Access the full text.
Sign up today, get DeepDyve free for 14 days.
R Ishihara, S Yamamoto, H Lishi (2010)
Factors predictive of tumor recurrence and survival after initial complete response of esophageal squamous cell carcinoma to definitive chemoradiotherapyInt J Radiat Oncol Biol Phys, 76
A Herskovic, K Martz, M Al-Sarraf (1992)
Combined chemotherapy and radiotherapy compared with radiotherapy alone in patients with cancer of esophagusN Engl J Med, 326
T Yano, M Muto, S Hattori (2008)
Long-term results of salvage endoscopic mucosal resection in patients with local failure after definitive chemoradiotherapy for esophageal squamous cell carcinomaEndoscopy, 40
A Suzuki, L Xiao, Y Hayashi (2012)
Nomograms for prognostication of outcome in patients with esophageal and gastroesophageal carcinoma undergoing definitive chemoradiotherapyOncology, 82
M Makazu, K Kato, H Takisawa (2014)
Feasibility of endoscopic mucosal resection as salvage treatment for patients with local failure after definitive chemoradiotherapy for stage IB, II, and III esophageal squamous cell cancerDis Esophagus, 27
K Nakajo, Y Yoda, K Hori (2018)
Technical feasibility of endoscopic submucosal dissection for local failure after chemoradiotherapy or radiotherapy for esophageal squamous cell carcinomaGastrointest Endosc, 88
A Ohtsu (2004)
Chemoradiotherapy for esophageal cancer: current status and perspectivesInt J Clin Oncol, 9
Y Saito, H Takisawa, H Suzuki (2008)
Endoscopic submucosal dissection of recurrent or residual superficial esophageal cancer after chemoradiotherapyGastrointest Endosc, 67
K Kato, K Muro, K Minashi (2011)
Phase II study of chemoradiotherapy with 5-fluorouracil and cisplatin for stage II-III esophageal squamous cell carcinoma: JCOG trial (JCOG 9906)Int J Radiat Oncol Biol Phys, 81
S Koizumi, M Jin, T Matsuhashi (2014)
Salvage endoscopic submucosal dissection for the esophagus-localized recurrence of esophageal squamous cell cancer after definitive chemoradiotherapyGastrointest Endosc, 79
S Hattori, M Muto, A Ohtsu (2003)
EMR as salvage treatment for patients with locoregional failure of definitive chemoradiotherapy for esophageal cancerGastrointest Endosc, 58
M Takeuchi, M Kobayashi, S Hashimoto (2013)
Salvage endoscopic submucosal dissection in patients with local failure after chemoradiotherapy for esophageal squamous cell carcinomaScand J Gastroenterol, 48
ObjectivesSalvage endoscopic resection is recommended when the local recurrence at primary site after chemoradiotherapy for esophageal squamous cell carcinoma is localized and superficial. This retrospective study aimed to comparatively analyse the short-term outcomes and local control of salvage endoscopic submucosal dissection versus salvage endoscopic mucosal resection for local recurrence after chemoradiotherapy or radiotherapy.MethodsA total of 96 patients who underwent initial salvage endoscopic resection for cT1N0M0 local recurrence after chemoradiotherapy or radiotherapy for esophageal squamous cell carcinoma between December 1998 and August 2019 patients were assigned to either the salvage endoscopic submucosal dissection (40 patients; 40 lesions) or salvage endoscopic mucosal resection (56 patients; 56 lesions) group. We evaluated the en bloc and R0 resection rates, severe adverse events and local failure rate after salvage endoscopic resection. Multivariate analysis was conducted to identify risk factors of local failure after salvage endoscopic resection.ResultsThe en bloc resection rate was significantly higher in the salvage endoscopic submucosal dissection group than in the salvage endoscopic mucosal resection group (95% versus 63%; P < 0.001). There were no differences in R0 resection rate between the two groups (73% versus 52%, P = 0.057). One patient (3%) in the salvage endoscopic submucosal dissection group had perforation. The 3-year cumulative local failure rate of salvage endoscopic mucosal resection was significantly higher than that of salvage endoscopic submucosal dissection (27% versus 5%, P = 0.032). In multivariate analysis, salvage endoscopic mucosal resection (hazard ratio: 2.7, P = 0.044) was the only independent risk factor of local failure after salvage endoscopic resection.ConclusionsSalvage endoscopic submucosal dissection is the effective treatment for local recurrence based on the short-term outcomes and local efficacy.
Japanese Journal of Clinical Oncology – Oxford University Press
Published: Jun 9, 2022
Keywords: endoscopic submucosal dissection; esophageal squamous cell carcinoma; chemoradiotherapy; endoscopic mucosal resection; salvage endoscopic resection
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.