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Radiation Dose Estimates in Indian Adults in Normal and Pathological Conditions due to 99Tcm-Labelled Radiopharmaceuticals

Radiation Dose Estimates in Indian Adults in Normal and Pathological Conditions due to... ICRP Publications 53, 62 and 80 give organ dose coefficients and effective doses to ICRP Reference Man and Child from established nuclear medicine procedures. However, an average Indian adult differs significantly from the ICRP Reference Man as regards anatomical, physiological and metabolic characteristics, and is also considered to have different tissue weighting factors (called here risk factors). The masses of total body and most organs are significantly lower for the Indian adult than for his ICRP counterpart (e.g. body mass 52 and 70 kg respectively). Similarly, the risk factors are lower by 20-30% for 8 out of the 13 organs and 30-60% higher for 3 organs. In the present study, available anatomical data of Indians and their risk factors have been utilised to estimate the radiation doses from administration of commonly used 99 Tc m -labelled radiopharmaceuticals under normal and certain pathological conditions. The following pathological conditions have been considered for phosphates/phosphonates - high bone uptake and severely impaired kidney function; IDA - parenchymal liver disease, occlusion of cystic duct, and occlusion of bile duct; DTPA - abnormal renal function; large colloids - early to intermediate diffuse parenchymal liver disease, intermediate to advanced parenchymal liver disease; small colloids - early to intermediate parenchymal liver disease, intermediate to advanced parenchymal liver disease; and MAG3 - abnormal renal function, acute unilateral renal blockage. The estimated 'effective doses' to Indian adults are 14-21% greater than the ICRP value from administration of the same activity of radiopharmaceutical under normal physiological conditions based on anatomical considerations alone, because of the smaller organ masses for the Indian; for some pathological conditions the effective doses are 11-22% more. When tissue risk factors are considered in addition to anatomical considerations, the estimated effective doses are still found to be generally somewhat higher for the Indian, for both normal and pathological states (but lower than the values based on anatomical considerations alone). However, when the radiopharmaceutical is administered in quantities proportional to the body mass, the effective doses are 11-28% lower for the Indian under both normal and pathological conditions. It may be concluded that Indians are at a lower risk of radiation health detriment in comparison with the ICRP adult on administration of the various 99 Tc m -labelled radiopharmaceuticals considered in this study. Radiation Protection Dosimetry « Previous | Next Article » Table of Contents This Article Radiat Prot Dosimetry (2001) 95 (1): 37-42. » Abstract Free Full Text (PDF) Free Classifications Article Services Article metrics Alert me when cited Alert me if corrected Find similar articles Similar articles in Web of Science Similar articles in PubMed Add to my archive Download citation Request Permissions Citing Articles Load citing article information Citing articles via CrossRef Citing articles via Scopus Citing articles via Web of Science Citing articles via Google Scholar Google Scholar Articles by Tyagi, K. Articles by C. Jain, P. Search for related content PubMed PubMed citation Articles by Tyagi, K. Articles by C. Jain, S. Articles by C. Jain, P. Related Content Load related web page information Share Email this article CiteULike Delicious Facebook Google+ Mendeley Twitter What's this? Search this journal: Advanced » Current Issue November 2015 167 (1-3) Alert me to new issues The Journal About this journal Special Issues Rights & Permissions Dispatch date of the next issue We are mobile – find out more Journals Career Network Impact factor: 0.913 5-Yr impact factor: 0.966 Editor-in-Chief Dr J. Zoetelief, The Netherlands View full editorial board For Authors Instructions to authors and online submission Submit now Self-archiving policy Open access options for authors - visit Oxford Open Alerting Services Email table of contents Email Advance Access CiteTrack XML RSS feed Corporate Services Advertising sales Reprints Supplements var taxonomies = ("SCI00180"); Most Most Read DETERMINATION OF 137CS AND 60CO POLLUTION IN THE AREA OF THE LAGUNA VERDE NUCLEAR POWER PLANT, MEXICO A report on radioactivity measurements of fish samples from the West Coast of Canada New ethical issues for radiation protection in diagnostic radiology Evaluation of radioactivity concentrations from the Fukushima nuclear accident in fish products and associated risk to fish consumers Canadian population risk of radon induced lung cancer: a re-assessment based on the recent cross-Canada radon survey » View all Most Read articles Most Cited The CERN-EU High-energy Reference Field (CERF) Facility for Dosimetry at Commercial Flight Altitudes and in Space Overview of Fluence-to-Effective Dose and Fluence-to-Ambient Dose Equivalent Conversion Coefficients for High Energy Radiation Calculated Using the FLUKA Code A software tool for increased efficiency in observer performance studies in radiology Physical Parameters and Dose Factors of the Radon and Thoron Decay Products Measurement of radioactivity in the soil of Bahawalpur division, Pakistan » View all Most Cited articles Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department. Online ISSN 1742-3406 - Print ISSN 0144-8420 Copyright © 2015 Oxford University Press Oxford Journals Oxford University Press Site Map Privacy Policy Cookie Policy Legal Notices Frequently Asked Questions Other Oxford University Press sites: Oxford University Press Oxford Journals China Oxford Journals Japan Academic & Professional books Children's & Schools Books Dictionaries & Reference Dictionary of National Biography Digital Reference English Language Teaching Higher Education Textbooks International Education Unit Law Medicine Music Online Products & Publishing Oxford Bibliographies Online Oxford Dictionaries Online Oxford English Dictionary Oxford Language Dictionaries Online Oxford Scholarship Online Reference Rights and Permissions Resources for Retailers & Wholesalers Resources for the Healthcare Industry Very Short Introductions World's Classics function fnc_onDomLoaded() { var query_context = getQueryContext(); PF_initOIUnderbar(query_context,":QS:default","","JRN"); PF_insertOIUnderbar(0); }; if (window.addEventListener) { window.addEventListener('load', fnc_onDomLoaded, false); } else if (window.attachEvent) { window.attachEvent('onload', fnc_onDomLoaded); } var gaJsHost = (("https:" == document.location.protocol) ? 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Radiation Dose Estimates in Indian Adults in Normal and Pathological Conditions due to 99Tcm-Labelled Radiopharmaceuticals

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Publisher
Oxford University Press
Copyright
Copyright © 2015 Oxford University Press
ISSN
0144-8420
eISSN
1742-3406
DOI
rpd;95/1/37
Publisher site
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Abstract

ICRP Publications 53, 62 and 80 give organ dose coefficients and effective doses to ICRP Reference Man and Child from established nuclear medicine procedures. However, an average Indian adult differs significantly from the ICRP Reference Man as regards anatomical, physiological and metabolic characteristics, and is also considered to have different tissue weighting factors (called here risk factors). The masses of total body and most organs are significantly lower for the Indian adult than for his ICRP counterpart (e.g. body mass 52 and 70 kg respectively). Similarly, the risk factors are lower by 20-30% for 8 out of the 13 organs and 30-60% higher for 3 organs. In the present study, available anatomical data of Indians and their risk factors have been utilised to estimate the radiation doses from administration of commonly used 99 Tc m -labelled radiopharmaceuticals under normal and certain pathological conditions. The following pathological conditions have been considered for phosphates/phosphonates - high bone uptake and severely impaired kidney function; IDA - parenchymal liver disease, occlusion of cystic duct, and occlusion of bile duct; DTPA - abnormal renal function; large colloids - early to intermediate diffuse parenchymal liver disease, intermediate to advanced parenchymal liver disease; small colloids - early to intermediate parenchymal liver disease, intermediate to advanced parenchymal liver disease; and MAG3 - abnormal renal function, acute unilateral renal blockage. The estimated 'effective doses' to Indian adults are 14-21% greater than the ICRP value from administration of the same activity of radiopharmaceutical under normal physiological conditions based on anatomical considerations alone, because of the smaller organ masses for the Indian; for some pathological conditions the effective doses are 11-22% more. When tissue risk factors are considered in addition to anatomical considerations, the estimated effective doses are still found to be generally somewhat higher for the Indian, for both normal and pathological states (but lower than the values based on anatomical considerations alone). However, when the radiopharmaceutical is administered in quantities proportional to the body mass, the effective doses are 11-28% lower for the Indian under both normal and pathological conditions. It may be concluded that Indians are at a lower risk of radiation health detriment in comparison with the ICRP adult on administration of the various 99 Tc m -labelled radiopharmaceuticals considered in this study. Radiation Protection Dosimetry « Previous | Next Article » Table of Contents This Article Radiat Prot Dosimetry (2001) 95 (1): 37-42. » Abstract Free Full Text (PDF) Free Classifications Article Services Article metrics Alert me when cited Alert me if corrected Find similar articles Similar articles in Web of Science Similar articles in PubMed Add to my archive Download citation Request Permissions Citing Articles Load citing article information Citing articles via CrossRef Citing articles via Scopus Citing articles via Web of Science Citing articles via Google Scholar Google Scholar Articles by Tyagi, K. Articles by C. Jain, P. Search for related content PubMed PubMed citation Articles by Tyagi, K. Articles by C. Jain, S. Articles by C. Jain, P. Related Content Load related web page information Share Email this article CiteULike Delicious Facebook Google+ Mendeley Twitter What's this? Search this journal: Advanced » Current Issue November 2015 167 (1-3) Alert me to new issues The Journal About this journal Special Issues Rights & Permissions Dispatch date of the next issue We are mobile – find out more Journals Career Network Impact factor: 0.913 5-Yr impact factor: 0.966 Editor-in-Chief Dr J. Zoetelief, The Netherlands View full editorial board For Authors Instructions to authors and online submission Submit now Self-archiving policy Open access options for authors - visit Oxford Open Alerting Services Email table of contents Email Advance Access CiteTrack XML RSS feed Corporate Services Advertising sales Reprints Supplements var taxonomies = ("SCI00180"); Most Most Read DETERMINATION OF 137CS AND 60CO POLLUTION IN THE AREA OF THE LAGUNA VERDE NUCLEAR POWER PLANT, MEXICO A report on radioactivity measurements of fish samples from the West Coast of Canada New ethical issues for radiation protection in diagnostic radiology Evaluation of radioactivity concentrations from the Fukushima nuclear accident in fish products and associated risk to fish consumers Canadian population risk of radon induced lung cancer: a re-assessment based on the recent cross-Canada radon survey » View all Most Read articles Most Cited The CERN-EU High-energy Reference Field (CERF) Facility for Dosimetry at Commercial Flight Altitudes and in Space Overview of Fluence-to-Effective Dose and Fluence-to-Ambient Dose Equivalent Conversion Coefficients for High Energy Radiation Calculated Using the FLUKA Code A software tool for increased efficiency in observer performance studies in radiology Physical Parameters and Dose Factors of the Radon and Thoron Decay Products Measurement of radioactivity in the soil of Bahawalpur division, Pakistan » View all Most Cited articles Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department. Online ISSN 1742-3406 - Print ISSN 0144-8420 Copyright © 2015 Oxford University Press Oxford Journals Oxford University Press Site Map Privacy Policy Cookie Policy Legal Notices Frequently Asked Questions Other Oxford University Press sites: Oxford University Press Oxford Journals China Oxford Journals Japan Academic & Professional books Children's & Schools Books Dictionaries & Reference Dictionary of National Biography Digital Reference English Language Teaching Higher Education Textbooks International Education Unit Law Medicine Music Online Products & Publishing Oxford Bibliographies Online Oxford Dictionaries Online Oxford English Dictionary Oxford Language Dictionaries Online Oxford Scholarship Online Reference Rights and Permissions Resources for Retailers & Wholesalers Resources for the Healthcare Industry Very Short Introductions World's Classics function fnc_onDomLoaded() { var query_context = getQueryContext(); PF_initOIUnderbar(query_context,":QS:default","","JRN"); PF_insertOIUnderbar(0); }; if (window.addEventListener) { window.addEventListener('load', fnc_onDomLoaded, false); } else if (window.attachEvent) { window.attachEvent('onload', fnc_onDomLoaded); } var gaJsHost = (("https:" == document.location.protocol) ? "https://ssl." : "http://www."); document.write(unescape("%3Cscript src='" + gaJsHost + "google-analytics.com/ga.js' type='text/javascript'%3E%3C/script%3E")); try { var pageTracker = _gat._getTracker("UA-189672-16"); pageTracker._setDomainName(".oxfordjournals.org"); pageTracker._trackPageview(); } catch(err) {}

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Radiation Protection DosimetryOxford University Press

Published: May 1, 2001

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