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The Hancock pericardial xenograft: incidence of early mechanical failures at a medium-term follow-up

The Hancock pericardial xenograft: incidence of early mechanical failures at a medium-term follow-up AbstractThe Hancock pericardial xenograft has been used in our Institution sinceAugust 1981 as an alternative to porcine bioprostheses. Up to July 1984, 97Hancock pericardial xenografts have been implanted in 84 patients; of 76operative survivors with a mean age of 55.2 +/- 13 years (range 13-75years), 50 had undergone aortic valve replacement, 16 mitral valvereplacement and 10 mitral-aortic valve replacement. Follow-up ranged from0.5 to 5.2 years with a cumulative duration of 239 patient/years and is 99%complete. Actuarial survival is 92% +/- 4% for patients with aortic valvereplacement and 84% +/- 10% for patients with mitral valve replacement at 5years, and 77% +/- 14% for those with mitral-aortic valve replacement at 4years. Thromboembolic episodes occurred in 2 patients (1 after aortic and 1after mitral valve replacement). The actuarial freedom from emboli is 100%for patients with mitral-aortic valve replacement at 4 years, and 96% +/-3% for patients with aortic and 93% +/- 6% for patients with mitral valvereplacement at 5 years. Reoperation was performed in 13 patients (9 aortic,2 mitral and 2 mitral-aortic valve replacements), because of endocarditisin 3 (2 aortic and 1 mitral valve replacement), paravalvular leak in 1(aortic valve replacement), and primary tissue failure in 9 (6 aortic, 1mitral and 2 mitral-aortic valve replacements). Actuarial freedom fromprimary tissue failure is 72% +/- 9% for aortic and 83% +/- 8% for mitralHancock pericardial xenografts at 5 years. Eleven xenografts explantedbecause of primary tissue failure were studied pathologically.(ABSTRACTTRUNCATED AT 250 WORDS) http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Cardio-Thoracic Surgery Oxford University Press

The Hancock pericardial xenograft: incidence of early mechanical failures at a medium-term follow-up

European Journal of Cardio-Thoracic Surgery , Volume 2 (6) – Nov 1, 1988

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References (18)

Publisher
Oxford University Press
Copyright
© Springer-Verlag 1988
ISSN
1010-7940
eISSN
1873-734X
DOI
10.1016/1010-7940(88)90052-8
Publisher site
See Article on Publisher Site

Abstract

AbstractThe Hancock pericardial xenograft has been used in our Institution sinceAugust 1981 as an alternative to porcine bioprostheses. Up to July 1984, 97Hancock pericardial xenografts have been implanted in 84 patients; of 76operative survivors with a mean age of 55.2 +/- 13 years (range 13-75years), 50 had undergone aortic valve replacement, 16 mitral valvereplacement and 10 mitral-aortic valve replacement. Follow-up ranged from0.5 to 5.2 years with a cumulative duration of 239 patient/years and is 99%complete. Actuarial survival is 92% +/- 4% for patients with aortic valvereplacement and 84% +/- 10% for patients with mitral valve replacement at 5years, and 77% +/- 14% for those with mitral-aortic valve replacement at 4years. Thromboembolic episodes occurred in 2 patients (1 after aortic and 1after mitral valve replacement). The actuarial freedom from emboli is 100%for patients with mitral-aortic valve replacement at 4 years, and 96% +/-3% for patients with aortic and 93% +/- 6% for patients with mitral valvereplacement at 5 years. Reoperation was performed in 13 patients (9 aortic,2 mitral and 2 mitral-aortic valve replacements), because of endocarditisin 3 (2 aortic and 1 mitral valve replacement), paravalvular leak in 1(aortic valve replacement), and primary tissue failure in 9 (6 aortic, 1mitral and 2 mitral-aortic valve replacements). Actuarial freedom fromprimary tissue failure is 72% +/- 9% for aortic and 83% +/- 8% for mitralHancock pericardial xenografts at 5 years. Eleven xenografts explantedbecause of primary tissue failure were studied pathologically.(ABSTRACTTRUNCATED AT 250 WORDS)

Journal

European Journal of Cardio-Thoracic SurgeryOxford University Press

Published: Nov 1, 1988

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