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The Influence of Age on the 24-Hour Integrated Concentration of Growth Hormone in Normal Individuals

The Influence of Age on the 24-Hour Integrated Concentration of Growth Hormone in Normal Individuals Abstract We examined changes in spontaneously secreted growth hormone with aging by studying the 24-h integrated concentration of GH (IC-GH) of 173 nonobese subjects (height, ≥5%; 7–65 yr of age). There was no significant difference in IC-GH on repeat testing of 13 men or in 23 women studied in the follicular and again in the luteal phase of the menstrual cycle. The level of IC-GH was strongly effected by age; children had the highest mean IC-GH, and there was a decline in IC-GH with increasing age after the second decade of life. The correlation of IC-GH with age was highly significant (r = 0.73; P < 0.0001). There was no difference in IC-GH between males and females when matched for age. The mean IC-GH at Tanner stage 5 of puberty (7.4 ± 2.0 ng/ml) was higher than that at stages 2–4 (5.7 ± 1.4; P < 0.0005) or that irl prepubertal children (5.8 ± 1.4; P < 0.001). Thus, age and pubertal status must be carefully considered when interpreting the IC-GH for patients suspected of having deficient or excessive secretion of GH. This content is only available as a PDF. Author notes * This work was supported by Research Grant HD-16077 from the NIH, USPHS. The patients were studied at the Clinical Research Center of Pediatrics, Johns Hopkins Hospital, supported by Grant RR-0052 from the General Clinical Research Centers Program of the Division of Research Resources, NIH. † t Supported in part by grants from the Meyerhoff and Strauss Foundations. Current address: Kaplan Hospital, Rehovot, Israel. Copyright © 1985 by The Endocrine Society http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Clinical Endocrinology and Metabolism Oxford University Press

The Influence of Age on the 24-Hour Integrated Concentration of Growth Hormone in Normal Individuals

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References (23)

Publisher
Oxford University Press
Copyright
Copyright © 1985 by The Endocrine Society
ISSN
0021-972X
eISSN
1945-7197
DOI
10.1210/jcem-60-3-513
Publisher site
See Article on Publisher Site

Abstract

Abstract We examined changes in spontaneously secreted growth hormone with aging by studying the 24-h integrated concentration of GH (IC-GH) of 173 nonobese subjects (height, ≥5%; 7–65 yr of age). There was no significant difference in IC-GH on repeat testing of 13 men or in 23 women studied in the follicular and again in the luteal phase of the menstrual cycle. The level of IC-GH was strongly effected by age; children had the highest mean IC-GH, and there was a decline in IC-GH with increasing age after the second decade of life. The correlation of IC-GH with age was highly significant (r = 0.73; P < 0.0001). There was no difference in IC-GH between males and females when matched for age. The mean IC-GH at Tanner stage 5 of puberty (7.4 ± 2.0 ng/ml) was higher than that at stages 2–4 (5.7 ± 1.4; P < 0.0005) or that irl prepubertal children (5.8 ± 1.4; P < 0.001). Thus, age and pubertal status must be carefully considered when interpreting the IC-GH for patients suspected of having deficient or excessive secretion of GH. This content is only available as a PDF. Author notes * This work was supported by Research Grant HD-16077 from the NIH, USPHS. The patients were studied at the Clinical Research Center of Pediatrics, Johns Hopkins Hospital, supported by Grant RR-0052 from the General Clinical Research Centers Program of the Division of Research Resources, NIH. † t Supported in part by grants from the Meyerhoff and Strauss Foundations. Current address: Kaplan Hospital, Rehovot, Israel. Copyright © 1985 by The Endocrine Society

Journal

Journal of Clinical Endocrinology and Metabolism – Oxford University Press

Published: Mar 1, 1985

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