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EpCAM proteolysis: new fragments with distinct functions?

EpCAM proteolysis: new fragments with distinct functions? <%@ Language=VBScript %> <% Option Explicit %> Bioscience Reports (2013) 33, e00030 - U. Schnell, J. Kuipers and B.N.G. Giepmans - EpCAM proteolysis <% SectionNo="S6" strYear="2013" strMonth="" strDay="" Arttype="bsrfull" volshort="33" vol="033" Issue="2" fpageshort="" fpage="" lpageshort="" lpage="" ArticleID="e00030" ArticleIDPath="e030" DOI="10.1042/BSR20120128" MSNumber="BSR20120128" FullTitle="EpCAM proteolysis: new fragments with distinct functions?" AuthorText="Ulrike Schnell, Jeroen Kuipers and Ben N. G. Giepmans 1 " Affiliation="Department of Cell Biology, University Medical Center Groningen, University of Groningen, P.O. Box 196, 9700 AD, Groningen, The Netherlands" MedlineID="23409978" doctype="Original Paper" doctypeDisplay="Original Paper" StripTitle="EpCAM proteolysis: new fragments with distinct functions?" ShortTitle="EpCAM proteolysis" ShortAuthorText="U. Schnell, J. Kuipers and B.N.G. Giepmans" CiteAuthorText="Schnell, U., Kuipers, J. and Giepmans, B. N. G." OpenAccess="1" Multimedia="Supplementary data" %> Key words: cell–cell contact, EpCAM, notch-like signalling, regulated intramembrane proteolysis, polypeptides, shedding. Abbreviations used: ADAM, a disintegrin and metalloprotease; APP, amyloid precursor protein; CAM, cell adhesion molecule; CD326, cluster of differentiation 326; CTE, congenital tufting enteropathy; CTF, C-terminal fragment; DAPT, N -[ N -(3,5-difluorophenacetyl)- L -alanyl]-S-phenylglycine t-butyl ester; DMEM, Dulbecco’s modified Eagle’s medium; ECD, extracellular domain; EGFP, enhanced green fluorescent protein; EpCAM, epithelial cell adhesion molecule; EpEX, EpCAM cleaved extracellular domain; EpICD, EpCAM cleaved intracellular domain; ER, endoplasmic reticulum; FCS, foetal calf serum; GFP, green fluorescent protein; http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Bioscience Reports Portland Press

EpCAM proteolysis: new fragments with distinct functions?

Bioscience Reports , Volume 33 – Mar 19, 2013
14 pages

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References (60)

Publisher
Portland Press
Copyright
Copyright by Portland Press
ISSN
0144-8463
eISSN
1573-4935
DOI
10.1042/BSR20120128
pmid
23409978
Publisher site
See Article on Publisher Site

Abstract

<%@ Language=VBScript %> <% Option Explicit %> Bioscience Reports (2013) 33, e00030 - U. Schnell, J. Kuipers and B.N.G. Giepmans - EpCAM proteolysis <% SectionNo="S6" strYear="2013" strMonth="" strDay="" Arttype="bsrfull" volshort="33" vol="033" Issue="2" fpageshort="" fpage="" lpageshort="" lpage="" ArticleID="e00030" ArticleIDPath="e030" DOI="10.1042/BSR20120128" MSNumber="BSR20120128" FullTitle="EpCAM proteolysis: new fragments with distinct functions?" AuthorText="Ulrike Schnell, Jeroen Kuipers and Ben N. G. Giepmans 1 " Affiliation="Department of Cell Biology, University Medical Center Groningen, University of Groningen, P.O. Box 196, 9700 AD, Groningen, The Netherlands" MedlineID="23409978" doctype="Original Paper" doctypeDisplay="Original Paper" StripTitle="EpCAM proteolysis: new fragments with distinct functions?" ShortTitle="EpCAM proteolysis" ShortAuthorText="U. Schnell, J. Kuipers and B.N.G. Giepmans" CiteAuthorText="Schnell, U., Kuipers, J. and Giepmans, B. N. G." OpenAccess="1" Multimedia="Supplementary data" %> Key words: cell–cell contact, EpCAM, notch-like signalling, regulated intramembrane proteolysis, polypeptides, shedding. Abbreviations used: ADAM, a disintegrin and metalloprotease; APP, amyloid precursor protein; CAM, cell adhesion molecule; CD326, cluster of differentiation 326; CTE, congenital tufting enteropathy; CTF, C-terminal fragment; DAPT, N -[ N -(3,5-difluorophenacetyl)- L -alanyl]-S-phenylglycine t-butyl ester; DMEM, Dulbecco’s modified Eagle’s medium; ECD, extracellular domain; EGFP, enhanced green fluorescent protein; EpCAM, epithelial cell adhesion molecule; EpEX, EpCAM cleaved extracellular domain; EpICD, EpCAM cleaved intracellular domain; ER, endoplasmic reticulum; FCS, foetal calf serum; GFP, green fluorescent protein;

Journal

Bioscience ReportsPortland Press

Published: Mar 19, 2013

Keywords: cell-cell contact, EpCAM, notch-like signalling, regulated intramembrane proteolysis, polypeptides, shedding

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