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Role of apoptosis and cytokines in influenza virus morbidity

Role of apoptosis and cytokines in influenza virus morbidity AbstractInfluenza virus is a major human pathogen that causes epidemics and pandemics with increased morbidity and, especially in the elderly and those with pre-existing medical conditions, increased mortality. Influenza is characterised by respiratory symptoms and constitutional symptoms. Whilst knowledge of the mechanisms underlying host and tissue specificity has advanced considerably of late we still know relatively little about other aspects of influenza virus virulence. In this review, we will explore what is known about the role of apoptosis in respiratory epithelial cell damage and the role of cytokines in inflammation and constitutional symptoms with particular emphasis on the link between apoptosis, inflammation, fever and cytokine production. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png FEMS Microbiology Reviews Oxford University Press

Role of apoptosis and cytokines in influenza virus morbidity

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References (140)

Publisher
Oxford University Press
Copyright
© 2004 Federation of European Microbiological Societies.
ISSN
0168-6445
eISSN
1574-6976
DOI
10.1016/j.femsre.2004.12.003
pmid
16102605
Publisher site
See Article on Publisher Site

Abstract

AbstractInfluenza virus is a major human pathogen that causes epidemics and pandemics with increased morbidity and, especially in the elderly and those with pre-existing medical conditions, increased mortality. Influenza is characterised by respiratory symptoms and constitutional symptoms. Whilst knowledge of the mechanisms underlying host and tissue specificity has advanced considerably of late we still know relatively little about other aspects of influenza virus virulence. In this review, we will explore what is known about the role of apoptosis in respiratory epithelial cell damage and the role of cytokines in inflammation and constitutional symptoms with particular emphasis on the link between apoptosis, inflammation, fever and cytokine production.

Journal

FEMS Microbiology ReviewsOxford University Press

Published: Sep 9, 2005

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