Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/oxford-university-press/purine-and-pyrimidine-metabolism-in-parasitic-protozoa-hnSy2ArxsG
References (275)
-
J. Marr, R. Berens, K. Chang, R. Bray (1985)
Purine and pyrimidine metabolism in Leishmania. -
M. Gottlieb, P. Gardiner, D. Dwyer (1986)
3'-nucleotidase activity in procyclic and bloodstream stages of Trypanosoma rhodesiense.Comparative biochemistry and physiology. B, Comparative biochemistry, 83 1
-
J. Coderre, S. Beverley, R. Schimke, D. Santi (1983)
Overproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica.Proceedings of the National Academy of Sciences of the United States of America, 80 8
-
W. Gutteridge, M. Gaborak (1979)
A re-examination of purine and pyrimidine synthesis in the three main forms of Trypanosoma cruzi.The International journal of biochemistry, 10 5
-
K. Pierre, G. Lepage (1968)
Formation of Inosine-5′-Monophosphate by a Kinase in Cell-Free Extracts of Ehrlich Ascites Cells in Vitro∗Proceedings of the Society for Experimental Biology and Medicine, 127
-
M. Jones (1980)
Pyrimidine nucleotide biosynthesis in animals: genes, enzymes, and regulation of UMP biosynthesis.Annual review of biochemistry, 49
-
C. Schimandle, L. Tanigoshi, L. Mole, I. Sherman (1985)
Purine nucleoside phosphorylase of the malarial parasite, Plasmodium lophurae.The Journal of biological chemistry, 260 7
-
S. Aldritt, P. Tien, C. Wang (1985)
Pyrimidine salvage in Giardia lambliaThe Journal of Experimental Medicine, 161
-
D. Nelson, S. Lafon, J. Tuttle, W. Miller, R. Miller, T. Krenitsky, G. Elion, R. Berens, J. Marr (1979)
Allopurinol ribonucleoside as an antileishmanial agent. Biological effects, metabolism, and enzymatic phosphorylation.The Journal of biological chemistry, 254 22
-
G. Kidder, V. Dewey, L. Nolan (1978)
Transport and accumulation of purine bases by Crithidia fasciculataJournal of Cellular Physiology, 96
-
A. Mukkada, J. Meade, T. Glaser, P. Bonventre (1985)
Enhanced metabolism of Leishmania donovani amastigotes at acid pH: an adaptation for intracellular growth.Science, 229 4718
-
S. Diggens, W. Gutteridge, P. Trigg (1970)
Altered Dihydrofolate Reductase associated with a Pyrimethamine-resistant Plasmodium berghei berghei produced in a Single StepNature, 228
-
A. Gero, G. Coombs (1982)
Leishmania mexicana: conversion of dihydroorotate to orotate in amastigotes and promastigotes.Experimental parasitology, 54 2
-
R. Miller, C. Sabourin, T. Krenitsky, R. Berens, J. Marr (1984)
Nucleoside hydrolases from Trypanosoma cruzi.The Journal of biological chemistry, 259 8
-
A. Irvin, D. Stagg (1977)
Theileria parva: purine and pyrimidine metabolism and the action of folate antagonists in parasitized bovine lymphoid cells.Experimental parasitology, 41 1
-
P. Lobelle-Rich, R. Reeves (1983)
The partial purification and characterization of adenosine kinase from Entamoeba histolytica.The American journal of tropical medicine and hygiene, 32 5
-
W. O'Sullivan, K. Ketley (1980)
Biosynthesis of uridine monophosphate in Plasmodium berghei.Annals of tropical medicine and parasitology, 74 2
-
M. Mundim, I. Roitman (1977)
Extra Nutritional Requirements of Artificially Aposymbiotic Crithidia deaneiJournal of Eukaryotic Microbiology, 24
-
D. Nelson, C. Buggé, H. Krasny, G. Elion (1973)
Formation of nucleotides of (6-14C)allopurinol and (6-14C)oxipurinol in rat tissues and effects on uridine nucleotide pools.Biochemical pharmacology, 22 16
-
R. Berens, J. Marr (1986)
Adenosine analog metabolism in Giardia lamblia. Implications for chemotherapy.Biochemical pharmacology, 35 23
-
F. Opperdoes, A. Markoš, R. Steiger (1981)
Localization of malate dehydrogenase, adenylate kinase and glycolytic enzymes in glycosomes and the threonine pathway in the mitochondrion of cultured procyclic trypomastigotes of Trypanosoma brucei.Molecular and biochemical parasitology, 4 5-6
-
P. Rainey, D. Santi (1983)
Metabolism and mechanism of action of formycin B in Leishmania.Proceedings of the National Academy of Sciences of the United States of America, 80 1
-
V. Dewey, G. Kidder, L. Nolan (1978)
Mechanism of inhibition of Crithidia fasciculata by adenosine and adenosine analogs.Biochemical pharmacology, 27 10
-
E. Koenigk (1977)
Salvage syntheses and their relationship to nucleic acid metabolism.Bulletin of the World Health Organization, 55 2-3
-
Stephen LaFon, Donald Nelson (1985)
Purine metabolism in the intact sporozoites and merozoites of Eimeria tenella.Molecular and biochemical parasitology, 14 1
-
L. Nolan, G. Kidder (1980)
Inhibition of growth and purine-metabolizing enzymes of trypanosomid flagellates by N6-methyladenineAntimicrobial Agents and Chemotherapy, 17
-
T. Spector, T. Jones (1982)
Guanosine 5'-monophosphate reductase from Leishmania donovani. A possible chemotherapeutic target.Biochemical pharmacology, 31 23
-
G. Kidder, V. Dewey, L. Nolan (1977)
Adenine deaminase of a eukaryotic animal cell, Crithidia fasciculata.Archives of biochemistry and biophysics, 183 1
-
U. Bachrach, S. Brem, S. Wertman, L. Schnur, C. Greenblatt (1979)
Leishmania spp.: effect of inhibitors on growth and on polyamine and macromolecular syntheses.Experimental parasitology, 48 3
-
Walter Rd, E. Koenigk (1974)
Hypoxanthine-guanine phosphoribosyltransferase and adenine phosphoribosyltransferase from Plasmodium chabaudi, purification and properties.Tropenmedizin und Parasitologie, 25 2
-
L. Simpson, P. Braly (1970)
Synchronization of Leishmania tarentolae by hydroxyurea.The Journal of protozoology, 17 4
-
P. Rathod, P. Reyes (1983)
Orotidylate-metabolizing enzymes of the human malarial parasite, Plasmodium falciparum, differ from host cell enzymes.The Journal of biological chemistry, 258 5
-
M. Ishizuka, T. Sawa, S. Hori, H. Takayama, T. Takeuchi (1968)
Biological studies on formycin and formycin B.The Journal of antibiotics, 21 1
-
P. Trigg, W. Gutteridge, J. Williamson (1971)
The effects of cordycepin on malaria parasites.Transactions of the Royal Society of Tropical Medicine and Hygiene, 65 4
-
R. Miller, D. Adamczyk, J. Rideout, T. Krenitsky (1982)
Purification, characterization, substrate and inhibitor specificity of adenosine kinase from several Eimeria species.Molecular and biochemical parasitology, 6 4
-
C. Schimandle, I. Sherman (1983)
Characterization of adenosine deaminase from the malarial parasite, Plasmodium lophurae, and its host cell, the duckling erythrocyte.Biochemical pharmacology, 32 1
-
R. Levine, N. Hoogenraad, N. Kretchmer (1974)
A Review: Biological and Clinical Aspects of Pyrimidine MetabolismPediatric Research, 8
-
P. Ogbunude, C. Ikediobi, A. Ukoha (1985)
Adenosine cycle in African trypanosomes.Annals of tropical medicine and parasitology, 79 1
-
G. Kidder, V. Dewey, L. Nolan (1976)
Enzymes of the orotate biosynthetic pathway in Crithidia fasciculata.Canadian journal of biochemistry, 54 1
-
C. Lantz, K. Dyke, G. Carter (1971)
Plasmodium berghei: in vitro incorporation of purine derivatives into nucleic acids.Experimental parasitology, 29 3
-
H. Hassan, G. Coombs (1986)
Purine-metabolising enzymes in Entamoeba histolytica.Molecular and biochemical parasitology, 19 1
-
D. Nelson, C. Buggé, G. Elion, R. Berens, J. Marr (1979)
Metabolism of pyrazolo(3,4-d)pyrimidines in Leishmania braziliensis and Leishmania donovani. Allopurinol, oxipurinol, and 4-aminopyrazolo(3,4-d)pyrimidine.The Journal of biological chemistry, 254 10
-
Trigg Pi, W. Gutteridge (1971)
A minimal medium for the growth of Plasmodium knowlesi in dilution culturesParasitology, 62
-
S. Aldritt, C. Wang (1986)
Purification and characterization of guanine phosphoribosyltransferase from Giardia lamblia.The Journal of biological chemistry, 261 18
-
A. Gero, K. Finney, J. Bennett, W. O'Sullivan (1981)
Comparative studies on dihydroorotate dehydrogenase from P. berghei and the mouse reticulocyte.The Australian journal of experimental biology and medical science, 59 4
-
B. Ullman, K. Kaur, T. Watts (1983)
Genetic studies on the role of the nucleoside transport function in nucleoside efflux, the inosine cycle, and purine biosynthesisMolecular and Cellular Biology, 3
-
D. Hammond, W. Gutteridge (1982)
UMP synthesis in the kinetoplastida.Biochimica et biophysica acta, 718 1
-
R. Berens, J. Marr, S. Lafon, D. Nelson (1981)
Purine metabolism in Trypanosoma cruzi.Molecular and biochemical parasitology, 3 3
-
A. Irvin, E. Young, R. Purnell (1978)
The in vitro uptake of tritiated nucleic acid precursors by Babesia spp. of cattle and mice.International journal for parasitology, 8 1
-
G. Boné, M. Steinert (1956)
Isotopes incorporated in the Nucleic Acids of Trypanosoma megaNature, 178
-
R. Brun, Schönenberger (1979)
Cultivation and in vitro cloning or procyclic culture forms of Trypanosoma brucei in a semi-defined medium. Short communication.Acta tropica, 36 3
-
A. Makoff, A. Radford (1978)
Genetics and biochemistry of carbamoyl phosphate biosynthesis and its utilization in the pyrimidine biosynthetic pathwayMicrobiological Reviews, 42
-
H. Hassan, G. Coombs (1985)
Leishmania mexicana: purine-metabolizing enzymes of amastigotes and promastigotes.Experimental parasitology, 59 2
-
K. Adam (1959)
The growth of Acanthamoeba sp. in a chemically defined medium.Journal of general microbiology, 21
-
H. Hassan, G. Coombs (1985)
Purine phosphoribosyltransferases of Leishmania mexicana mexicana and other flagellate protozoa.Comparative biochemistry and physiology. B, Comparative biochemistry, 82 4
-
T. Booden, R. Albach, P. Boonlayangoor (1978)
Uptake of selected pyrimidines by axenically grown Entamoeba histolytica.Archivos de investigacion medica, 9 Suppl 1
-
D. Hammond, W. Gutteridge (1984)
Purine and pyrimidine metabolism in the Trypanosomatidae.Molecular and biochemical parasitology, 13 3
-
W. Gutteridge, G. Coombs (1978)
Biochemistry of Parasitic Protozoa -
H. Lo, C. Wang (1985)
Purine salvage in Entamoeba histolytica.The Journal of parasitology, 71 5
-
J. Tuttle, T. Krenitsky (1980)
Purine phosphoribosyltransferases from Leishmania donovani.The Journal of biological chemistry, 255 3
-
J. Ávila, A. Bretaña, M. Casanova, A. Avila, F. Rodriguez (1979)
Trypanosoma cruzi: defined medium for continuous cultivation of virulent parasites.Experimental parasitology, 48 1
-
R. Miller, D. Adamczyk, W. Miller (1979)
Adenosine kinase from rabbit liver. I. Purification by affinity chromatography and properties.The Journal of biological chemistry, 254 7
-
J. Marr, R. Docampo (1986)
Chemotherapy for Chagas' disease: a perspective of current therapy and considerations for future research.Reviews of infectious diseases, 8 6
-
I. Lukow, G. Schmidt, R. Walter, E. Koenigk (1973)
[Adenosine monophosphate salvage synthesis in Plasmodium chabaudi].Zeitschrift fur Tropenmedizin und Parasitologie, 24 4
-
Mary Davies, A. Ross, W. Gutteridge (1983)
The enzymes of purine salvage in Trypanosoma cruzi, Trypanosoma brucei and Leishmania mexicanaParasitology, 87
-
E. Pfefferkorn, L. Pfefferkorn (1977)
Toxoplasma gondii: specific labeling of nucleic acids of intracellular parasites in Lesch-Nyhan cells.Experimental parasitology, 41 1
-
J. Marr, R. Berens, D. Nelson (1978)
Antitrypanosomal effect of allopurinol: conversion in vivo to aminopyrazolopyrimidine nucleotides by Trypanosoma curzi.Science, 201 4360
-
P. Heyworth, W. Gutteridge, C. Ginger (1984)
Pyrimidine metabolism in Trichomonas vaginalisFEBS Letters, 176
-
V. Okochi, A. Abaelu, E. Akinrimisi (1983)
Studies on the mechanism of adenosine transport in Trypanosoma vivax.Biochemistry international, 6 2
-
C. Ouellette, R. Strout, L. Mcdougald (1973)
Incorporation of radioactive pyrimidine nucleosides into DNA and RNA of Eimeria tenella (Coccidia) cultured in vitro.The Journal of protozoology, 20 1
-
R. Brun (1980)
Hydroxyurea: effect on growth, structure, and [3H]thymidine uptake of Trypanosoma brucei procyclic culture forms.The Journal of protozoology, 27 1
-
C. Walsh, I. Sherman (1968)
Purine and pyrimidine synthesis by the avian malaria parasite, Plasmodium lophurae.The Journal of protozoology, 15 4
-
E. Garvey, J. Coderre, D. Santi (1985)
Selection and properties of Leishmania tropica resistant to 10-propargyl-5,8-dideazafolate, an inhibitor of thymidylate synthetase.Molecular and biochemical parasitology, 17 1
-
Susan Tracy, I. Sherman (1972)
Purine uptake and utilization by the avian malaria parasite Plasmodium lophurae.The Journal of protozoology, 19 3
-
T. Asai, W. O'Sullivan, M. Kobayashi, A. Gero, M. Yokogawa, M. Tatibana (1983)
Enzymes of the de novo pyrimidine biosynthetic pathway in Toxoplasma gondii.Molecular and biochemical parasitology, 7 2
-
G. Kidder, L. Nolan (1973)
Pteridine-requiring dihydroorotate hydroxylase from Crithidia fasciculata.Biochemical and biophysical research communications, 53 3
-
W. Roberts, Y. Eisner, A. Shigematsu, D. Hammond (1970)
Lack of Incorporation of 3 H -Thymidine into Eimeria callospermophili in Cell CulturesJournal of Parasitology, 56
-
M. Manandhar, K. Dyke (1975)
Detailed purine salvage metabolism in and outside the free malarial parasite.Experimental parasitology, 37 2
-
J. Holland, A. Gero, W. O'Sullivan (1983)
Enzymes of de novo pyrimidine biosynthesis in Babesia rodhaini.The Journal of protozoology, 30 1
-
S. Sing, I. Willers, K. Held, H. Goedde (1985)
INVESTIGATION OF PURINE UTILISATION IN CULTURED FIBROBLASTS, AMNIOCYTES AND CHORIONIC VILLI : AN ATTEMPT TOWARDS UNDERSTANDING CLINICAL VARIABILITY IN LESCH NYHAN SYNDROME: 195Pediatric Research, 19
-
P. Boonlayangoor, R. Albach, T. Booden (1980)
Purine nucleotide synthesis in Entamoeba histolytica: a preliminary study.Archivos de investigacion medica, 11 1 Suppl
-
Raymond Blakley (1969)
The biochemistry of folic acid and related pteridines -
G. Schmidt, R. Walter, E. Koenigk (1975)
A purine nucleoside hydrolase from Trypanosoma gambiense, purification and properties.Tropenmedizin und Parasitologie, 26 1
-
R. Miller, G. Ramsey, T. Krenitsky, G. Elion (1972)
Guanine phosphoribosyltransferase from Escherichia coli, specificity and properties.Biochemistry, 11 25
-
C. Wang, H. Cheng (1984)
The deoxyribonucleoside phosphotransferase of Trichomonas vaginalis, 43
-
D. Hammond, R. Aman, C. Wang (1985)
The role of compartmentation and glycerol kinase in the synthesis of ATP within the glycosome of Trypanosoma brucei.The Journal of biological chemistry, 260 29
-
J. Marr, R. Berens, Donald Nelson, T. Krenitsky, Thomas Spector, Stephen LaFon, Gertrude Elion (1982)
Antileishmanial action of 4-thiopyrazolo (3.4-d) pyrimidine and its ribonucleoside. Biological effects and metabolism.Biochemical pharmacology, 31 2
-
L. Thelander, P. Reichard (1979)
Reduction of ribonucleotides.Annual review of biochemistry, 48
-
J. Berman, H. Webster (1982)
In vitro effects of mycophenolic acid and allopurinol against Leishmania tropica in human macrophagesAntimicrobial Agents and Chemotherapy, 21
-
S. Lafon, D. Nelson, R. Berens, J. Marr (1982)
Purine and pyrimidine salvage pathways in Leishmania donovani.Biochemical pharmacology, 31 2
-
R. Ferone, S. Roland (1980)
Dihydrofolate reductase: thymidylate synthase, a bifunctional polypeptide from Crithidia fasciculata.Proceedings of the National Academy of Sciences of the United States of America, 77 10
-
W. Büngener, G. Nielsen (1967)
[Nucleic acid metabolism in experimental malaria. 1. Studies on the incorporation of thymidine, uridine, and adenosine in the malaria parasite (Plasmodium berghei and Plasmodium vinckei)].Zeitschrift fur Tropenmedizin und Parasitologie, 18 4
-
D. Looker, J. Marr, R. Berens (1986)
Mechanisms of action of pyrazolopyrimidines in Leishmania donovani.The Journal of biological chemistry, 261 20
-
D. Hupe, B. Azzolina, N. Behrens (1986)
IMP dehydrogenase from the intracellular parasitic protozoan Eimeria tenella and its inhibition by mycophenolic acid.The Journal of biological chemistry, 261 18
-
D. Iovannisci, B. Ullman (1984)
Characterization of a mutant Leishmania donovani deficient in adenosine kinase activity.Molecular and biochemical parasitology, 12 2
-
E. Pfefferkorn (1981)
Toxoplasma gondii and the biochemistry of intracellular parasitismTrends in Biochemical Sciences, 6
-
P. Ogbunude, C. Ikediobi (1983)
Comparative aspects of purine metabolism in some African trypanosomes.Molecular and biochemical parasitology, 9 4
-
A. Coles, B. Swoboda, J. Ryley (1980)
Thymidylate synthetase as a chemotherapeutic target in the treatment of avian coccidiosis.The Journal of protozoology, 27 4
-
David Hart, Frederik Opperdoes (1984)
The occurrence of glycosomes (microbodies) in the promastigote stage of four major Leishmania species.Molecular and biochemical parasitology, 13 2
-
Richard Reeves, Betty West (1980)
Entamoeba histolytica: nucleic acid precursors affecting axenic growth.Experimental parasitology, 49 1
-
K. Chalabi, W. Gutteridge (1977)
Catabolism of deoxythymidylate in some trypanosomatidsParasitology, 74
-
K. Kriesten, W. Schmidtmann, U. Murawski (1986)
Iron and copper concentrations in the maternal and fetal serum, placenta and amniotic fluid during the reproductive stadium as well as in the milk of rabbits.Comparative biochemistry and physiology. A, Comparative physiology, 83 2
-
E. Scholar, P. Calabresi (1973)
Identification of the enzymatic pathways of nucleotide metabolism in human lymphocytes and leukemia cells.Cancer research, 33 1
-
K. Neame, P. Brownbill, C. Homewood (1974)
The uptake and incorporation of nucleosides into normal erythrocytes and erythrocytes containing Plasmodium bergheiParasitology, 69
-
J. Ávila, A. Avila (1981)
Trypanosoma cruzi: nucleotide and vitamin requirements of growing epimastigotes.Experimental parasitology, 51 3
-
T. Spector, T. Jones, S. Lafon, D. Nelson, R. Berens, J. Marr (1984)
Monophosphates of formycin B and allopurinol riboside. Interactions with leishmanial and mammalian succino-AMP synthetase and GMP reductase.Biochemical pharmacology, 33 10
-
Brian Hansen, H.Kyle Webster, Larry Hendricks, Michael Pappas (1984)
Leishmania mexicana: purine metabolism in promastigotes, axenic amastigotes, and amastigotes derived from Vero cells.Experimental parasitology, 58 1
-
C. Ouellette, R. Strout, L. Mcdougald (1974)
Thymidylic acid synthesis in Eimeria tenella (Coccidia) cultured in vitro.The Journal of protozoology, 21 2
-
C. Ceron, R. Caldas, C. Felix, M. Mundim, I. Roitman (1979)
Purine metabolism in trypanosomatids.The Journal of protozoology, 26 3
-
K. Muirhead, S. Bishop (1974)
Purification of adenylosuccinate synthetase from rabbit skeletal muscle.The Journal of biological chemistry, 249 2
-
K. Dyke, C. Szustkiewicz, C. Lantz, G. Tremblay (1970)
The source of purines and pyrimidines in Plasmodium berghei.The American journal of tropical medicine and hygiene, 19 2
-
A. Gero, K. Tetley, G. Coombs, R. Phillips (1981)
Dihydroorotate dehydrogenase, orotate phosphoribosyltransferase and orotidine-5'-phosphate decarboxylase in Plasmodium falciparum.Transactions of the Royal Society of Tropical Medicine and Hygiene, 75 5
-
M. Nagy, M. Djembo-Taty, Heslot (1973)
Regulation of the biosynthesis of purine nucleotides in Schizosaccharomyces pombe. 3. Kinetic studies of adenylosuccinate synthetase.Biochimica et biophysica acta, 309 1
-
B. Lowy, M. Williams, I. London (1962)
Enzymatic deficiencies of purine nucleotide synthesis in the human erythrocyte.The Journal of biological chemistry, 237
-
R. Momparler, J. Jaffe (1965)
EFFECT OF AZASERINE ON THE INCORPORATION OF 14-C-LABELED PURINES AND PYRIMIDINES INTO ACID-SOLUBLE AND NUCLEIC ACID FRACTIONS OF TRYPANOSOMA EQUIPERDUM.Biochemical pharmacology, 14
-
M. Mundim, Isaac Roitman, MARIA Hermans, ELLIOT Kitajima (1974)
Simple nutrition of Crithidia deanei, a reduviid trypanosomatid with an endosymbiont.The Journal of protozoology, 21 4
-
P. Daddona, W. Wiesmann, C. Lambros, W. Kelley, H. Webster (1984)
Human malaria parasite adenosine deaminase. Characterization in host enzyme-deficient erythrocyte culture.The Journal of biological chemistry, 259 3
-
W. Cosgrove, M. Skeen, S. Hajduk (1979)
Effects of hydroxyurea on Crithidia fasciculata.The Journal of protozoology, 26 4
-
H. Jantzen (1974)
Die Entwicklung von Acanthamoeba castellanii zur Cyste mit und ohne Veränderung des GenaktivitätsmustersJournal of Eukaryotic Microbiology, 21
-
C. Wang, A. Wang, A. Rice (1984)
Tritrichomonas foetus: partly defined cultivation medium for study of the purine and pyrimidine metabolism.Experimental parasitology, 57 1
-
J. Schwartzman, E. Pfefferkorn (1982)
Toxoplasma gondii: purine synthesis and salvage in mutant host cells and parasites.Experimental parasitology, 53 1
-
A. Gero, G. Coombs (1982)
Pyrimidine biosynthetic enzymes in Babesia hylomysci.International journal for parasitology, 12 5
-
K. Yamada, I. Sherman (1981)
Purine metabolism by the avian malarial parasite Plasmodium lophurae.Molecular and biochemical parasitology, 3 4
-
G. Peters, J. Veerkamp (1983)
Purine and pyrimidine metabolism in peripheral blood lymphocytes.The International journal of biochemistry, 15 2
-
W. Sirawaraporn, Y. Yuthavong (1984)
Kinetic and molecular properties of dihydrofolate reductase from pyrimethamine-sensitive and pyrimethamine-resistant Plasmodium chabaudi.Molecular and biochemical parasitology, 10 3
-
Amos Cohen, J. Barankiewicz, Howard Lederman, Erwin Gelfand (1983)
Purine and pyrimidine metabolism in human T lymphocytes. Regulation of deoxyribonucleotide metabolism.The Journal of biological chemistry, 258 20
-
D. Looker, R. Berens, J. Marr (1983)
Purine metabolism in Leishmania donovani amastigotes and promastigotes.Molecular and biochemical parasitology, 9 1
-
T. Spector, R. Berens, J. Marr (1982)
Adenylosuccinate synthetase and adenylosuccinate lyase from Trypanosoma cruzi, Specificity studies with potential chemotherapeutic agents.Biochemical pharmacology, 31 2
-
L. Fontenelle, J. Henderson (1969)
An enzymatic basis for the inability of erythrocytes to synthesize purine ribonucleotides de novo.Biochimica et biophysica acta, 177 1
-
C. Wang, Hui Cheng (1984)
Salvage of pyrimidine nucleosides by Trichomonas vaginalis.Molecular and biochemical parasitology, 10 2
-
H. Hassan, G. Coombs (1987)
Phosphomonoesterases of Leishmania mexicana mexicana and other flagellates.Molecular and biochemical parasitology, 23 3
-
J. Jaffe (1961)
The effect of 6-azauracil upon Trypanosoma equiperdum.Biochemical pharmacology, 8
-
V. Dewey, G. Kidder (1977)
Inhibitory action of the adenine analog, 4-aminopyrazolo(3,4-d)pyrimidine, in Crithidia fasciculata.Canadian journal of biochemistry, 55 1
-
Lloyd Kasper, E. Pfefferkorn (1982)
Hydroxyurea inhibition of growth and DNA synthesis in Toxoplasma gondii: characterization of a resistant mutant.Molecular and biochemical parasitology, 6 3
-
E. Pfefferkorn, L. Pfefferkorn (1977)
Specific labeling of intracellular Toxoplasma gondii with uracil.The Journal of protozoology, 24 3
-
S. Yoneda (1971)
Some aspects of the purine metabolism of Trypanosoma cruzi in tissue culture.Revista brasileira de pesquisas medicas e biologicas, 4 3
-
A. Irvin, E. Young (1979)
Further studies on the uptake of tritiated nucleic acid precursors by Babesia spp. of cattle and miceInternational Journal for Parasitology, 9
-
R. Steiger, E. Steiger (1977)
Cultivation of Leishmania donovani and Leishmania braziliensis in defined media: nutritional requirements.The Journal of protozoology, 24 3
-
B. Aronow, K. Kaur, K. McCartan, B. Ullman (1987)
Two high affinity nucleoside transporters in Leishmania donovani.Molecular and biochemical parasitology, 22 1
-
R. Pascal, N. Trang, A. Cerami, C. Walsh (1983)
Purification and properties of dihydroorotate oxidase from Crithidia fasciculata and Trypanosoma brucei.Biochemistry, 22 1
-
G. Kidder, L. Nolan (1981)
The in vivo and in vitro action of 4-amino-5-imidazolecarboxamide in trypanosomatid flagellates.Molecular and biochemical parasitology, 3 5
-
E. Garvey, D. Santi (1985)
Limited proteolysis of the bifunctional thymidylate synthase-dihydrofolate reductase from Leishmania tropica.Proceedings of the National Academy of Sciences of the United States of America, 82 21
-
G. Kidder, L. Nolan, V. Dewey (1979)
The purine phosphoribosyltransferases of Crithidia fasciculata.The Journal of parasitology, 65 4
-
T. Spector, T. Jones, G. Elion (1979)
Specificity of adenylosuccinate synthetase and adenylosuccinate lyase from Leishmania donovani. Selective amination of an antiprotozoal agent.The Journal of biological chemistry, 254 17
-
D. Lindmark, E. Jarroll (1982)
Pyrimidine metabolism in Giardia lamblia trophozoites.Molecular and biochemical parasitology, 5 5
-
S. Yoneda, R. Carvalho, B. Castellani (1974)
Synthesis of pyrimidic base by intracellular forms of Toxoplasma gondii in cell culture.Revista do Instituto de Medicina Tropical de Sao Paulo, 16 6
-
Narsingh Sharma, R. Albach, James Shaffer (1969)
Autoradiographic studies of uridine-5-H3 uptake in Entamoeba histolytica in the CLG medium.The Journal of protozoology, 16 3
-
S. Pragobpol, A. Gero, C. Lee, W. O'Sullivan (1984)
Orotate phosphoribosyltransferase and orotidylate decarboxylase from Crithidia luciliae: subcellular location of the enzymes and a study of substrate channeling.Archives of biochemistry and biophysics, 230 1
-
A. Mcintosh, R. Chang (1971)
A comparative study of 4 strains of hartmannellid amoebae.The Journal of protozoology, 18 4
-
A. Murray (1971)
The biological significance of purine salvage.Annual review of biochemistry, 40
-
T. Meek, E. Garvey, D. Santi (1985)
Purification and characterization of the bifunctional thymidylate synthetase-dihydrofolate reductase from methotrexate-resistant Leishmania tropica.Biochemistry, 24 3
-
R. Walter (1986)
Altered dihydrofolate reductase in pyrimethamine-resistant Plasmodium falciparum.Molecular and biochemical parasitology, 19 1
-
R. Ferone, Mary O'Shea, M. Yoeli (1970)
Altered Dihydrofolate Reductase Associated with Drug-Resistance Transfer between Rodent PlasmodiaScience, 167
-
G. Coombs, H. Hassan, B. Lockwood, D. Mallinson, M. North, J. Alunda, L. Tetley (1987)
Phosphomonoesterases and Proteinases of Leishmanias -
R. Coulson (1986)
Metabolic rate and the flow theory: a study in chemical engineering.Comparative biochemistry and physiology. A, Comparative physiology, 84 2
-
G. O'donovan, J. Neuhard (1970)
Pyrimidine metabolism in microorganisms.Bacteriological reviews, 34 3
-
D. Linstead (1981)
New defined and semi-defined media for cultivation of the flagellate Trichomonas vaginalisParasitology, 83
-
G. Koszalka, T. Krenitsky (1985)
5′-METHYLTHIOADENOSINE (MTA) PHOSPHORYLASE FROM LEISHMANIA DONOVANI: 103Pediatric Research, 19
-
Celina Roitman, Isaac Roitman, H. Azevedo (1972)
Growth of an insect Trypanosomatid at 37 C in a defined medium.The Journal of protozoology, 19 2
-
R. Berens, J. Marr, D. Nelson, S. Lafon (1980)
Antileishmanial effect of allopurinol and allopurinol ribonucleoside on intracellular forms of Leishmania donovani.Biochemical pharmacology, 29 17
-
J. Marr, R. Berens (1983)
Pyrazolopyrimidine metabolism in the pathogenic trypanosomatidae.Molecular and biochemical parasitology, 7 4
-
H. Webster, J. Whaun, M. Walker, T. Bean (1984)
Synthesis of adenosine nucleotides from hypoxanthine by human malaria parasites (Plasmodium falciparum) in continuous erythrocyte culture: inhibition by hadacidin but not alanosine.Biochemical pharmacology, 33 9
-
S. Tampitag, W. O'Sullivan (1986)
Enzymes of pyrimidine biosynthesis in Crithidia luciliae.Molecular and biochemical parasitology, 19 2
-
J. Schwartzman, E. Pfefferkorn (1981)
Pyrimidine synthesis by intracellular Toxoplasma gondii.The Journal of parasitology, 67 2
-
C. Wang, P. Simashkevich, R. Stotish (1979)
Mode of anticoccidal action of arprinocidBiochemical Pharmacology, 28
-
C. Wang, S. Aldritt (1983)
Purine salvage networks in Giardia lambliaThe Journal of Experimental Medicine, 158
-
A. Gero, W. O'Sullivan, I. Wright, D. Mahoney (1983)
The enzymes of pyrimidine biosynthesis in Babesia bovis and Babesia bigemina.The Australian journal of experimental biology and medical science, 61 (Pt 2)
-
E. Koenigk, S. Rasoul (1978)
Catabolism of adenosine 5'-monophosphate in promastigotes of Leishmania tropica.Tropenmedizin und Parasitologie, 29 3
-
I. Roitman, J. Angluster, J. Fiorini (1985)
Nutrition of the trypanosomatids Crithidia acanthocephali and C. harmosa. Ribose and adenosine: substrates for C. acanthocephaliJournal of Eukaryotic Microbiology, 32
-
P. Heyworth, W. Gutteridge, C. Ginger (1982)
Purine metabolism in Trichomonas vaginalisFEBS Letters, 141
-
G. Kidder, B. Dutta (1958)
The growth and nutrition of Crithidia fasciculata.Journal of general microbiology, 18 3
-
T. Krenitsky, G. Koszalka, J. Tuttle, D. Adamczyk, G. Elion, J. Marr (1979)
Purine salvage enzymes in man and Leishmania donovani.Advances in experimental medicine and biology, 122B
-
A. Gero, G. Brown, W. O'Sullivan (1984)
Pyrimidine de novo synthesis during the life cycle of the intraerythrocytic stage of Plasmodium falciparum.The Journal of parasitology, 70 4
-
C. Wang, R. Stotish, M. Poe (1975)
Dihydrofolate reductase from Eimeria tenella: rationalization of chemotherapeutic efficacy of pyrimethamine.The Journal of protozoology, 22 4
-
G. Koszalka, T. Krenitsky (1979)
Nucleosidases from Leishmania donovani. Pyrimidine ribonucleosidase, purine ribonucleosidase, and a novel purine 2'-deoxyribonucleosidase.The Journal of biological chemistry, 254 17
-
J. Hochstadt (1978)
[76] Adenine phosphoribosyltransferase from Escherichia coliMethods in Enzymology, 51
-
C. Wang, H. Cheng (1984)
The deoxyribonucleoside phosphotransferase of Trichomonas vaginalis. A potential target for anti-trichomonial chemotherapyThe Journal of Experimental Medicine, 160
-
C. Wang, R. Verham, A. Rice, S. Tzeng (1983)
Purine salvage by Tritrichomonas foetus.Molecular and biochemical parasitology, 8 4
-
W. Gutteridge, M. Davies (1982)
Properties of the purine phosphoribosyltransferases of Trypanosoma cruziFems Microbiology Letters, 13
-
B. Newton (1957)
Nutritional requirements and biosynthetic capabilities of the parasitic flagellate Strigomonas oncopelti.Journal of general microbiology, 17 3
-
R. Berens, J. Marr, R. Brun (1980)
Pyrazolopyrimidine metabolism in African trypanosomes: metabolic similarities to Trypanosoma cruzi and Leishmania spp.Molecular and biochemical parasitology, 1 2
-
C. Wang, R. Verham, S. Tzeng, S. Aldritt, H. Cheng (1983)
Pyrimidine metabolism in Tritrichomonas foetus.Proceedings of the National Academy of Sciences of the United States of America, 80 9
-
S. Yoneda, R. Carvalho, M. Quiroga (1974)
Aspects of pyrimidine biosynthesis of Trypanosoma cruzi.Revista do Instituto de Medicina Tropical de Sao Paulo, 16 6
-
Melo Nm, de Hp, I. Roitman, W. Mayrink (1985)
A new defined medium for cultivating Leishmania promastigotes.Acta tropica, 42 2
-
G. Tremblay, D. Crandall, C. Knott, M. Alfant (1977)
Orotic acid biosynthesis in rat liver: studies on the source of carbamoylphosphate.Archives of biochemistry and biophysics, 178 1
-
Paul Chello, J. Jaffe (1972)
Comparative properties of trypanosomal and mammalian thymidine kinases.Comparative biochemistry and physiology. B, Comparative biochemistry, 43 3
-
Hansen Bd, Sleeman Hk, Pappas Pw (1980)
Purine base and nucleoside uptake in Plasmodium berghei and host erythrocytes.Journal of Parasitology, 66
-
S. Pattanakitsakul, A. Ratanaphan, P. Ruenwongsa (1985)
Comparative studies on thymidylate synthetase from P. berghei and mouse reticulocytes.Comparative biochemistry and physiology. B, Comparative biochemistry, 80 3
-
D. Hammond, W. Gutteridge, F. Opperdoes (1981)
A novel location for two enzymes of de novo pyrimidine biosynthesis in trypanosomes and LeishmaniaFEBS Letters, 128
-
H. Scott, A. Gero, W. O'Sullivan (1986)
In vitro inhibition of Plasmodium falciparum by pyrazofurin, an inhibitor of pyrimidine biosynthesis de novo.Molecular and biochemical parasitology, 18 1
-
P. Rainey, C. Garrett, D. Santi (1983)
The metabolism and cytotoxic effects of Formycin B in Trypanosoma cruzi.Biochemical pharmacology, 32 4
-
C. Wang (1984)
Parasite enzymes as potential targets for antiparasitic chemotherapy.Journal of medicinal chemistry, 27 1
-
C. Wang, R. Verham, H. Cheng, A. Rice, A. Wang (1984)
Differential effects of inhibitors of purine metabolism on two trichomonad species.Biochemical pharmacology, 33 8
-
R. Jackson, M. Lui, T. Boritzki, H. Morris, G. Weber (1980)
Purine and pyrimidine nucleotide patterns of normal, differentiating, and regenerating liver and of hepatomas in rats.Cancer research, 40 4
-
B. Hill, J. Kilsby, G. Rogerson, R. McIntosh, C. Ginger (1981)
The enzymes of pyrimidine biosynthesis in a range of parasitic protozoa and helminths.Molecular and biochemical parasitology, 2 3-4
-
W. O'Sullivan, A. Johnson, K. Finney, A. Gero, E. Hagon, J. Holland, G. Smithers (1981)
Pyrimidine and purine enzymes in Toxoplasma gondii.The Australian journal of experimental biology and medical science, 59 Pt 6
-
D. Hammond, W. Gutteridge (1983)
Studies on the glycosomal orotate phosphoribosyl transferase of Trypanosoma cruzi.Molecular and biochemical parasitology, 7 4
-
D. Nelson, S. Lafon, T. Jones, T. Spector, R. Berens, J. Marr (1982)
The metabolism of formycin B in Leishmania donovani.Biochemical and biophysical research communications, 108 1
-
E. Koenigk, B. Putfarken (1980)
Stage-specific differences of a perhaps signal-transferring system in Leishmania donovani.Tropenmedizin und Parasitologie, 31 4
-
R. Berens, J. Marr, F. Cruz, Donald Nelson (1982)
Effect of allopurinol on Trypanosoma cruzi: metabolism and biological activity in intracellular and bloodstream formsAntimicrobial Agents and Chemotherapy, 22
-
V. Dewey, G. Kidder (1973)
Partial purification and properties of a nucleoside hydrolase from Crithidia.Archives of biochemistry and biophysics, 157 2
-
H. Umezawa, T. Sawa, Y. Fukagawa, I. Homma, M. Ishizuka (1967)
Studies on formycin and formycin B in cells of Ehrlich carcinoma and E. coli.The Journal of antibiotics, 20 6
-
T. Matsuno, N. Kobayashi, F. Hariguchi, T. Yamazaki, K. Imai, H. Onaga (1984)
Eimeria tenella, E. necatrix, E. acervulina, and E. maxima: anticoccidial activity of 1,6-dihydro-6-oxo-2-pyrazinecarboxylic acid 4-oxide.Experimental parasitology, 57 1
-
P. Conrad (1986)
Uptake of tritiated nucleic acid precursors by Babesia bovis in vitro.International journal for parasitology, 16 3
-
R. Miller, C. Sabourin, T. Krenitsky (1987)
Trypanosoma cruzi adenine nucleoside phosphorylase. Purification and substrate specificity.Biochemical pharmacology, 36 4
-
W. Fish, D. Looker, J. Marr, R. Berens (1982)
Purine metabolism in the bloodstream forms of Trypanosoma gambiense and Trypanosoma rhodesiense.Biochimica et biophysica acta, 719 2
-
W. Gutteridge, P. Trigg (1970)
Incorporation of radioactive precursors into DNA and RNA of Plasmodium knowlesi in vitro.The Journal of protozoology, 17 1
-
R. Rubin, J. Jaffe, R. Handschumacher (1962)
Qualitative differences in the pyrimidine metabolism of Trypanosoma equiperdum and mammals as characterized by 6-azauracil and 6-azauridine.Biochemical pharmacology, 11
-
P. Daddona, W. Wiesmann, W. Milhouse, J. Chern, Leroy Townsend, Michael Hershfield, H. Webster (1986)
Expression of human malaria parasite purine nucleoside phosphorylase in host enzyme-deficient erythrocyte culture. Enzyme characterization and identification of novel inhibitors.The Journal of biological chemistry, 261 25
-
J. Marr, R. Berens, Donald Nelson (1978)
Purine metabolism in Leishmania donovani and Leishmania braziliensis.Biochimica et biophysica acta, 544 2
-
Amos Cohen, Buddy Ullman, David Martin (1979)
Characterization of a mutant mouse lymphoma cell with deficient transport of purine and pyrimidine nucleosides.The Journal of biological chemistry, 254 1
-
P. Boonlayangoor, R. Albach, M. Stern, T. Booden (1978)
Entamoeba histolytica: uptake of purine bases and nucleosides during axenic growth.Experimental parasitology, 45 2
-
E. Jarroll, D. Lindmark, P. Paolella (1983)
Pyrimidine metabolism in Tritrichomonas foetus.The Journal of parasitology, 69 5
-
I. Sherman (1979)
Biochemistry of Plasmodium (malarial parasites).Microbiological reviews, 43 4
-
Richard Miller, W. Miller (1985)
PURINE SALVAGE ENZYMES IN TRICHOMONAS VAGINALIS: 133Pediatric Research, 19
-
H. Hassan, G. Coombs (1986)
A comparative study of the purine- and pyrimidine-metabolising enzymes of a range of trypanosomatids.Comparative biochemistry and physiology. B, Comparative biochemistry, 84 2
-
R. Berens, J. Marr, D. Looker, D. Nelson, S. Lafon (1984)
Efficacy of pyrazolopyrimidine ribonucleosides against Trypanosoma cruzi: studies in vitro and in vivo with sensitive and resistant strains.The Journal of infectious diseases, 150 4
-
G. Lepage, I. Junga (1963)
Use of nucleosides in resistance to 6-thioguanine.Cancer research, 23
-
Michael Gottlieb, Dennis Dwyer (1983)
Evidence for distinct 5'- and 3'-nucleotidase activities in the surface membrane fraction of Leishmania donovani promastigotes.Molecular and biochemical parasitology, 7 4
-
W. Eubank, R. Reeves (1981)
Growth inhibition of axenic Entamoeba histolytica by tubercidin and ara-A.The American journal of tropical medicine and hygiene, 30 4
-
T. Krenitsky, J. Rideout, G. Koszalka, R. Inmon, E. Chao, G. Elion, V. Latter, R. Williams (1982)
Pyrazolo[3,4-d]pyrimidine ribonucleosides as anticoccidials. 1. Synthesis and activity of some nucleosides of purines and 4-(alkylthio)pyrazolo[3,4-d]pyrimidines.Journal of medicinal chemistry, 25 1
-
A. Mitchell, L. Finch (1977)
Pathways of Nucleotide Biosynthesis in Mycoplasma mycoides subsp. mycoidesJournal of Bacteriology, 130
-
E. Pfefferkorn (1978)
Toxoplasma gondii: the enzymic defect of a mutant resistant to 5-fluorodeoxyuridine.Experimental parasitology, 44 1
-
W. Washtien, R. Grumont, D. Santi (1985)
DNA amplification in antifolate-resistant Leishmania. The thymidylate synthase-dihydrofolate reductase gene and abundant mRNAs.The Journal of biological chemistry, 260 13
-
N. Pereira, E. Koenigk (1981)
A nucleotidase from Leishmania tropica Promastigotes: partial purification and properties.Tropenmedizin und Parasitologie, 32 4
-
T. Booden, P. Boonlayangoor, R. Albach (1976)
Incorporation of purines and pyrimidines in axenically grown Entamoeba histolytica.The Journal of parasitology, 62 4
-
Richard Miller, D. Lindstead (1983)
Purine and pyrimidine metabolizing activities in Trichomonas vaginalis extracts.Molecular and biochemical parasitology, 7 1
-
Tulio Pizzi, W. Taliaferro (1960)
A comparative study of protein and nucleic acid synthesis in different species of trypanosomes.The Journal of infectious diseases, 107
-
M. Hamet, C. Bonissol, P. Cartier (1980)
Enzymatic activities on purine pyrimidine metabolism in nine mycoplasma species contaminating cell cultures.Clinica chimica acta; international journal of clinical chemistry, 103 1
-
K. Chang, R. Steiger, C. Dave, Y. Cheng (1978)
Effects of methylglyoxal bis(ganylhydrazone) on trypanosomatid flagellates: inhibition of growth and nucleoside incorporation in Trypanosoma brucei.The Journal of protozoology, 25 1
-
K. Yamada, I. Sherman (1981)
Purine metabolizing enzymes of Plasmodium lophurae and its host cell, the duckling (Anas domesticus) erythrocyte.Molecular and biochemical parasitology, 2 5-6
-
G. Kidder (1982)
Adenosine kinase from TrypanosomacruziBiochemical and Biophysical Research Communications, 107
-
J. Ávila, M. Polegre, R. Robins (1987)
Biological action of pyrazolopyrimidine derivatives against Trypanosoma cruzi. Studies in vitro and in vivo.Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 86 1
-
E. Koenigk (1978)
Purine nucleotide metabolism in promastigotes of Leishmania tropica: inhibitory effect on allopurinol and analogues of purine nucleosides.Tropenmedizin und Parasitologie, 29 4
-
Z. Etzion, R. Yagil (1987)
Metabolic effects in rats drinking increasing concentrations of sea-water.Comparative biochemistry and physiology. A, Comparative physiology, 86 1
-
W. Gutteridge, D. Dave, W. Richards (1979)
Conversion of dihydroorotate to orotate in parasitic protozoa.Biochimica et biophysica acta, 582 3
-
G. Schmidt, R. Walter, E. Koenigk (1974)
Adenosine kinase from normal mouse erythrocytes and from Plasmodium chabaudi: partial purification and characterization.Tropenmedizin und Parasitologie, 25 3
-
A. Gero, G. Coombs (1980)
Orotate phosphoribosyltransferase and orotidine‐5′‐phosphate decarboxylase in two parasitic kinetoplastid flagellatesFEBS Letters, 118
-
H. Webster, J. Whaun (1982)
Antimalarial properties of bredinin. Prediction based on identification of differences in human host-parasite purine metabolism.The Journal of clinical investigation, 70 2
-
J. O'daly, M. Rodríguez (1987)
Protein and nucleotide contamination of bovine liver catalase used in culture medium explains growth of Trypanosoma cruzi.Transactions of the Royal Society of Tropical Medicine and Hygiene, 81 1
-
H. Hassan, J. Mottram, G. Coombs (1985)
Subcellular localisation of purine-metabolising enzymes in Leishmania mexicana mexicana.Comparative biochemistry and physiology. B, Comparative biochemistry, 81 4
-
B. Hill, J. Kilsby, R. McIntosh, R. Wrigglesworth, C. Ginger (1981)
Pyrimidine biosynthesis in Plasmodium berghei.The International journal of biochemistry, 13 3
-
D. Iovannisci, David Goebel, Kelly Allen, K. Kaur, Buddy UllmanS (1984)
Genetic analysis of adenine metabolism in Leishmania donovani promastigotes. Evidence for diploidy at the adenine phosphoribosyltransferase locus.The Journal of biological chemistry, 259 23
-
J. Perrotto, D. Keister, A. Gelderman (1971)
Incorporation of precursors into Toxoplasma DNA.The Journal of protozoology, 18 3
-
K. Chalabi, W. Gutteridge (1977)
Presence and properties of thymidylate synthase in trypanosomatids.Biochimica et biophysica acta, 481 1
-
JoséLuis Avila, A. Avila, María Casanova (1981)
Differential metabolism of allopurinol and derivatives in Trypanosoma rangeli and T. cruzi culture forms.Molecular and biochemical parasitology, 4 5-6
-
T. Krenitsky, S. Neil, G. Elion, G. Hitchings (1969)
Adenine phosphoribosyltransferase from monkey liver. Specificity and properties.The Journal of biological chemistry, 244 17
-
J. Rasenack, J. Pausch, W. Gerok (1985)
De novo pyrimidine biosynthesis in isolated rat hepatocytes. Quantitative aspects of the regulation by UTP.The Journal of biological chemistry, 260 7
-
D. Iovannisci, K. Kaur, L. Young, B. Ullman (1984)
Genetic analysis of nucleoside transport in Leishmania donovaniMolecular and Cellular Biology, 4
-
W. Fish, J. Marr, R. Berens (1982)
Purine metabolism in Trypanosoma brucei gambiense.Biochimica et biophysica acta, 714 3
-
A. Irvin, E. Young (1977)
Possible in vitro test for screening drugs for activity against Babesia and other blood protozoaNature, 269
-
H. Dewes, H. Ostergaard, L. Simpson (1986)
Impaired drug uptake in methotrexate resistant Crithidia fasciculata without changes in dihydrofolate reductase activity or gene amplification.Molecular and biochemical parasitology, 19 2
-
L. Nolan, J. Berman, L. Giri (1984)
The effect of formycin B on mRNA translation and uptake of purine precursors in Leishmania mexicana.Biochemistry international, 9 2
-
D. Carson, K. Chang (1981)
Phosphorylation and anti-leishmanial activity of formycin B.Biochemical and biophysical research communications, 100 3
-
G. Kidder (1984)
Characteristics of cytidine aminohydrolase activity in Trypanosoma cruzi and Crithidia fasciculata.The Journal of protozoology, 31 2
-
D. James, G. Born (1980)
Uptake of purine bases and nucleosides in African trypanosomesParasitology, 81
-
B. Hansen, J. Perez-Arbelo, J. Walkony, L. Hendricks (1982)
The specificity of purine base and nucleoside uptake in promastigotes of Leishmania braziliensis panamensisParasitology, 85
-
P. Reyes, P. Rathod, Donald Sanchez, J. Mrema, K. Rieckmann, H. Heidrich, H. Heidrich (1982)
Enzymes of purine and pyrimidine metabolism from the human malaria parasite, Plasmodium falciparum.Molecular and biochemical parasitology, 5 5
-
D. Hart, K. Vickerman, G. Coombs (1981)
Transformation in vitro of Leishmania mexicana amastigotes to promastigotes: nutritional requirements and the effect of drugsParasitology, 83
-
S. Beverley, J. Coderre, D. Santi, R. Schimke (1984)
Unstable DNA amplifications in methotrexate resistant Leishmania consist of extrachromosomal circles which relocalize during stabilizationCell, 38
-
D. Hammond, W. Gutteridge (1980)
Enzymes of pyrimidine biosynthesis in Trypanosoma cruziFEBS Letters, 118
-
C. Wang, P. Simashkevich (1981)
Purine metabolism in the protozoan parasite Eimeria tenella.Proceedings of the National Academy of Sciences of the United States of America, 78 11
-
D. Hammond, J. Burchell, M. Pudney (1985)
Inhibition of pyrimidine biosynthesis de novo in Plasmodium falciparum by 2-(4-t-butylcyclohexyl)-3-hydroxy-1,4-naphthoquinone in vitro.Molecular and biochemical parasitology, 14 1
-
R. Krooth, K. Wuu, R. Ma (1969)
Dihydroorotic Acid Dehydrogenase: Introduction into Erythrocyte by the Malaria ParasiteScience, 164
-
J. Ryley, R. Wilson, M. Betts (1974)
Anticoccidial activity of an azauracil derivativeParasitology, 68
-
C. Garrett, J. Coderre, T. Meek, E. Garvey, D. Claman, S. Beverley, D. Santi (1984)
A bifunctional thymidylate synthetase-dihydrofolate reductase in protozoa.Molecular and biochemical parasitology, 11
-
N. Kobayashi, T. Matsuno, F. Hariguchi, T. Yamazaki, K. Imai, H. Onaga, T. Ishii (1986)
Eimeria tenella, E. necatrix, E. acervulina, E. maxima, and E. brunetti: potent anticoccidial activity of an uridine analog, 1-(beta-D-ribofuranosyl)-2(1H)-pyrazinone 4-oxide.Experimental parasitology, 61 1
-
G. Kidder, L. Nolan (1982)
Xanthine phosphoribosyltransferase in Leishmania: divalent cation activation.The Journal of protozoology, 29 3
-
H. Hassan, G. Coombs (1987)
Purine salvage by Acanthamoeba castellanii.International journal for parasitology, 17 7
-
R. Neal, S. Croft, D. Nelson (1985)
Anti-leishmanial effect of allopurinol ribonucleoside and the related compounds, allopurinol, thiopurinol, thiopurinol ribonucleoside, and of formycin B, sinefungin and the lepidine WR6026.Transactions of the Royal Society of Tropical Medicine and Hygiene, 79 1
-
Strauss Pr, Henderson Jf, Good Mg (1985)
Nucleosides and lymphocytes--an overview.Experimental Biology and Medicine, 179
-
G. Kidder, L. Nolan (1979)
Adenine aminohydrolase: occurrence and possible significance in trypanosomid flagellates.Proceedings of the National Academy of Sciences of the United States of America, 76 8
-
T. Spector, R. Miller (1976)
Mammalian adenylosuccinate synthetase. Nucleotide monophosphate substrates and inhibitors.Biochimica et biophysica acta, 445 2
-
W. Gutteridge, M. Davies (1981)
Enzymes of purine salvage in Trypanosoma cruziFEBS Letters, 127
-
R. Albach, J. Shaffer, R. Watson (1966)
Autoradiographic studies of H3-thymidine uptake in Entamoeba histolytica in CLG medium.The Journal of protozoology, 13 2
- Publisher
- Oxford University Press
- Copyright
- © 1988 Federation of European Microbiological Societies
- ISSN
- 0168-6445
- eISSN
- 1574-6976
- DOI
- 10.1111/j.1574-6968.1988.tb02708.x-i1
- pmid
- 3078769
- Publisher site
- See Article on Publisher Site
Abstract
FEMS Microbiology Reviews 54 (1988) 47-84 47 Published by Elsevier FER 00085 Husain F. Hassan * and Graham H. Coombs University of Glasgow, Department of Zoology, Glasgow, U.K. Received 2 April 1987 Accepted 16 July 1987 Key words: Purine; Pyrimidine; Parasite; Chemotherapy now less useful, due to the advent of drug-re- 1. INTRODUCTION sistant strains of the parasites. There is a pressing Many parasitic protozoa are major causes of need for new antiprotozoal drugs. suffering and economic loss in the world today. Several of the currently available antimicrobial Malaria kills more than a million people every drugs act by interference with some component of year, whereas the trypanosomiases and the leish- the purine and pyrimidine metabolism of the target maniases are also great problems in the tropics organism. This has stimulated the extensive stud- and sub-tropics. Amoebiasis, giardiasis and tri- ies that have been carried out over many years on this area of metabolism in parasitic protozoa. It chomoniasis cause widespread suffering, the latter was hoped that these studies would provide the two being endemic in most countries of the world, baseline data required for the design and develop- and it is at last being widely accepted that toxop-
Journal
FEMS Microbiology Reviews – Oxford University Press
Published: Feb 1, 1988