)
Concentrations of EpCAM ectodomain as found in sera of cancer patients do not significantly impact redirected lysis and T-cell activation by EpCAM/CD3-bispecific BiTE antibody MT110mAbs, 3
Cécile Arduise, Toufik Abache, Lei Li, M. Billard, A. Chabanon, A. Ludwig, P. Mauduit, C. Boucheix, E. Rubinstein, F. Naour (2008)
Tetraspanins Regulate ADAM10-Mediated Cleavage of TNF-α and Epidermal Growth Factor1The Journal of Immunology, 181
M. Yáñez‐Mó, M. Gutiérrez-López, C. Cabañas (2011)
Functional interplay between tetraspanins and proteasesCellular and Molecular Life Sciences, 68
S. Lichtenthaler, C. Haass, H. Steiner (2011)
Regulated intramembrane proteolysis – lessons from amyloid precursor protein processingJournal of Neurochemistry, 117
V. Turk, V. Stoka, O. Vasiljeva, M. Renko, T. Sun, B. Turk, D. Turk (2011)
Cysteine cathepsins: From structure, function and regulation to new frontiers☆Biochimica et Biophysica Acta. Proteins and Proteomics, 1824
A. Bateman, R. Finn, P. Sims, T. Wiedmer, A. Biegert, J. Söding (2008)
Phospholipid scramblases and Tubby-like proteins belong to a new superfamily of membrane tethered transcription factorsBioinformatics, 25
Mamata Sivagnanam, James Mueller, Hane Lee, Zugen Chen, S. Nelson, D. Turner, S. Zlotkin, P. Pencharz, B. Ngan, Ondrej Libiger, N. Schork, J. Lavine, Sharon Taylor, R. Newbury, R. Kolodner, H. Hoffman (2008)
Identification of EpCAM as the gene for congenital tufting enteropathy.Gastroenterology, 135 2
F. Naour, M. André, C. Greco, M. Billard, B. Sordat, J. Emile, F. Lanza, C. Boucheix, E. Rubinstein (2006)
Profiling of the Tetraspanin Web of Human Colon Cancer Cells *SMolecular & Cellular Proteomics, 5
M. Trzpis, P. McLaughlin, L. Leij, M. Harmsen (2007)
Epithelial cell adhesion molecule: more than a carcinoma marker and adhesion molecule.The American journal of pathology, 171 2
Steffen Runz, Sascha Keller, C. Rupp, Alexander Stoeck, Yasmin Issa, D. Koensgen, A. Mustea, J. Sehouli, G. Kristiansen, P. Altevogt (2007)
Malignant ascites-derived exosomes of ovarian carcinoma patients contain CD24 and EpCAM.Gynecologic oncology, 107 3
M. Gutiérrez-López, Á. Gilsanz, M. Yáñez‐Mó, Susana Ovalle, Esther Lafuente, Carmen Domínguez, P. Monk, I. González-Álvaro, F. Sánchez‐Madrid, C. Cabañas (2011)
The sheddase activity of ADAM17/TACE is regulated by the tetraspanin CD9Cellular and Molecular Life Sciences, 68
Alexander Stoeck, Sascha Keller, S. Riedle, M. Sanderson, Steffen Runz, F. Naour, P. Gutwein, A. Ludwig, E. Rubinstein, P. Altevogt (2006)
A role for exosomes in the constitutive and stimulus-induced ectodomain cleavage of L1 and CD44.The Biochemical journal, 393 Pt 3
Bernardina Gun, L. Melchers, M. Ruiters, L. Leij, P. McLaughlin, M. Rots (2010)
EpCAM in carcinogenesis: the good, the bad or the ugly.Carcinogenesis, 31 11
P. Baeuerle, O. Gires (2007)
EpCAM (CD326) finding its role in cancerBritish Journal of Cancer, 96
Ulrike Schnell, F. Dijk, K. Sjollema, B. Giepmans (2012)
Immunolabeling artifacts and the need for live-cell imagingNature Methods, 9
Daosong Xu, C. Sharma, M. Hemler (2009)
Tetraspanin12 regulates ADAM10‐dependent cleavage of amyloid precursor proteinThe FASEB Journal, 23
S. Szala, Monika Froehlich, Maureen Scollon, Y. Kasai, Z. Steplewski, H. Koprowski, A. Linnenbach (1990)
Molecular cloning of cDNA for the carcinoma-associated antigen GA733-2.Proceedings of the National Academy of Sciences of the United States of America, 87 9
R. Ralhan, Jun Cao, Terence Lim, C. Macmillan, J. Freeman, P. Walfish (2010)
EpCAM nuclear localization identifies aggressive Thyroid Cancer and is a marker for poor prognosisBMC Cancer, 10
R. Ehehalt, P. Keller, C. Haass, C. Thiele, K. Simons (2003)
Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid raftsThe Journal of Cell Biology, 160
T. Nomura, N. Katunuma (2005)
Involvement of cathepsins in the invasion, metastasis and proliferation of cancer cells.The journal of medical investigation : JMI, 52 1-2
H. Abe, Motomu Kuroki, T. Imakiire, Y. Yamauchi, H. Yamada, F. Arakawa, Masahide Kuroki (2002)
Preparation of recombinant MK-1/Ep-CAM and establishment of an ELISA system for determining soluble MK-1/Ep-CAM levels in sera of cancer patients.Journal of immunological methods, 270 2
I. Thampoe, J. Ng, K. Lloyd (1988)
Biochemical analysis of a human epithelial surface antigen: differential cell expression and processing.Archives of biochemistry and biophysics, 267 1
Cécile Arduise, Toufik Abache, Lei Li, M. Billard, A. Chabanon, A. Ludwig, P. Mauduit, C. Boucheix, E. Rubinstein, F. Naour (2008)
Tetraspanins regulate ADAM10-mediated cleavage of TNF-alpha and epidermal growth factor.Journal of immunology, 181 10
M. Schön, M. Schön, M. Mattes, R. Stein, L. Weber, S. Alberti, C. Klein (1993)
Biochemical and immunological characterization of the human carcinoma‐associated antigen MH 99/KS 1/4International Journal of Cancer, 55
R. Marhaba, P. Klingbeil, Tobias Nuebel, I. Nazarenko, M. Buechler, M. Zoeller (2008)
CD44 and EpCAM: cancer-initiating cell markers.Current molecular medicine, 8 8
<%@ Language=VBScript %> <% Option Explicit %> Bioscience Reports (2013) 33, e00030 - U. Schnell, J. Kuipers and B.N.G. Giepmans - EpCAM proteolysis <% SectionNo="S6" strYear="2013" strMonth="" strDay="" Arttype="bsrfull" volshort="33" vol="033" Issue="2" fpageshort="" fpage="" lpageshort="" lpage="" ArticleID="e00030" ArticleIDPath="e030" DOI="10.1042/BSR20120128" MSNumber="BSR20120128" FullTitle="EpCAM proteolysis: new fragments with distinct functions?" AuthorText="Ulrike Schnell, Jeroen Kuipers and Ben N. G. Giepmans 1 " Affiliation="Department of Cell Biology, University Medical Center Groningen, University of Groningen, P.O. Box 196, 9700 AD, Groningen, The Netherlands" MedlineID="23409978" doctype="Original Paper" doctypeDisplay="Original Paper" StripTitle="EpCAM proteolysis: new fragments with distinct functions?" ShortTitle="EpCAM proteolysis" ShortAuthorText="U. Schnell, J. Kuipers and B.N.G. Giepmans" CiteAuthorText="Schnell, U., Kuipers, J. and Giepmans, B. N. G." OpenAccess="1" Multimedia="Supplementary data" %> Key words: cell–cell contact, EpCAM, notch-like signalling, regulated intramembrane proteolysis, polypeptides, shedding. Abbreviations used: ADAM, a disintegrin and metalloprotease; APP, amyloid precursor protein; CAM, cell adhesion molecule; CD326, cluster of differentiation 326; CTE, congenital tufting enteropathy; CTF, C-terminal fragment; DAPT, N -[ N -(3,5-difluorophenacetyl)- L -alanyl]-S-phenylglycine t-butyl ester; DMEM, Dulbecco’s modified Eagle’s medium; ECD, extracellular domain; EGFP, enhanced green fluorescent protein; EpCAM, epithelial cell adhesion molecule; EpEX, EpCAM cleaved extracellular domain; EpICD, EpCAM cleaved intracellular domain; ER, endoplasmic reticulum; FCS, foetal calf serum; GFP, green fluorescent protein;
Bioscience Reports – Portland Press
Published: Mar 19, 2013
Keywords: cell-cell contact, EpCAM, notch-like signalling, regulated intramembrane proteolysis, polypeptides, shedding
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