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Moumita Roy, S. Sen, A. Chakraborti (2008)
Action of pelargonidin on hyperglycemia and oxidative damage in diabetic rats: implication for glycation-induced hemoglobin modification.Life sciences, 82 21-22
G. Jensen, Xianli Wu, K. Patterson, J. Barnes, Steve Carter, Larry Scherwitz, Robert Beaman, J. Endres, A. Schauss (2008)
In vitro and in vivo antioxidant and anti-inflammatory capacities of an antioxidant-rich fruit and berry juice blend. Results of a pilot and randomized, double-blinded, placebo-controlled, crossover study.Journal of agricultural and food chemistry, 56 18
C. Williams, Manal Mohsen, Dr Vauzour, Catarina Rendeiro, L. Butler, J. Ellis, M. Whiteman, J. Spencer (2008)
Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels.Free radical biology & medicine, 45 3
S. Coster, D. Leeuwen, D. Jennen, G. Koppen, E. Hond, V. Nelen, G. Schoeters, W. Baeyens, J. Delft, J. Kleinjans, N. Larebeke (2013)
Gender‐specific transcriptomic response to environmental exposure in flemish adultsEnvironmental and Molecular Mutagenesis, 54
Gary Stoner, Li‐Shu Wang, C. Seguin, Claudio Rocha, K. Stoner, S. Chiu, A. Kinghorn (2010)
Multiple Berry Types Prevent N-nitrosomethylbenzylamine-Induced Esophageal Cancer in RatsPharmaceutical Research, 27
S. Zafra-Stone, T. Yasmin, M. Bagchi, A. Chatterjee, J. Vinson, D. Bagchi (2007)
Berry anthocyanins as novel antioxidants in human health and disease prevention.Molecular nutrition & food research, 51 6
Jui-Ching Chen, F. Ho, P. Chao, Chih-Ping Chen, K. Jeng, H. Hsu, Sho‐Tone Lee, Wen-Tung Wu, Wan-Wan Lin (2005)
Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of IkappaB kinase, nuclear factor-kappa B and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia.European journal of pharmacology, 521 1-3
Indika Edirisingheb, Jody Randolphc, Francene Steinbergc, Tissa Kappagodaa (2008)
Mechanism of the endothelium-dependent relaxation evoked by a grape seed extract.Clinical science, 114 4
D. Hebels, D. Jennen, M. Herwijnen, E. Moonen, M. Pedersen, L. Knudsen, J. Kleinjans, T. Kok (2011)
Whole-genome gene expression modifications associated with nitrosamine exposure and micronucleus frequency in human blood cells.Mutagenesis, 26 6
M. Ndiaye, M. Chataigneau, I. Lobysheva, T. Chataigneau, V. Schini-Kerth (2005)
Red wine polyphenols‐induced, endothelium‐dependent NO‐mediated relaxation is due to the redox‐sensitive PI3‐kinase/Akt‐dependent phosphorylation of endothelial NO‐synthase in the isolated porcine coronary arteryThe FASEB Journal, 19
I. Edirisinghe, B. Burton-Freeman, P. Varelis, T. Kappagoda (2008)
Strawberry extract caused endothelium-dependent relaxation through the activation of PI3 kinase/Akt.Journal of agricultural and food chemistry, 56 20
P. Pignatelli, S. Santo, B. Buchetti, V. Sanguigni, A. Brunelli, E. Violi (2006)
Polyphenols enhance platelet nitric oxide by inhibiting protein kinase C‐dependent NADPH oxidase activation: effect on platelet recruitmentThe FASEB Journal, 20
S. Breda, L. Wilms, S. Gaj, D. Jennen, J. Briedé, Johannes Helsper, J.C.S. Kleinjans, T. Kok (2014)
Can transcriptomics provide insight into the chemopreventive mechanisms of complex mixtures of phytochemicals in humans?Antioxidants & redox signaling, 20 14
J. Moskaug, G. Borge, A. Fagervoll, I. Paur, H. Carlsen, R. Blomhoff (2008)
Dietary polyphenols identified as intracellular protein kinase A inhibitorsEuropean Journal of Nutrition, 47
A. Stull, Katherine Cash, W. Johnson, C. Champagne, W. Cefalu (2010)
Bioactives in blueberries improve insulin sensitivity in obese, insulin-resistant men and women.The Journal of nutrition, 140 10
C. Wild, A. Scalbert, Z. Herceg (2013)
Measuring the exposome: A powerful basis for evaluating environmental exposures and cancer riskEnvironmental and Molecular Mutagenesis, 54
Tri Vuong, Ali Benhaddou-Andaloussi, Ali Benhaddou-Andaloussi, A. Brault, A. Brault, D. Harbilas, D. Harbilas, Louis Martineau, Louis Martineau, D. Vallerand, D. Vallerand, C. Ramassamy, C. Matar, C. Matar, P. Haddad, P. Haddad (2009)
Antiobesity and antidiabetic effects of biotransformed blueberry juice in KKAy miceInternational Journal of Obesity, 33
T. Scarabelli, S. Mariotto, Safwat Abdel-Azeim, K. Shoji, E. Darra, A. Stephanou, C. Chen-Scarabelli, Jean‐Didier Maréchal, R. Knight, A. Ciampa, L. Saravolatz, A. Prati, Zhaokan Yuan, E. Cavalieri, M. Menegazzi, D. Latchman, C. Pizza, D. Pérahia, Hisanori Suzuki (2009)
Targeting STAT1 by myricetin and delphinidin provides efficient protection of the heart from ischemia/reperfusion‐induced injuryFEBS Letters, 583
Cancer Cell, 6
M. Hämäläinen, R. Nieminen, P. Vuorela, M. Heinonen, E. Moilanen (2007)
Anti-Inflammatory Effects of Flavonoids: Genistein, Kaempferol, Quercetin, and Daidzein Inhibit STAT-1 and NF-κB Activations, Whereas Flavone, Isorhamnetin, Naringenin, and Pelargonidin Inhibit only NF-κB Activation along with Their Inhibitory Effect on iNOS Expression and NO Production in ActivatedMediators of Inflammation, 2007
V. Shankaran, H. Ikeda, A. Bruce, J. White, P. Swanson, L. Old, R. Schreiber (2001)
IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicityNature, 410
D. Kaplan, V. Shankaran, A. Dighe, E. Stockert, M. Aguet, L. Old, R. Schreiber (1998)
Demonstration of an interferon γ-dependent tumor surveillance system in immunocompetent miceProceedings of the National Academy of Sciences of the United States of America, 95
L. Cantley (2002)
The phosphoinositide 3-kinase pathway.Science, 296 5573
R. Lange, L. Hillis (2004)
Antiplatelet therapy for ischemic heart disease.The New England journal of medicine, 350 3
P. Pignatelli, F. Pulcinelli, A. Celestini, L. Lenti, A. Ghiselli, P. Gazzaniga, F. Violi (2000)
The flavonoids quercetin and catechin synergistically inhibit platelet function by antagonizing the intracellular production of hydrogen peroxide.The American journal of clinical nutrition, 72 5
A. Rechner, C. Kroner (2005)
Anthocyanins and colonic metabolites of dietary polyphenols inhibit platelet function.Thrombosis research, 116 4
C. Wild (2005)
Complementing the Genome with an “Exposome”: The Outstanding Challenge of Environmental Exposure Measurement in Molecular EpidemiologyCancer Epidemiology Biomarkers & Prevention, 14
J. González‐Gallego, M. García‐Mediavilla, S. Sánchez‐Campos, M. Tuñón (2010)
Fruit polyphenols, immunity and inflammationBritish Journal of Nutrition, 104
S. Tsai, S. Lin-Shiau, Jen-kun Lin (1999)
Suppression of nitric oxide synthase and the down‐regulation of the activation of NFκB in macrophages by resveratrolBritish Journal of Pharmacology, 126
Lynn Adams, S. Phung, Natalie Yee, N. Seeram, Liya Li, Shiuan Chen (2010)
Blueberry phytochemicals inhibit growth and metastatic potential of MDA-MB-231 breast cancer cells through modulation of the phosphatidylinositol 3-kinase pathway.Cancer research, 70 9
I. Erlund, R. Koli, G. Alfthan, J. Marniemi, P. Puukka, P. Mustonen, P. Mattila, A. Jula (2008)
Favorable effects of berry consumption on platelet function, blood pressure, and HDL cholesterol.The American journal of clinical nutrition, 87 2
B. Aggarwal (2004)
Nuclear factor-κB: The enemy withinCancer Cell, 6
D. Waugh, Catherine Wilson (2008)
The Interleukin-8 Pathway in CancerClinical Cancer Research, 14
E. Blaak (2003)
Fatty acid metabolism in obesity and type 2 diabetes mellitusProceedings of the Nutrition Society, 62
G. Gordillo, Huiqing Fang, S. Khanna, J. Harper, G. Phillips, C. Sen (2009)
Oral administration of blueberry inhibits angiogenic tumor growth and enhances survival of mice with endothelial cell neoplasm.Antioxidants & redox signaling, 11 1
O. Vitseva, S. Varghese, S. Chakrabarti, J. Folts, J. Freedman (2005)
Grape Seed and Skin Extracts Inhibit Platelet Function and Release of Reactive Oxygen IntermediatesJournal of Cardiovascular Pharmacology, 46
K. Hochstenbach, D. Leeuwen, H. Gmuender, R. Gottschalk, M. Løvik, B. Granum, U. Nygaard, E. Namork, M. Kirsch‐Volders, Ilse Decordier, Kim Loock, H. Besselink, M. Törnqvist, H. Stedingk, P. Rydberg, J. Kleinjans, H. Loveren, J. Delft (2012)
Global Gene Expression Analysis in Cord Blood Reveals Gender-Specific Differences in Response to Carcinogenic Exposure In UteroCancer Epidemiology, Biomarkers & Prevention, 21
Cliona McHale, Luoping Zhang, Reuben Thomas, Martyn Smith (2013)
Analysis of the transcriptome in molecular epidemiology studiesEnvironmental and Molecular Mutagenesis, 54
D. Aaronson, C. Horvath (2002)
A Road Map for Those Who Don't Know JAK-STATScience, 296
L. Wilms, A. Boots, V. Boer, L. Maas, D. Pachen, Ralph Gottschalk, H. Ketelslegers, R. Godschalk, G. Haenen, F. Schooten, J. Kleinjans (2007)
Impact of multiple genetic polymorphisms on effects of a 4-week blueberry juice intervention on ex vivo induced lymphocytic DNA damage in human volunteers.Carcinogenesis, 28 8
P. Vineis, A. Khan, J. Vlaanderen, R. Vermeulen (2009)
The impact of new research technologies on our understanding of environmental causes of disease: the concept of clinical vulnerabilityEnvironmental Health, 8
Ji-young Bae, S. Lim, Sun Kim, Jung-Suk Choi, Jinseu Park, Sung Ju, S. Han, I. Kang, Young‐Hee Kang (2009)
Bog blueberry anthocyanins alleviate photoaging in ultraviolet-B irradiation-induced human dermal fibroblasts.Molecular nutrition & food research, 53 6
AbstractThe application of transcriptome analyses in molecular epidemiology studies has become a promising tool in order to evaluate the impact of environmental exposures. These analyses have a great value in establishing the exposome, the totality of human exposures, both by identifying the chemical nature of the exposures and the induced molecular responses. Transcriptomic signatures can be regarded as biomarker of exposure as well as markers of effect which reflect the interaction between individual genetic background and exposure levels. However, the biological interpretation of modulated gene expression profiles is a challenging task and translating affected molecular pathways into risk assessment, for instance in terms of cancer promoting or disease preventing responses, is a far from standardised process. Here, we describe the in-depth analyses of the gene expression responses in a human dietary intervention in which the interaction between genotype and exposure to a blueberry–apple juice containing a complex mixture of phytochemicals is investigated. We also describe how data on differences in genetic background combined with different effect markers can provide a better understanding of gene–environment interactions. Pathway analyses of differentially expressed genes in combination with gene were used to identify complex but strong changes in several biological processes like immune response, cell adhesion, lipid metabolism and apoptosis. These observed changes may lead to upgraded growth control, induced immunity, reduced platelet aggregation and activation, diminished production of reactive oxidative species by platelets, blood glucose homeostasis, regulation of blood lipid levels and increased apoptosis. Our findings demonstrate that applying transcriptomics to well-controlled human dietary intervention studies can provide insight into mechanistic pathways involved in disease prevention by dietary factors.
Mutagenesis – Oxford University Press
Published: Nov 1, 2015
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