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The Acute Effects of Human Growth Hormone Administration on Thyroid Function in Normal Men

The Acute Effects of Human Growth Hormone Administration on Thyroid Function in Normal Men GH replacement therapy may lead to alterations in serum TSH and/or thyroid hormone values in GH-deficient patients, but there is no consensus on the explanation for these changes. We examined the effect of GH administration (0.125 mg, sc, daily for 4 days) on thyroid function in 20 normal men. Serum T4 levels decreased by 8%, and serum free T4 index values decreased by 5%. In contrast, serum T3 levels increased by 21%; serum rT3 did not change. These changes were accompanied by a 54% decrease in the mean serum TSH level. While it is not possible to draw conclusions about hormone production and disposal rates from changes in serum levels, these data are most consistent with enhanced extrathyroidal (including intrapituitary) conversion of T4 to T3 and a compensatory decrease in TSH secretion. This content is only available as a PDF. Author notes * This work was supported in part by grants from the V.A. Research Service, the NIH (DK-37102), and Genentech, Inc. † Clinical Investigator with the V.A. Copyright © 1988 by The Endocrine Society http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Clinical Endocrinology and Metabolism Oxford University Press

The Acute Effects of Human Growth Hormone Administration on Thyroid Function in Normal Men

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References (9)

Publisher
Oxford University Press
Copyright
Copyright © 1988 by The Endocrine Society
ISSN
0021-972X
eISSN
1945-7197
DOI
10.1210/jcem-67-5-1111
Publisher site
See Article on Publisher Site

Abstract

GH replacement therapy may lead to alterations in serum TSH and/or thyroid hormone values in GH-deficient patients, but there is no consensus on the explanation for these changes. We examined the effect of GH administration (0.125 mg, sc, daily for 4 days) on thyroid function in 20 normal men. Serum T4 levels decreased by 8%, and serum free T4 index values decreased by 5%. In contrast, serum T3 levels increased by 21%; serum rT3 did not change. These changes were accompanied by a 54% decrease in the mean serum TSH level. While it is not possible to draw conclusions about hormone production and disposal rates from changes in serum levels, these data are most consistent with enhanced extrathyroidal (including intrapituitary) conversion of T4 to T3 and a compensatory decrease in TSH secretion. This content is only available as a PDF. Author notes * This work was supported in part by grants from the V.A. Research Service, the NIH (DK-37102), and Genentech, Inc. † Clinical Investigator with the V.A. Copyright © 1988 by The Endocrine Society

Journal

Journal of Clinical Endocrinology and Metabolism – Oxford University Press

Published: Nov 1, 1988

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