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Opioid activity of a peptide, beta-lipotropin-(61-91), derived from beta-lipotropin

Opioid activity of a peptide, beta-lipotropin-(61-91), derived from beta-lipotropin The pituitary peptide beta-lipotropin displays essentially no opoid activity in a preparation of guinea pig ileum or in the opiate receptor binding assay. However, a fragment, beta-lipotropin-(61-91), with the enkephalin sequence (Tyr-Gly-Gly-Phe-Met) at its NH2-terminus, has typical opioid effects in these two assays. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Proceedings of the National Academy of Sciences PNAS

Opioid activity of a peptide, beta-lipotropin-(61-91), derived from beta-lipotropin

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Opioid activity of a peptide, beta-lipotropin-(61-91), derived from beta-lipotropin

Cox, B M; Goldstein, A; Hi, C H
Proceedings of the National Academy of Sciences , Volume 73 (6): 1821 – Jun 1, 1976

Abstract

The pituitary peptide beta-lipotropin displays essentially no opoid activity in a preparation of guinea pig ileum or in the opiate receptor binding assay. However, a fragment, beta-lipotropin-(61-91), with the enkephalin sequence (Tyr-Gly-Gly-Phe-Met) at its NH2-terminus, has typical opioid effects in these two assays.

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Publisher
PNAS
Copyright
Copyright ©2009 by the National Academy of Sciences
ISSN
0027-8424
eISSN
1091-6490
Publisher site
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Abstract

The pituitary peptide beta-lipotropin displays essentially no opoid activity in a preparation of guinea pig ileum or in the opiate receptor binding assay. However, a fragment, beta-lipotropin-(61-91), with the enkephalin sequence (Tyr-Gly-Gly-Phe-Met) at its NH2-terminus, has typical opioid effects in these two assays.

Journal

Proceedings of the National Academy of Sciences – PNAS

Published: Jun 1, 1976

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