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1182 Letters to the Editor We read with interest the recent Journal commentary by edge, the goal of the more than 20 studies cited by Lawlor Lawlor et al. (1) regarding the utility of factor analysis in et al. has been to understand the underlying correlation struc- understanding the metabolic syndrome (MetS). We agree ture of the interrelated metabolic variables thought to consti- that the results of studies using exploratory factor analysis tute the syndrome. It is the other body of research mentioned should be interpreted with some caution given that it is not, by Lawlor et al., tests of whether MetS variables coexist to strictly speaking, a hypothesis-testing technique and that a greater degree than expected by chance (5–7), that might certain arbitrary decisions are necessarily made in using this provide evidence supporting the existence of a distinctive approach. These issues have been reviewed in detail pre- syndrome. Even these methods can only demonstrate the viously in this journal (2). We also agree that, in analyzing lack of independence among the risk factors and the plausi- the clinical importance of the MetS, it would be of value to bility of a syndrome. In any case, factor analysis is
American Journal of Epidemiology – Oxford University Press
Published: Jun 15, 2005
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