Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Prospective study of the forearm bone mineral density of long-term users of the levonorgestrel-releasing intrauterine system

Prospective study of the forearm bone mineral density of long-term users of the... BACKGROUNDThe levonorgestrel-releasing intrauterine system (LNG-IUS) induces amenorrhoea, and its effect on bone mineral density (BMD) may constitute a concern. This study evaluated BMD in long-term users of the LNG-IUS or intrauterine device (IUD).METHODSBMD was evaluated at the midshaft of the ulna and ultra-distal radius using dual-energy X-ray absorptiometry in 37 women at 7 or 10 years of use following placement of a second LNG-IUS. The groups were paired for duration of use, age, body mass index (BMI), ethnicity and number of pregnancies.RESULTSThe mean age of both LNG-IUS and IUD users at the 7th and 10th year was 34 and 38 years, respectively. Mean BMI was 25 in both groups, increasing to 26 at the 10th year. Amenorrhoea occurred in 51.4 and 91.9 of LNG-IUS users at the 7th and 10th year, respectively. Estradiol levels in LNG-IUS users were normal at both evaluations. There were no differences in BMD (g/cm2) at the midshaft of the ulna nor ultra-distal radius between LNG-IUS and IUD users or between the 7th and 10th years of use in LNG-IUS users. A Z-score below 2SD at the ultra-distal radius was observed in only one LNG-IUS user and in none of the IUD users at the 10th year. Higher BMI and BMD at the seventh year and amenorrhoea were predictors of higher BMD at the 10th year.CONCLUSIONSBMD at the midshaft of the ulna and ultra-distal radius in LNG-IUS users were similar to that of IUD users and remained unchanged between the 7th and the 10th years of use. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Human Reproduction Oxford University Press

Prospective study of the forearm bone mineral density of long-term users of the levonorgestrel-releasing intrauterine system

Download PDF
7 pages

Loading next page...
 
/lp/oxford-university-press/prospective-study-of-the-forearm-bone-mineral-density-of-long-term-XjwiPLFh6k

References (37)

Publisher
Oxford University Press
Copyright
The Author 2010. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissionsoxfordjournals.org
Subject
ORIGINAL ARTICLES
ISSN
0268-1161
eISSN
1460-2350
DOI
10.1093/humrep/deq043
pmid
20185512
Publisher site
See Article on Publisher Site

Abstract

BACKGROUNDThe levonorgestrel-releasing intrauterine system (LNG-IUS) induces amenorrhoea, and its effect on bone mineral density (BMD) may constitute a concern. This study evaluated BMD in long-term users of the LNG-IUS or intrauterine device (IUD).METHODSBMD was evaluated at the midshaft of the ulna and ultra-distal radius using dual-energy X-ray absorptiometry in 37 women at 7 or 10 years of use following placement of a second LNG-IUS. The groups were paired for duration of use, age, body mass index (BMI), ethnicity and number of pregnancies.RESULTSThe mean age of both LNG-IUS and IUD users at the 7th and 10th year was 34 and 38 years, respectively. Mean BMI was 25 in both groups, increasing to 26 at the 10th year. Amenorrhoea occurred in 51.4 and 91.9 of LNG-IUS users at the 7th and 10th year, respectively. Estradiol levels in LNG-IUS users were normal at both evaluations. There were no differences in BMD (g/cm2) at the midshaft of the ulna nor ultra-distal radius between LNG-IUS and IUD users or between the 7th and 10th years of use in LNG-IUS users. A Z-score below 2SD at the ultra-distal radius was observed in only one LNG-IUS user and in none of the IUD users at the 10th year. Higher BMI and BMD at the seventh year and amenorrhoea were predictors of higher BMD at the 10th year.CONCLUSIONSBMD at the midshaft of the ulna and ultra-distal radius in LNG-IUS users were similar to that of IUD users and remained unchanged between the 7th and the 10th years of use.

Journal

Human Reproduction – Oxford University Press

Published: May 25, 2010

Keywords: bone mineral density levonorgestrel-releasing intrauterine system Mirena contraception

There are no references for this article.