Access the full text.
Sign up today, get DeepDyve free for 14 days.
File Description: Published version License: CC BY-NC-ND
(2018)
herd protection or herd peril? Chest 2014; 146:890–8
J. Hurley (2018)
Unusually High Incidences of Staphylococcus aureus Infection within Studies of Ventilator Associated Pneumonia Prevention Using Topical Antibiotics: Benchmarking the Evidence BaseMicroorganisms, 6
J. Hurley (2015)
ICU-acquired candidemia within selective digestive decontamination studies: a meta-analysisIntensive Care Medicine, 41
M. Lambert, C. Suetens, A. Savey, M. Palomar, M. Hiesmayr, I. Morales, A. Agodi, U. Frank, K. Mertens, M. Schumacher, M. Wolkewitz (2011)
Clinical outcomes of health-care-associated infections and antimicrobial resistance in patients admitted to European intensive-care units: a cohort study.The Lancet. Infectious diseases, 11 1
J. Hurley (2008)
Profound effect of study design factors on ventilator-associated pneumonia incidence of prevention studies: benchmarking the literature experience.The Journal of antimicrobial chemotherapy, 61 5
C. Verwaest, J. Verhaegen, P. Ferdinande, M. Schetz, G. Berghe, L. Verbist, P. Lauwers (1997)
Randomized, controlled trial of selective digestive decontamination in 600 mechanically ventilated patients in a multidisciplinary intensive care unit.Critical care medicine, 25 1
C. Brun-Buisson, P. Legrand, A. Rauss, C. Richard, F. Montravers, M. Besbes, J. Meakins, C. Soussy, F. Lemaire (1989)
Intestinal decontamination for control of nosocomial multiresistant gram-negative bacilli. Study of an outbreak in an intensive care unit.Annals of internal medicine, 110 11
James Hurley (2018)
Paradoxical Acinetobacter-associated ventilator-associated pneumonia incidence rates within prevention studies using respiratory tract applications of topical polymyxin: benchmarking the evidence base.The Journal of hospital infection, 100 1
(2002)
Hurley ICU patients colonized by multi-resistant Acinetobacter baumannii
J. Hurley (1995)
Prophylaxis with enteral antibiotics in ventilated patients: selective decontamination or selective cross-infection?Antimicrobial Agents and Chemotherapy, 39
J. Hurley (2014)
Ventilator-associated pneumonia prevention methods using topical antibiotics: herd protection or herd peril?Chest, 146 4
A. Smet, J. Kluytmans, B. Cooper, E. Mascini, R. Benus, T. Werf, J. Hoeven, P. Pickkers, D. Bogaers-Hofman, N. Meer, A. Bernards, E. Kuijper, J. Joore, M. Hall, A. Bindels, A. Jansz, R. Wesselink, B. Jongh, P. Dennesen, G. Asselt, L. Velde, I. Frénay, K. Kaasjager, F. Bosch, M. Iterson, S. Thijsen, G. Kluge, W. Pauw, J. Vries, J. Kaan, J. Arends, L. Aarts, P. Sturm, H. Harinck, A. Voss, E. Uijtendaal, H. Blok, E. Groen, M. Pouw, C. Kalkman, M. Bonten (2009)
Decontamination of the digestive tract and oropharynx in ICU patients.The New England journal of medicine, 360 1
L. Silvestri, W. Weir, D. Gregori, N. Taylor, D. Zandstra, J. Saene, H. Saene (2017)
Impact of Oral Chlorhexidine on Bloodstream Infection in Critically Ill Patients: Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of cardiothoracic and vascular anesthesia, 31 6
J. Hurley (2005)
Inapparent Outbreaks of Ventilator-Associated Pneumonia An Ecologic Analysis of Prevention and Cohort StudiesInfection Control & Hospital Epidemiology, 26
M. Kollef, J. Chastre, J. Fagon, B. François, M. Niederman, J. Rello, A. Torres, J. Vincent, R. Wunderink, K. Go, C. Rehm (2014)
Global Prospective Epidemiologic and Surveillance Study of Ventilator-Associated Pneumonia due to Pseudomonas aeruginosa*Critical Care Medicine, 42
W. Alhazzani, O. Smith, J. Muscedere, James Medd, D. Cook (2013)
Toothbrushing for Critically Ill Mechanically Ventilated Patients: A Systematic Review and Meta-Analysis of Randomized Trials Evaluating Ventilator-Associated Pneumonia*Critical Care Medicine, 41
L. Silvestri, H. Saene, A. Casarin, G. Berlot, A. Gullo (2008)
Impact of Selective Decontamination of the Digestive Tract on Carriage and Infection Due to Gram-Negative and Gram-Positive Bacteria: A Systematic Review of Randomised Controlled TrialsAnaesthesia and Intensive Care, 36
J. Hurley (2011)
Paradoxical ventilator associated pneumonia incidences among selective digestive decontamination studies versus other studies of mechanically ventilated patients: benchmarking the evidence baseCritical Care, 15
R. D'amico, Silvia eri, V. Torri, L. Brazzi, E. Parmelli, A. Liberati (2004)
Antibiotic prophylaxis to reduce respiratory tract infections and mortality in adults receiving intensive care.The Cochrane database of systematic reviews, 1
C. Lübbert, S. Faucheux, D. Becker-Rux, S. Laudi, A. Dürrbeck, T. Busch, P. Gastmeier, T. Eckmanns, A. Rodloff, U. Kaisers (2013)
Rapid emergence of secondary resistance to gentamicin and colistin following selective digestive decontamination in patients with KPC-2-producing Klebsiella pneumoniae: a single-centre experience.International journal of antimicrobial agents, 42 6
J. Hurley (2018)
Incidences of Pseudomonas aeruginosa-Associated Ventilator-Associated Pneumonia within Studies of Respiratory Tract Applications of Polymyxin: Testing the Stoutenbeek Concurrency PostulatesAntimicrobial Agents and Chemotherapy, 62
S. Labeau, Katrien Vyver, N. Brusselaers, D. Vogelaers, S. Blot (2011)
Prevention of ventilator-associated pneumonia with oral antiseptics: a systematic review and meta-analysis.The Lancet. Infectious diseases, 11 11
L. Saidel-Odes, H. Polachek, N. Peled, K. Riesenberg, F. Schlaeffer, Y. Trabelsi, S. Eskira, B. Yousef, Rozalia Smolykov, S. Codish, A. Borer (2012)
A Randomized, Double-Blind, Placebo-Controlled Trial of Selective Digestive Decontamination Using Oral Gentamicin and Oral Polymyxin E for Eradication of Carbapenem-Resistant Klebsiella pneumoniae CarriageInfection Control & Hospital Epidemiology, 33
R. Brown, D. Phillips, M. Barker, R. Pieczarka, M. Sands, D. Teres (1989)
Outbreak of nosocomial Flavobacterium meningosepticum respiratory infections associated with use of aerosolized polymyxin B.American journal of infection control, 17 3
Ross Harris, J. Deeks, D. Altman, M. Bradburn, R. Harbord, J. Sterne (2008)
Metan: Fixed- and Random-Effects Meta-AnalysisThe Stata Journal, 8
Unusually High Incidences of Pseudomonas Bacteremias Within Topical Polymyxin-Based Decolonization Studies of Mechanically Ventilated Patients: Benchmarking the Literature Date
J. Hurley (2014)
Topical antibiotics as a major contextual hazard toward bacteremia within selective digestive decontamination studies: a meta-analysisBMC Infectious Diseases, 14
C. Agustí, M. Pujol, M. Argerich, J. Ayats, M. Badia, M. Domínguez, X. Corbella, J. Ariza (2002)
Short-term effect of the application of selective decontamination of the digestive tract on different body site reservoir ICU patients colonized by multi-resistant Acinetobacter baumannii.The Journal of antimicrobial chemotherapy, 49 1
R. Harbord, J. Higgins (2008)
Meta-Regression in StataThe Stata Journal, 8
L. Silvestri, H. Saene, M. Milanese, Dario Gregori, A. Gullo (2007)
Selective decontamination of the digestive tract reduces bacterial bloodstream infection and mortality in critically ill patients. Systematic review of randomized, controlled trials.The Journal of hospital infection, 65 3
T. Halaby, N. Naiemi, J. Kluytmans, J. Palen, C. Vandenbroucke-Grauls (2013)
Emergence of Colistin Resistance in Enterobacteriaceae after the Introduction of Selective Digestive Tract Decontamination in an Intensive Care UnitAntimicrobial Agents and Chemotherapy, 57
C. Pileggi, A. Bianco, Domenico Flotta, C. Nobile, M. Pavia (2011)
Prevention of ventilator-associated pneumonia, mortality and all intensive care unit acquired infections by topically applied antimicrobial or antiseptic agents: a meta-analysis of randomized controlled trials in intensive care unitsCritical Care, 15
J. Hurley (2016)
Impact of selective digestive decontamination on respiratory tract Candida among patients with suspected ventilator-associated pneumonia. A meta-analysisEuropean Journal of Clinical Microbiology & Infectious Diseases, 35
M. Klompas, Kathleen Speck, M. Howell, L. Greene, S. Berenholtz (2014)
Reappraisal of routine oral care with chlorhexidine gluconate for patients receiving mechanical ventilation: systematic review and meta-analysis.JAMA internal medicine, 174 5
BackgroundTopical polymyxin (PM)–based regimens to decolonize patients receiving prolonged mechanical ventilation (MV) have been widely studied. However, paradoxical bacteremia incidences remain unexplained.MethodsThe literature was searched for studies of topical PM–based regimens used to decontaminate MV patients reporting incidences of overall and Pseudomonas bacteremia data. In addition, observational groups without any intervention and trials of various interventions other than topical PM (non-PM studies) served to provide external benchmarks and additional points of reference, respectively. The bacteremia incidences were extracted from the control and intervention (component) groups of these studies and compared with metaregression using generalized estimating equation methods.ResultsThe summary odds ratio derived from studies of topical PM–based interventions against overall bacteremia was 0.60 (95% confidence interval [CI], 0.53–0.69). Benchmark incidences per 100 MV patients for overall (mean, 8.9%; 95% CI, 6.9% to 10.9%) and Pseudomonas (mean, 0.7%; 95% CI, 0.5% to 1.1%) bacteremia were derived from 16 observational studies. By contrast, among 17 studies of topical PM, the mean incidences among control groups for overall (mean, 15.3%; 95% CI, 11.5% to 20.3%) and Pseudomonas (mean, 1.6%; 95% CI, 0.9% to 3.1%) bacteremia were both higher, whereas these incidences in the intervention groups for both topical PM and non-PM studies were in each case more similar to the respective benchmarks. These paradoxical incidences cannot readily be explained in metaregression models.ConclusionsParadoxically, despite an apparent prevention effect of topical PM–based methods against bacteremia overall, the incidences of Pseudomonas bacteremia within the component groups of these studies are unusually high vs literature-derived benchmarks.
Open Forum Infectious Diseases – Oxford University Press
Published: Oct 10, 2018
Keywords: bacteremia; intensive care; Pseudomonas; polymyxin; selective digestive decontamination
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.