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G. Vicidomini, M. Santini, A. Fiorello, V. Parascandolo, B. Calabrò, V. Pastore (2005)
Intraoperative pleural lavage: is it a valid prognostic factor in lung cancer?The Annals of thoracic surgery, 79 1
K. Kodama, O. Doi, M. Higashiyama, H. Yokouchi, M. Tatsuta (1993)
Long‐term results of postoperative intrathoracic chemo‐thermotherapy for lung cancer with pleural disseminationCancer, 72
F. Schmidt (2008)
Meta-AnalysisOrganizational Research Methods, 11
E. Lim, Ayyaz Ali, P. Theodorou, A. Nicholson, G. Ladas, P. Goldstraw (2004)
Intraoperative pleural lavage cytology is an independent prognostic indicator for staging non-small cell lung cancer.The Journal of thoracic and cardiovascular surgery, 127 4
M. Higashiyama, O. Doi, K. Kodama, H. Yokouchi, R. Tateishi, T. Horai, Jun-ichi Ashimura, S. Nagumo, Yasuyoshi Naruse (1997)
Pleural lavage cytology immediately after thoracotomy and before closure of the thoracic cavity for lung cancer without pleural effusion and dissemination: Clinicopathologic and prognostic analysisAnnals of Surgical Oncology, 4
K. Kodama, O. Doi, M. Tatsuta, K. Kuriyama, R. Tateishi (1989)
Development of postoperative intrathoracic chemo‐thermotherapy for lung cancer with objective of improving local cureCancer, 64
T. Nakagawa, N. Okumura, Yujiro Kokado, K. Miyoshi, Tomoaki Matsuoka, Kotaro Kameyama (2007)
Clinical relevance of intraoperative pleural lavage cytology in non-small cell lung cancer.The Annals of thoracic surgery, 83 1
(1997)
Revision in the international system for staging lung cancer
Y. Satoh, Rira Hoshi, Y. Ishikawa, T. Horai, S. Okumura, K. Nakagawa (2007)
Recurrence patterns in patients with early stage non-small cell lung cancers undergoing positive pleural lavage cytology.The Annals of thoracic surgery, 83 1
Y. Kawakami, S. Ogura (2000)
[The outline of the general rule for clinical and pathological record of lung cancer].Nihon rinsho. Japanese journal of clinical medicine, 58 5
M. Okada, T. Sakamoto, W. Nishio, K. Uchino, K. Tsuboshima, N. Tsubota (2003)
Pleural lavage cytology in non-small cell lung cancer: lessons from 1000 consecutive resections.The Journal of thoracic and cardiovascular surgery, 126 6
M. Muraoka, T. Oka, S. Akamine, T. Tagawa, M. Morinaga, M. Inoue, T. Yamayoshi, S. Hashizume, Keitaro Matsumoto, Tomayoshi Hayashi, T. Nagayasu (2006)
Modified intrapleural cisplatin treatment for lung cancer with positive pleural lavage cytology or malignant effusionJournal of Surgical Oncology, 93
C. Dresler, C. Fratelli, J. Babb (1999)
Prognostic value of positive pleural lavage in patients with lung cancer resection.The Annals of thoracic surgery, 67 5
S. Enatsu, J. Yoshida, T. Yokose, M. Nishimura, Y. Nishiwaki, T. Shirakusa, K. Nagai (2006)
Pleural lavage cytology before and after lung resection in non-small cell lung cancer patients.The Annals of thoracic surgery, 81 1
M. Higashiyama, K. Kodama, H. Yokouchi, K. Takami, T. Nakayama, T. Horai (2000)
Clinical value of pleural lavage cytological positivity in lung cancer patients without intraoperative malignant pleuritis. Recurrent pattern based on semiquantitative analysis of tumor cells in pleural lavage.The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi, 48 10
Y-N Li, H-Z. Shi, Q. Liang, H-B Yang, G-M Huang (2008)
Prognostic significance of pleural lavage cytology in patients with lung cancer: a meta-analysis.Lung cancer, 60 2
Y. Ichinose, R. Tsuchiya, T. Koike, T. Yasumitsu, Kenji Nakamura, H. Tada, H. Yoshimura, T. Mitsudomi, K. Nakagawa, K. Yokoi, H. Kato (2002)
A prematurely terminated phase III trial of intraoperative intrapleural hypotonic cisplatin treatment in patients with resected non-small cell lung cancer with positive pleural lavage cytology: the incidence of carcinomatous pleuritis after surgical intervention.The Journal of thoracic and cardiovascular surgery, 123 4
Purpose: The clinical significance of intraoperative pleural lavage cytology (PLC) for lung cancer has been insufficiently elucidated. We therefore reviewed the surgical results of lung cancer patients without carcinomatous pleuritis followed up over the long term to elucidate PLC implications. Patients and methods: PLC was performed immediately after thoracotomy in consecutive lung cancer patients without carcinomatous pleuritis undergoing tumor resection between 1988 and 1997. Postoperative follow-up was generally performed for at least 5 years while checking tumor recurrence and survival. Results: Eighty-nine (13.1%) of 679 patients had positive PLC findings, which were observed more frequently in patients with advanced stage, larger tumor size, higher involvement of the pleura, lymph node, lymphatics and vessels. The overall 5- and 10-year survival rates in PLC-positive patients were 43% and 25%, respectively, while those in PLC-negative patients were 66% and 58%, respectively (p ≪ 0.0001). Among 395 patients with stage I disease, 35 (8.9%) showed PLC-positive findings, and their overall survival rate was significantly poor compared with those with PLC-negative findings (p ≪ 0.0001). In contrast, such differences were not observed among patients with more advanced stage diseases. In regard to histological type, a difference in the postoperative survival rate according to PLC status was statistically found in adenocarcinoma type (p ≪ 0.0001), but not in squamous cell carcinoma type (p = 0.24). According to multivariate analysis, PLC was an independent prognostic factor for all tested patients (p = 0.007, hazard ratio = 0.60) as well as for those with stage I disease (p = 0.0135, hazard ratio = 0.51). When examining postoperative pleural recurrence, the rate for PLC-positive patients was statistically higher than that for PLC-negative patients (p ≪ 0.0001, hazard ratio = 0.08). Interestingly, late pleural recurrence more than 5 years occurred in five (5.6%) of PLC-positive patients, all of whom were included in stage I. Conclusions: Based on the present analysis of long-term follow-up after operation, PLC may also be an independent prognostic factor. In particular, the PLC status of patients with stage I disease or adenocarcinoma type has an important impact on survival. PLC-positive findings may be a high risk for postoperative pleural recurrence. For PLC-positive patients with stage I disease, careful serial follow-up for more than 5 years is required while paying attention to late pleural recurrence.
European Journal of Cardio-Thoracic Surgery – Oxford University Press
Published: Feb 1, 2009
Keywords: Keywords Lung cancer Pleural lavage cytology (PLC) Prognosis Pleural recurrence
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