Access the full text.
Sign up today, get DeepDyve free for 14 days.
G. Hill, Sandra Snider, T. Galbraith, Stephanie Forst, R. Robbins (1995)
Glucocorticoid reduction of bronchial epithelial inflammation during cardiopulmonary bypass.American journal of respiratory and critical care medicine, 152 6 Pt 1
Song Wan, J. Leclerc, J. Vincent (1997)
Inflammatory response to cardiopulmonary bypass: mechanisms involved and possible therapeutic strategies.Chest, 112 3
D. Taggart (2000)
Respiratory dysfunction after cardiac surgery: effects of avoiding cardiopulmonary bypass and the use of bilateral internal mammary arteries.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 18 1
J. Butler, G. Rocker, S. Westaby (1993)
Inflammatory response to cardiopulmonary bypass.The Annals of thoracic surgery, 55 2
G. Matheis, M. Scholz, J. Gerber, U. Abdel-Rahman, G. Wimmer‐Greinecker, A. Moritz (2001)
Leukocyte filtration in the early reperfusion phase on cardiopulmonary bypass reduces myocardial injuryPerfusion, 16
S. Baksaas, V. Videm, T. Mollnes, S. Tølløfsrud, G. Hetland, Thore Pedersen, J. Svennevig (1998)
Leucocyte filtration during cardiopulmonary bypass hardly changed leucocyte counts and did not influence myeloperoxidase, complement, cytokines or plateletsPerfusion, 13
T. Hurst, David Johnson, Bibiana Cujcc, D. Thomson, T. Mycyk, B. Burbridge, I. Mayers (1997)
Depletion of activated neutrophils by a filter during cardiac valve surgeryCanadian Journal of Anaesthesia, 44
S. Brett, G. Quinlan, J. Mitchell, J. Pepper, T. Evans (1998)
Production of nitric oxide during surgery involving cardiopulmonary bypass.Critical care medicine, 26 2
S. Kharitonov, D. Yates, R. Robbins, P. Barnes, R. Logan-Sinclair, E. Shinebourne (1994)
Increased nitric oxide in exhaled air of asthmatic patientsThe Lancet, 343
G. Hill (1996)
The Inflammatory Response to Cardiopulmonary BypassInternational Anesthesiology Clinics, 34
Ying-Fu Chen, W. Tsai, Ching-Cheng Lin, Chee‐Siong Lee, Chiung-Hui Huang, Pi-Chen Pan, Man-Lin Chen, Yeo-Shin Huang (2002)
Leukocyte depletion attenuates expression of neutrophil adhesion molecules during cardiopulmonary bypass in human beings.The Journal of thoracic and cardiovascular surgery, 123 2
S. Kharitonov, P. Barnes (1996)
Nitric oxide in exhaled air is a new marker of airway inflammation.Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace, 51 6
(2002)
Leucodepletion during cardiopulmonary bypass reduces renal injury in coronary revascularization: a prospective randomised study
G. Asimakopoulos (2001)
Systemic inflammation and cardiac surgery: an updatePerfusion, 16
W. Wagstaff (1995)
Clinical Application of Leukocyte DepletionJournal of Clinical Pathology, 48
P. Thurlow, L. Doolan, R. Sharp, M. Sullivan, B. Smith, LW Andersen (1996)
Laboratory studies of the effect of Pall extracorporeal leucocyte filters LG6 and AV6 on patients undergoing coronary bypass graftsPerfusion, 11
T. Mihaljevic, M. Tönz, L. Segesser, M. Pasic, P. Grob, J. Fehr, B. Seifert, M. Turina (1995)
The influence of leukocyte filtration during cardiopulmonary bypass on postoperative lung function. A clinical study.The Journal of thoracic and cardiovascular surgery, 109 6
D. Taggart, Mohammed El-Fiky, R. Carter, A. Bowman, D. Wheatley (1993)
Respiratory dysfunction after uncomplicated cardiopulmonary bypass.The Annals of thoracic surgery, 56 5
D. Palanzo, N. Manley, R. Montesano, Geary Yeisley, D. Gordon (1993)
Clinical evaluation of the LeukoGuard (LG-6) arterial line filter for routine open-heart surgeryPerfusion, 8
(1993)
Mechanisms of leukocyte removal with fibers
T. Ohto, F. Yamamoto, N. Nakajima (2000)
Evaluation of leukocyte-reducing arterial line filter (LG6) for postoperative lung function, using cardiopulmonary bypass.The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi, 48 5
S. Ohri (1996)
Systemic inflammatory response and the splanchnic bed in cardiopulmonary bypassPerfusion, 11
Yj Gu, A. DeVries, P. Boonstra, W. Oeveren (1996)
Leukocyte depletion results in improved lung function and reduced inflammatory response after cardiac surgery.The Journal of thoracic and cardiovascular surgery, 112 2
(1998)
Use of leucocyte depleting arterial line filter during deep hypothermic cardiopulmonary bypass and circulatory arrest
J. Smit, A. Vries, Y. Gu, W. Oeveren (2000)
Filtration of activated granulocytes during cardiopulmonary bypass surgery: a morphologic and immunologic study to characterize the trapped leukocytes.The Journal of laboratory and clinical medicine, 135 3
Objective: Leucocyte activation is central to end-organ damage that occurs during cardiac surgery under cardiopulmonary bypass (CPB). Exhaled nitric oxide (NO) increases in inflammatory lung conditions and has been proposed as a marker of pulmonary inflammation during CPB. This study examined the effect of leucodepletion on leucocyte activation, pulmonary inflammation and oxygenation in patients undergoing coronary revascularisation. Methods: Fifty low-risk patients undergoing first time coronary artery bypass graft (CABG) were randomised to two groups. Twenty-five patients had an arterial line leucocyte-depleting filter and 25 controls had a standard filter. Arterial blood samples were taken before CPB, 5 and 30 min on CPB, 5 min after aortic clamp removal and 6 h post-operatively. Activated leucocytes were identified with Nitroblue Tetrazolium staining. NO was sampled via an endotracheal teflon tube 15 min after median sternotomy before CPB and 30 min after discontinuation of CPB using a real-time chemiluminescense analyser. Respiratory index (alveolar-arterial oxygenation index, AaOI) was calculated before CPB, 1, 2, 4, 8 and 18 h post-operatively. Clinical outcome end-points were also recorded. Results: Total and activated leucocyte counts were significantly lower following leucodepletion during CPB (P<0.0001). Exhaled NO rose significantly after CPB in the control group (3.8±1 ppb/s before CPB vs 5.6±2 ppb/s after CPB (P=0.003),) but not in the leucodepleted group (3.7±1 ppb/s before CPB vs 3.9±1 ppb/s after CPB (P=0.51)). AaOIs were consistently lower after leucodepletion (anova, P=0.001). The duration of mechanical ventilation, the intensive care and hospital stay and the frequency of cardiac and respiratory complications were similar in the two groups. Conclusions: Leucodepletion reduces the numbers of circulating activated leucocytes and the pulmonary inflammation during CPB. This appears to limit lung injury and improve oxygenation in low-risk patients undergoing CABG surgery. Larger numbers of patients are required to evaluate the effect of continuous arterial line leucodepletion on the clinical outcome.
European Journal of Cardio-Thoracic Surgery – Oxford University Press
Published: Aug 1, 2004
Keywords: Coronary artery bypass grafting Leucocyte activation and depletion Lung function
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.