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Reduction of Plasma Immunoreactive Somatomedin C during Fasting in Humans

Reduction of Plasma Immunoreactive Somatomedin C during Fasting in Humans Abstract We have assessed the effect of fasting for 10 days on plasma concentrations of immunoreactive somatomedin C and urinary urea excretion in seven obese male volunteers. From a mean prefast value of 0.83 U/ml, plasma somatomedin C fell to 0.21 U/ml after 10 days of fasting. A prompt increase was observed with refeeding. The change in somatomedin C during fasting showed a highly significant correlation with the change in urinary urea nitrogen excretion (r = 0.74; P < 0.001). It also was shown that inhibitors which interfere with quantitation in somatomedin bioassays are not observed in the RIA for somatomedin C. The results of this study suggest that measurement of plasma somatomedin C provides a sensitive indicator of nitrogen loss and may be useful in monitoring the changes in protein metabolism that occur during alterations in nutritional status. This content is only available as a PDF. Author notes * This work was supported by USPHS Research Grant AM-01022. The Massachusetts General Hospital Clinical Research Center is supported by Grant RR-01066 from the General Clinical Research Center Program of the Division of Research Resources. † Supported in part by the General Clinical Research Center grant RR00446. Judson J. Van Wyk is a recipient of a USPHS Research Career Award, 4 KOGA AM14115. Copyright © 1981 by The Endocrine Society http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Clinical Endocrinology and Metabolism Oxford University Press

Reduction of Plasma Immunoreactive Somatomedin C during Fasting in Humans

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References (16)

Publisher
Oxford University Press
Copyright
Copyright © 1981 by The Endocrine Society
ISSN
0021-972X
eISSN
1945-7197
DOI
10.1210/jcem-53-6-1247
Publisher site
See Article on Publisher Site

Abstract

Abstract We have assessed the effect of fasting for 10 days on plasma concentrations of immunoreactive somatomedin C and urinary urea excretion in seven obese male volunteers. From a mean prefast value of 0.83 U/ml, plasma somatomedin C fell to 0.21 U/ml after 10 days of fasting. A prompt increase was observed with refeeding. The change in somatomedin C during fasting showed a highly significant correlation with the change in urinary urea nitrogen excretion (r = 0.74; P < 0.001). It also was shown that inhibitors which interfere with quantitation in somatomedin bioassays are not observed in the RIA for somatomedin C. The results of this study suggest that measurement of plasma somatomedin C provides a sensitive indicator of nitrogen loss and may be useful in monitoring the changes in protein metabolism that occur during alterations in nutritional status. This content is only available as a PDF. Author notes * This work was supported by USPHS Research Grant AM-01022. The Massachusetts General Hospital Clinical Research Center is supported by Grant RR-01066 from the General Clinical Research Center Program of the Division of Research Resources. † Supported in part by the General Clinical Research Center grant RR00446. Judson J. Van Wyk is a recipient of a USPHS Research Career Award, 4 KOGA AM14115. Copyright © 1981 by The Endocrine Society

Journal

Journal of Clinical Endocrinology and Metabolism – Oxford University Press

Published: Dec 1, 1981

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