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R. Walczak, E. Westhof, P. Carbon, A. Krol (1996)
A novel RNA structural motif in the selenocysteine insertion element of eukaryotic selenoprotein mRNAs.RNA, 2 4
S. Castellano, N. Morozova, M. Morey, Marla Berry, F. Serras, M. Corominas, R. Guigó (2001)
In silico identification of novel selenoproteins in the Drosophila melanogaster genomeEMBO reports, 2
J. Fletcher, P. Copeland, D. Driscoll, A. Krol (2001)
The selenocysteine incorporation machinery: interactions between the SECIS RNA and the SECIS-binding protein SBP2.RNA, 7 10
Novoselov (2007)
A highly efficient form of the selenocysteine insertion sequence element in protozoan parasites and its use in mammalian cellsProc. Natl Acad. Sci. USA, 104
D. Fagegaltier, A. Lescure, R. Walczak, P. Carbon, A. Krol (2000)
Structural analysis of new local features in SECIS RNA hairpins.Nucleic acids research, 28 14
G. Kryukov, V. Kryukov, V. Gladyshev (1999)
New Mammalian Selenocysteine-containing Proteins Identified with an Algorithm That Searches for Selenocysteine Insertion Sequence Elements*The Journal of Biological Chemistry, 274
E. Grundner-Culemann, G. Martin, J. Harney, Marla Berry (1999)
Two distinct SECIS structures capable of directing selenocysteine incorporation in eukaryotes.RNA, 5 5
A. Cléry, V. Bourguignon-Igel, C. Allmang, A. Krol, C. Branlant (2007)
An improved definition of the RNA-binding specificity of SECIS-binding protein 2, an essential component of the selenocysteine incorporation machineryNucleic Acids Research, 35
C. Buettner, J. Harney, M. Berry (1999)
The Caenorhabditis elegans Homologue of Thioredoxin Reductase Contains a Selenocysteine Insertion Sequence (SECIS) Element That Differs from Mammalian SECIS Elements but Directs Selenocysteine Incorporation*The Journal of Biological Chemistry, 274
Charles Chapple, R. Guigó (2008)
Relaxation of Selective Constraints Causes Independent Selenoprotein Extinction in Insect GenomesPLoS ONE, 3
A. Lobanov, D. Fomenko, Yan Zhang, Aniruddha Sengupta, D. Hatfield, V. Gladyshev (2007)
Evolutionary dynamics of eukaryotic selenoproteomes: large selenoproteomes may associate with aquatic life and small with terrestrial lifeGenome Biology, 8
A. Lescure, D. Gautheret, P. Carbon, A. Krol (1999)
Novel Selenoproteins Identified in Silico andin Vivo by Using a Conserved RNA Structural Motif*The Journal of Biological Chemistry, 274
G. Kryukov, S. Castellano, S. Novoselov, A. Lobanov, Omid Zehtab, R. Guigó, V. Gladyshev (2003)
Characterization of Mammalian SelenoproteomesScience, 300
Summary: Selenoproteins contain the 21st amino acid selenocysteine which is encoded by an inframe UGA codon, usually read as a stop. In eukaryotes, its co-translational recoding requires the presence of an RNA stem–loop structure, the SECIS element in the 3 untranslated region of (UTR) selenoprotein mRNAs. Despite little sequence conservation, SECIS elements share the same overall secondary structure. Until recently, the lack of a significantly high number of selenoprotein mRNA sequences hampered the identification of other potential sequence conservation. In this work, the web-based tool SECISaln provides for the first time an extensive structure-based sequence alignment of SECIS elements resulting from the well-defined secondary structure of the SECIS RNA and the increased size of the eukaryotic selenoproteome. We have used SECISaln to improve our knowledge of SECIS secondary structure and to discover novel, conserved nucleotide positions and we believe it will be a useful tool for the selenoprotein and RNA scientific communities.Availability: SECISaln is freely available as a web-based tool at http://genome.crg.es/software/secisaln/.Contact: charles.chapple@crg.esSupplementary information: Supplementary data are available at Bioinformatics online.
Bioinformatics – Oxford University Press
Published: Jan 29, 2009
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