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Response: Re: Prognostic Importance of Low c-erbB2 Expression in Breast Tumors

Response: Re: Prognostic Importance of Low c-erbB2 Expression in Breast Tumors protein levels were not statistically sig- cancerous breast—rather than from a normal breast—were compared with ad- nificantly more numerous in ER- negative tumors than in ER-positive tu- jacent tumor tissue. Finally, there may CORRESPONDENCE mors (chi-square 4 0.78; P 4 .37), have been differences in the patient while high c-erbB2 protein levels were populations. Our 44 patients with low statistically significantly more numer- c-erbB2 protein levels did not have par- ous in ER-negative tumors (P<.001), as ticularly adverse prognostic indicators: Re: Prognostic Importance of is found classically. When we examined 89% of them had fewer than three posi- Low c-erbB2 Expression in metastasis-free survival rates at 38 tive axillary lymph nodes, and a small Breast Tumors months (as had Koscielny) and 60 proportion had thymidine-kinase (7%), months according to c-erbB2 protein ex- urokinase plasminogen activator (7%), Numerous studies involving thou- pression (Table 1), the lowest metastasis and p53 values (9%) above their respec- th sands of patients have shown that c- rate was always observed in patients tive third quartiles (75 percentiles). erbB2 abnormalities (gene amplification with low c-erbB2 protein expression. In The link between low c-erbB2 pro- and protein overexpression) are associ- contrast, the highest metastasis rate was http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of the National Cancer Institute Oxford University Press

Response: Re: Prognostic Importance of Low c-erbB2 Expression in Breast Tumors

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References (3)

Publisher
Oxford University Press
Copyright
Oxford University Press
ISSN
0027-8874
eISSN
1460-2105
DOI
10.1093/jnci/91.18.1585
Publisher site
See Article on Publisher Site

Abstract

protein levels were not statistically sig- cancerous breast—rather than from a normal breast—were compared with ad- nificantly more numerous in ER- negative tumors than in ER-positive tu- jacent tumor tissue. Finally, there may CORRESPONDENCE mors (chi-square 4 0.78; P 4 .37), have been differences in the patient while high c-erbB2 protein levels were populations. Our 44 patients with low statistically significantly more numer- c-erbB2 protein levels did not have par- ous in ER-negative tumors (P<.001), as ticularly adverse prognostic indicators: Re: Prognostic Importance of is found classically. When we examined 89% of them had fewer than three posi- Low c-erbB2 Expression in metastasis-free survival rates at 38 tive axillary lymph nodes, and a small Breast Tumors months (as had Koscielny) and 60 proportion had thymidine-kinase (7%), months according to c-erbB2 protein ex- urokinase plasminogen activator (7%), Numerous studies involving thou- pression (Table 1), the lowest metastasis and p53 values (9%) above their respec- th sands of patients have shown that c- rate was always observed in patients tive third quartiles (75 percentiles). erbB2 abnormalities (gene amplification with low c-erbB2 protein expression. In The link between low c-erbB2 pro- and protein overexpression) are associ- contrast, the highest metastasis rate was

Journal

Journal of the National Cancer InstituteOxford University Press

Published: Sep 15, 1999

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