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Rat Placenta Is an Active Site of Inner Ring Deiodination of Thyroxine and 3,3′,5-Triiodothyronine

Rat Placenta Is an Active Site of Inner Ring Deiodination of Thyroxine and 3,3′,5-Triiodothyronine Inner ring deiodination of L-T4 and L-T3 by rat placental homogenates resulted in the generation of rT3 from T4 and 3,3′-diiodothyronine and 3′-monoiodothyronine from T3. Dithiothreitol is required in the incubation medium. There was little or no detectable outer ring deiodination of T4 and T3. These findings suggest that placental enzymatic inner ring monodeiodination of T4 and T3 could prevent the transplacental passage of T4 and T3 from dam to fetus. They also provide an explanation for our previous observations that fetal serum rT3 is partially dependent on maternal thyroid function. This content is only available as a PDF. Author notes * This work was presented in part at the AFCR/ASCI/AAP meetings in San Francisco, California, April 25–27, 1981, and was supported in part by NIH Research Grant AM-18919 (to L.E.B.) and Biomedical Research Support Grant 632704 (to C.H.E.). † Recipient of a NATO fellowship from the University of Parma, Parma, Italy. Copyright © 1982 by The Endocrine Society http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Endocrinology Oxford University Press

Rat Placenta Is an Active Site of Inner Ring Deiodination of Thyroxine and 3,3′,5-Triiodothyronine

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References (15)

Publisher
Oxford University Press
Copyright
Copyright © 1982 by The Endocrine Society
ISSN
0013-7227
eISSN
1945-7170
DOI
10.1210/endo-110-1-34
Publisher site
See Article on Publisher Site

Abstract

Inner ring deiodination of L-T4 and L-T3 by rat placental homogenates resulted in the generation of rT3 from T4 and 3,3′-diiodothyronine and 3′-monoiodothyronine from T3. Dithiothreitol is required in the incubation medium. There was little or no detectable outer ring deiodination of T4 and T3. These findings suggest that placental enzymatic inner ring monodeiodination of T4 and T3 could prevent the transplacental passage of T4 and T3 from dam to fetus. They also provide an explanation for our previous observations that fetal serum rT3 is partially dependent on maternal thyroid function. This content is only available as a PDF. Author notes * This work was presented in part at the AFCR/ASCI/AAP meetings in San Francisco, California, April 25–27, 1981, and was supported in part by NIH Research Grant AM-18919 (to L.E.B.) and Biomedical Research Support Grant 632704 (to C.H.E.). † Recipient of a NATO fellowship from the University of Parma, Parma, Italy. Copyright © 1982 by The Endocrine Society

Journal

Endocrinology – Oxford University Press

Published: Jan 1, 1982

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