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S. Koscielny, P. Terrier, A. Daver, J. Wafflart, J. Goussard, G. Ricolleau, C. Delvincourt, J. Delarue (1998)
Quantitative determination of c-erbB-2 in human breast tumours: potential prognostic significance of low values.European journal of cancer, 34 4
S. Koscielny, P. Terrier, M. Spielmann, J. Delarue (1998)
Prognostic importance of low c-erbB2 expression in breast tumors.Journal of the National Cancer Institute, 90 9
R. Dittadi, A. Brazzale, G. Pappagallo, C. Salbe, O. Nascimben, A. Rosabian, M. Gion (1997)
ErbB2 assay in breast cancer: possibly improved clinical information using a quantitative method.Anticancer research, 17 2B
protein levels were not statistically sig- cancerous breast—rather than from a normal breast—were compared with ad- nificantly more numerous in ER- negative tumors than in ER-positive tu- jacent tumor tissue. Finally, there may CORRESPONDENCE mors (chi-square 4 0.78; P 4 .37), have been differences in the patient while high c-erbB2 protein levels were populations. Our 44 patients with low statistically significantly more numer- c-erbB2 protein levels did not have par- ous in ER-negative tumors (P<.001), as ticularly adverse prognostic indicators: Re: Prognostic Importance of is found classically. When we examined 89% of them had fewer than three posi- Low c-erbB2 Expression in metastasis-free survival rates at 38 tive axillary lymph nodes, and a small Breast Tumors months (as had Koscielny) and 60 proportion had thymidine-kinase (7%), months according to c-erbB2 protein ex- urokinase plasminogen activator (7%), Numerous studies involving thou- pression (Table 1), the lowest metastasis and p53 values (9%) above their respec- th sands of patients have shown that c- rate was always observed in patients tive third quartiles (75 percentiles). erbB2 abnormalities (gene amplification with low c-erbB2 protein expression. In The link between low c-erbB2 pro- and protein overexpression) are associ- contrast, the highest metastasis rate was
Journal of the National Cancer Institute – Oxford University Press
Published: Sep 15, 1999
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